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21 Cards in this Set

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Adult Connective Tissues

1) Loose CT


2) Dense CT


3) Reticular CT


4) Elastic CT

Special Connective Tissues

1) adipose tissue


2) cartilage


3) bone


4) bone marrow

Fibers

1) collagen fiber


2) elastic fiber


3) reticular fiber

collagen

1) glycine, hydroxyproline, hydroxylysine


2) triple helix

collagen type I-IV

Type I: connective tissue, bone, dentin


Type 2: cartilage


Type 3: reticular fibers


Type 4: lamina densa of basal lamina

reticular fibers

type III collagen


doesn't stain well with H&E --> PAS or silver


hematopoietic organs (spleen, lymph nodes, marrow and liver)

elastic fibers

- core of elastin and surrounding fibrillin

elastin

1) rich in proline and glycine


2) unique amino acids: desmosine and isodesmosine

ground substances

1) glycosaminoglycans (GAGs)


2) proteoglycans


3) glycoproteins

GAGs

- one of the two sugar - amino sugar


- highly negatively charged due to sulfate and carboxyl groups


- highly negative charges attract water-forming hydrated gel

Proteoglycans

- consists of a core protein link tetrasacchride


- GAG

Fibronectin

- glycoproteins


- dimer: two large subunits connected by disulfide bonds

Laminin

- major components of basement membrane


- binds integrin, heparin sulfate and type IV collagen

Mast cells

- Binds to IgE --> release of granules


- histamine: increase permeability of post capillary venules


- ECF-A: attractant eosinophils


- Heparin: anticoagulant

Macrophages

- derived from monocytes


- examples: Kupffer cells, Langerhands, Osteoclasts, Microglia

leptin

- produced by adipose tissue


- primary target: hypothalmus


- activity: reduce appetite, increase BMR


- leptin resistance --> obesity

Hemacrit

- percentage of whole blood that is packed in red blood cells


- male: 46% (because of androgen)


- female: 42%

Platelets

- derived from megakaryocytes


- normal lifespan: 10 days


- no nucleus


- production stimulated by thrombopoietin

Types of Leukocytes

1) Neutrophils (40-75%)


2) Lymphocytes (20-50%) - agranulocyte


3) Monocyte (2-10%) - agranulocyte


4) Eosinophils (1-6%)


5) Basophils (<1%)




Never Let Monkey Eat Bananas

Basophil

- similar to mast cells


- binds to IgE --> stimulate degranulation


- specific granules contain histamine, heprain sulfate, hyaluronate, serotonin


- not phagocytic