Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
Describe the mesangial cells
|
derived from smooth muscle cells
produce mesangial matrix "intercapillary cells" possess contractile and phagocytic properties can proliferate |
|
|
Describe the endothelial cells of the glomerulus
|
Lines the capillaries themselves
|
|
|
Describe the epithelial cell of the glomerulus
|
AKA Podocyte, lies within Bowman's space, cover the capillaries
|
|
|
What can happen with podocyte foot process effacement?
|
Lipoid nephrosis; responds to steroids
|
|
|
What can happen with podocyte hypertrophy?
|
Focal segment glomerular sclerosis; edema all over body; do not respond to steroids long term
|
|
|
What can happen with podocyte crescents?
|
Wegener's granulomatosis
|
|
|
What nephron feature is associated with diabetes mellitus?
|
Thick basement membrane, Increased matrix
|
|
|
What glomerular feature is associated with Alport's syndrome?
|
Thin basement membrane
|
|
|
What nephron feature is associated with arterial narrowing?
|
Wrinkled/collapsed basement membrane/capillary wall
|
|
|
What basement membrane patter is associated with membranous nephropathy?
|
Subepithelial deposits
|
|
|
What pattern of injury is associated with Lupus nephritis?
|
Subendothelial deposits
|
|
|
What pattern of injury is associated with Lupus nephritis?
|
Subendothelial deposits
|
|
|
What mesangial cell pattern is associated with Post infectious GN?
|
Increased mesangial cells
|
|
|
What pattern of injury is associated with Berger's disease (IgAN)?
|
Increased mesangial matrix and cells
|
|
|
What pattern of injury is associated with mesangiocapillary GN?
|
Interposition of mesangial cells
|
|
|
What are the LM features of the proximal convoluted tubule?
|
Location: cortex, most numerous tubule segment
Cytoplasm: eosinophilic, granular (numerous mitochondria) Lumenal Surface: brush (microvilli) border, PAS positive Nucleus: central or near base Lateral cell borders: indistinct (cell borders interdigitate) Lumen: small |
|
|
What EM features are present in the thick ascending limb of the distal tubule - thick ascending limb?
|
Microvilli sparse, basal infolding of plasma membrane deep, extensive and associated with high enzyme content; mitochondria long rod shaped, intimate relationship with basal infolding, apical vesicles
|
|
|
What is the function of the thick ascending limb of the distal tubule?
|
Energy dependent transport: K+, Na+, Cl-
Impervious to water (ountercurrent multiplier) Produce Tamm Horsfall protein (function?) |
