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39 Cards in this Set
- Front
- Back
thyroid fucntion
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hypothyroid
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ab in graves
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anti-TSHr
anti-TPO anti-TG |
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HLA type in graves
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HLA-DR3
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lymphs involved in graves
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Th
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thyroid function
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graves, hyperthyroid
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abs
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antiTG and antimicrosomal abs (hashimoto's)
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hla types a/w hashimoto's
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HLA B8, DR 5
(T cell defect...) |
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what is it, thyroid
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antimicrosomal antibodies in hashimoto's
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two syndromes a/w hashimoto's thyroiditis
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Turners
downs |
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hurthle cells on em
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mitochondria filled
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malignant a/w hashimoto's
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lymphoma
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what sx
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prior URI, fever, dequervain's
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IgG4 dz of thyroid
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riedel's thyroid
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hx of rock hard, hard to get out thyroid per surgeon
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riedel's
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helpful diagnostic clue for amyloid goiter
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fat metaplasia
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association?
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minocycline use
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where do you find this
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sclerosing variant of mucoepidermoid
thyroid, lung, salivary gland note: lots of eos, fibrosis |
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options for bethesda system in thyroid
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Nondiagnostic or
Unsatisfactory Benign Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (FLUS) Follicular Neo. or Suspicious for a Follicular Neoplasm Suspicious for Malignancy Malignant |
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nice helpful fx for HTA of thyroid micro
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Metachromatic basement membrane-like material
between cells |
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cytoplasmic inclusions in HTA - what's in them
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representing giant lysosomes
2-5 micron, yellow, spherical, cytoplasmic bodies with clear halo of retracted cytoplasm and nuclear molding |
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most common malignant neo of thyroid
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papillary
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does papillary thyroid ca met to LN
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yes
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ihc for papillary ca
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CK 19 +, HBME +, TG and TTF 1+
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molecular changes in pap ca of thyroid
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Ret PTC 1
Ret PTC 3 (related to XRT) APC, PTEN (think cowden's, Fap??) RAS mutation (relates to follicular variant) NTRK 1 |
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what are two specific fx about follicular variant of pap
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- ras mutations more common
- more often vascular invasion |
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aggressive variants of PTC (4), which is worst
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tall cell
hurthle cell sclerosing (psammomas) columnar (very aggresiive) PTC that reaks Havoc (Psammomas, Tall, Columnar, Hurthle) |
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in whom do you see sclerosing variant PTC
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young, psammomas, fibrosis
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in whom do you see tall cell, mutation
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older, BRAF
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what does columnar cell variant of PTC look like
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proliferative endometrium, more aggressive, may see sq morules
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Familial PTC: clinical fx
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associated with familial
adenomatous polyposis (+/- Gardner’s syndrome), young females, cribriform and squamous metaplastic appearance |
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what tumor is a/w iodine deficiency
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follicular ca
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how does follicular ca spread
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hematogenously
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mutations seen in follicular ca
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RAS mutation
t(2:3)(q13:p25), PAX 8-PPAR gamma 1 fusion gene |
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how aggressive
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more aggressive than differentiated, less bad than anaplastic
can see necrosis (uncommon in thyroid tumor as a whole) |
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serum findings
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medullary: plasmacytoid and spindled cells
sipples (MEN IIA and B) CT increase |
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what other tumors
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IIb: submucosal neuroma; gangioneuromas, marfanoid
+IIa (medullary thyroid, pheo) (also parathyroid adenomas and pit hyperplasia) |
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bull's neck ,thyroid, mutaiton
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anaplastic
p53 elderly females |
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of thyroid which tumors to blood
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follicular, anaplastic
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of thyroid which tumors to LN
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papillary, medullary
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