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58 Cards in this Set
- Front
- Back
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ihc for myoepithelial cells
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Alpha smooth muscle actin +
Calponin + Caldesmon + S-100 + HMW CK + Smooth muscle myosin heavy chain + Rare GFAP + Negative for ER, PR, desmin, LMW CK |
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what is polythelia
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supernumery nipples
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what is polymastia
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extra breast tissue (usu axillary)
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acute mastitis often associated with what bug
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S aureus
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hx fx of duct ectasia
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Dilated ducts
inspissated secretions Plasma cell mastitis |
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asteroid bodies in breast
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silicon implants (also sarcoid)
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increase cancer risk from "b9" breast lesions
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x 4-5 risk (not sure of first and last in terms of numerics!)
Florid epithelial hyperplasia atypical lobular hyperplasia Atypical ductal hyperplasia Family history |
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if see myxoid FA, think
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Carney’s syndrome (cardiac and
cutaneous myxomas, myxoid FA, endocrine overactivity, pigmentation) |
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how phyllodes tumor is spread
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hematogenously**
recall: can see heterologous elements in phyllodes tumors |
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what
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lactating adenoma!!!- note dilated glands
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most common malignancies in pregnant women
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1. cervical
2. breast |
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what
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tubular adenoma
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what, need to excise?
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adenomyoepithelioma
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are large duct intraductal papillomas premalignant?
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no, >50 years
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what
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nipple adenoma
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paget's dz of breast - ul or bl
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unilateral
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ihc for paget's dz of breast
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Mucin, PAS, BRST-2, ER, CK 7, EMA+
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ddx of paget's dz
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D/D: Bowen’s disease, melanoma, clear cell
change in epidermis |
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any increased risk for breast ca; sclerosing adenosis
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1.7x
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what
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microglandular adenosis; mimic of ca; PAS-D + hyaline eosinophilic material
NO MYOEPITHELIAL CELLS so don't be fooled |
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what is secretory adenosis
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same thing as microglandular adenosis but two layers
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increased risk of radial scar
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1.8x
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CK5/6+ in UDH of breast
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positive, goes away in ADH
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cytogenetic findings in ADH and DCIS
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16q-, 17p-, 1q+
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definition of microinvasive ca
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Less than or equal to 1mm in any single focus
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cytogenetics and ihc of lobular ca
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ER +PR +HER-2/neu –E-Cadherin – (DCIS is +)
16q-, 1q+ (similar to dcis except that listed included 17p) |
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LCIS risks for breast ca
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Subsequent invasive cancer in either breast 25%
patients: lobular or ductal; ~10x risk |
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what
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breast - intracytoplasmic mucin droplet
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where does lobular ca met to
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Metastases: CSF, ovaries, uterus, peritoneal
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ihc for lobular ca
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ER, PR + HER-2/neu -
S100, cyclin D1, GCDFP 15 + E-cadherin – (note: positive in tubulolobular variant) |
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most aggressive breast cas
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Ductal
Lobular Squamous Metaplastic Apocrine |
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what, ihc, histochemical stain
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apocrine cell ca
androgen+, er/pr- PASDr |
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low grade invasive ca of breast
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Papillary (older patients)
Tubular (best prognosis, apical snouts) Colloid Medullary Adenoid Cystic Juvenile (aka secretory ca) |
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what
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medullary ca (recall may be better prognosis but triple negative tumor!!!)
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what type of breast ca is increased in brca1 (at least this one)
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medullary
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another name for secretory ca
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juvenile ca
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what, patient population, histology, histochemical staining
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secretory ca
Juvenile carcinoma (children, adults) Well-circumscribed, pushing margins Central hyalinization Cells with vacuolated cytoplasm Eosinophilic PAS+ secretion |
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what, prognostically, ihc
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micropapillary ca
likely to have LN mets ihc: funny staining pattern muc1 and ema - reverse polarity |
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prognosis
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metaplastic ca, worse prognosis
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what
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granular cell tumor
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what
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angiosarcoma
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ihc staining
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PASH
Positive stains: vimentin, CD34, PR (intense) Negative stains: Factor 8, Ulex, CD31, ER, keratin |
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what
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gynecomastia
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what
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met prostate ca (loves to go to breast)
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treatment for her2/neu
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herceptin/adriamycin (better response to anthracyclines if her2/neu positive)
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review cold ischemia time/formalin fixation time
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review
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genetic predisposition to breast ca/syndrome
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BBLCA
Brca1 and 2 Li fraumeni cowden's ataxia-telangiectasia |
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czomal site: BRCA 1
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17q21
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czomal site: brca2
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13q12
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mutation: li fraumeni
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p53
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czomal site: cowden
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10q
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Ataxia telangiectasia czomal site
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czome 11
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what are brca1 patients at risk for
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Medullary, HG tumors
Ovary, prostate, colon |
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luminal A pattern
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ER, PR+; Her2 -
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luminal B pattern
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ER, PR+; Her2+/-
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her2 type breast ca
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ER, PR -; Her2 +
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basal type: pattern, who gets it
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triple neg, young AA
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what are brca2 at risk for
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breast ca
Male breast, ovary, prostate, pancreas breast and POP (in male breast ca) |
