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37 Cards in this Set
- Front
- Back
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What is seroprevalence of HSV?
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70% for 1; 25-30% for 2
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How is HSV-1 tmitted?
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saliva
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What are 4 characteristics of HSV-1?
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DNA virus, replicates in nucleus, enveloped, latent in ganglia
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What are the 3 phases of HSV-1 pathogenesis?
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est - replication at peripheral site, inf resolved; maintenance - virus goes to sensory ganglia, acute inf; reactivation
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What are primary manifestations of HSV-1 inf?
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child - gingivostomatitis, fever, lesions; adult - severe pharyngitis; or can be asymptomatic
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What are 2ary manifestations of HSV-1?
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cold sore recurring w/ stress, UV light, inf, menses, dec immunity
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What are manifestations of HSV-1 in immune competent?
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genital herpes, encephalitis, keratitis
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What are manifestations of HSV-1 in immune suppressed?
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pneumonia, severe mucocutaneous lesions
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What is tx of HSV-1?
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acyclovir
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What are 2 PW of pathogenesis of HSV-2?
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inf -> asymptomatic shedding -> latent in ganglia; or genital lesions -> latent in ganglia -> genital lesions or asym shedding
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What are clinical manifestations of genital HSV?
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urethral/vaginal d/c, fever, meningitis, genital lesions/pain, immune suppressed - mucocutaneous lesions
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What is tx of genital HSV?
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acyclovir
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What is epidemiology of varicella-zoster?
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97% adults sero+
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What is pathogenesis of VZV?
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enters resp tract and replicates, varicella shed from resp, replication in LN, viremia, virus infects skin, latency in ganglia - immune compromised get decline in VZV T cells -> varicella
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What is clinical manifestation of varicella?
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erythematous maculopapular rash
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What is clinical manifestation of zoster (shingles)?
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rash along dermatome, post herpetic neuralgia
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How is VZV diagnosed?
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simultaneous presence of maculopapular lesion, vesicular lesions, scabs
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How is varicella tx?
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symptomatic, severe cases use acyclovir
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How is zoster tx?
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acyclovir for rash, low dose tricyclic antibiotics for pain
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How is shingles prevented?
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Zostavax is people 60+
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What is epidemiology and tmsission of EBV?
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85% seroprevalence among adults, tmitted by saliva
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What is pathogenesis of EBV?
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DNA virus, enters oropharynx, replicates in epi cell nucleus, infects B cells - latent in memory B cells, shed in saliva 3-18 mos after inf
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What herpes virus is implicated in certain cx?
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EBV
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What are clinical manifestations of EBV?
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in children to young adult - infectious mono - wks or longer, fever, exudative pharyngitis, profound fatigue, hepatosplenomegaly, cervical lymphadenopathy, oral hairy leukoplakia
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How is EBV diagnosed?
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heterophi Ab test - EBV stimulates heterophil Ab that agglutinate sheep bld; CBC and diff (lymphocytosis 10% atypical lymphs)
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What are non-EBV causes of mono symptoms?
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CMV, toxoplasmosis, HIV
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What cx are assoc w/ EBV?
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Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkins' lymphoma, T cell malignancy
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What is epi of CMV?
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70% seroprevalence among adults
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What are routes of tmission of CMV?
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during neonatal period - in utero, breast milk; puberty onward - bld, saliva, urine, sexual contact
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Where does CMV become latent?
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WBCs
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What are congenital manifestations of CMV?
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10% are symptomatic at birth - low BW, perichiae, hepatosplenomegaly, microcephaly, deafness, jaundice; late onset symptoms of deafness
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What are clinical manifestations of CMV in immune suppressed?
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pneumonia, retinitis, GI dx,encephalitis
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What are symptoms of CMV in immune competent?
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asymptomatic shedding, tplacental tmission, mono-like
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How is CMV diagnosed?
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virus isolation from tissue/body fluid, CMV Ag detection, PCR
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How is CMV tx?
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ganciclovir
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What is symptom of HSV 6 & 7?
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exanthem subetim (roseola infantum), very common inf
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What HSV is assoc w/ Kaposi's sarcoma?
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HSV 8
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