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7 Cards in this Set
- Front
- Back
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primary phases of hemostasis =vascular and platelet aggregation |
local response to vascular injury form platelet plug adhering to endothelial wall limit bleeding immediately |
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secondary hemostasis =clotting cascade |
result in form stable clot involve enzymatic activation of coagulation proteins that function to produce fibrin as reinforcement of platelet plug gradually stable plug will be dissolved by fibrinolysis |
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injury to enthothelial cells promotes |
localized clot formation vasoconstriction via thromboxane a2(txa2)=narrow lumen of vessel to minimize blood loss bring hemostatic component of blood (platelet and plasma protein) into closer proximity to vessel wall enhance contact activation of platelets activated platelets enhance coagulation proteins |
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platelet is |
anucleated (no nucleus) cytoplasmic fragments, released from megakaryocytes in bone marrow |
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platelet aggregation |
activated platelet aggregate process regulated in part by prostaglandin |
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vessel injury |
calcium and vitamin-k dependent platelets(-) adhere to exposed collagen(+) on vessel wall |
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prostacyclin |
inhibit platelet aggregation in healthy vessels |
