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22 Cards in this Set
- Front
- Back
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CML
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t(9;22) = Philadelphia chromosome
bcl-abl hybrid |
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Burkitts Lymphoma
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t(8;14)
c-myc activation |
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Follicular Lymphomas
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t(14;18)
bcl-2 activation |
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M3 type of AML
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t(15;17)
All responsive to all trans-retinoic acid |
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Ewings Sarcoma
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t(11;22)
*Patrick Ewings # 11+22 = 33 |
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Mantle Cell lymphoma
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t(11;14)
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Protooncogenes
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**all lowercase except TGF
ras n-myc erb-B1 Erb-B2 TGFalpha sis abl |
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Tumor Suppressor Genes
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**All capitalized except p53
BRCA1/2 NF1 APC/beta-catenin DCC p53 RB WT-1 |
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Ras
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Cancers of bladder, lung, colon, pancreas, kidney
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n-myc
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neuroblastoma
Small cell carcinoma of lung |
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erb-b1
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squamous cell carcinoma of lung
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erb-b2
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breast and ovarian cancer
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TGF alpha
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astrocytoma
hepatocellular carcinoma |
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sis
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astrocytoma
osteosarcoma |
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abl
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CML
ALL |
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BRCA1/2
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Breast and ovarian cancer
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NF1
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neuroblastomas
neurofibromatosis 1 sarcomas |
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APC/beta-catenin
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gastric, colon and pancreatic cancers
Familial Adematous Polyposis Coli |
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DCC
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colon cancer
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p53
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majority of cancers
Li-Fraumeni Syndrome |
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RB
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retinoblastoma
osteosarcoma others |
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WT-1
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Wilms tumor
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