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21 Cards in this Set

  • Front
  • Back
CD 10, 19, 20, TdT+, sIg-

t(12;21), t(9;22)


Vincristine, prednisone, daunorubicin, asparaginase
CD1,2, cytCD3, TdT+

Adolescent males
CD5, 23, 19, 20

Del 11, 13, and tri 12


Chlorambucil, fludarabine, cyclophosphamide, rituximab
CD 10, 19, 20, BCL6 (blocks differentiation).

t(14;18)-DLBCL a progression from follicular lymphoma
EBV assoc w/ immunodef.

All ages, 60+ common

Tx: same as CLL, anti-CD20 aby
Follicular lymphoma
CD 10, 19, 20, sIg, BCL6 and BCL2

t(14;18): BCL6-IgH


Same as CLL
Burkitt's Lymphoma
CD 10, 19, 20, sIg, BCL6. NO BCL2

t(8;14): c-MYC-IgH

Kids and young adults
Mantle cell
CD 5, 19, 20, sIg (23 negative)

t(11;14): cyclin D1-IgH

Older males

Poor px
Marginal zone
CD 10, 19, 20

Assoc w/ inflammation

Tx by removing enciting agent (H. pylori)
Hairy Cell
CD 19, 20, 25, 103, 11c

TRAP: tartrate resistant acid phosphatase

Middle age white males. Splenomegaly, hypercellular BM, pancytopenia.

Tx: gentle chemo, cladipine, pentostatin
Multiple myeloma
Plasma cell markers. Bence-Jones protein, M protein, punched out lesions, amyloidosis.

t(11;14)-Cyclin D1-IgH
t(4;14)-FGFR3-signals w/ cyclin D1
del 11q13-poor px

IL-6->MIP1-alpha->NF-kB->RANKL->incr osteoclast activity

Older adults, African descent

DVd, thalidomide
Waldenstrom macroglobulinemia
CD20, sIg, high levels monoclonal IgM. Heavy chains=light chains

Del at 6q

Older adults

Incurable, anti-CD20 aby, palliative plasmaphoresis
Adult T cell Leukemia/Lymphoma
CD4+, cloverleaf nuclei

HTLV encodes TAX protein that activates NF-kB

Japan, W. Africa, Caribbean

Poor px, aggressive chemo
Mycosis fungoides
CD4+, CLA, CCR4, CCR10, Sezary cells

Older pts, indolent at first. Progresses to Sezary dz (involves blood, BM, and skin)

Poor px
Nodular sclerosis (HL)
Most common HL, classical, CD 15, 30, PAX5, EBV NEGATIVE.

30's, M=F

MOPP, ABVD, or combo
Mixed cellularity (HL)
Classical. CD 15, 30, EBV+

Young OR old adult MALES

MOPP, ABVD, or combo
Lymphocyte Rich (HL)
Classical. CD 15, 30, EBV+


MOPP, ABVD, or combo tx
Lymphocyte Depleted (HL)
CD 15, 30, and EBV+


MOPP, ABVD, or combo tx
Lymphocyte Predominant (HL)
Non-classical. EBV negative, CD 20, BCL6 (NO CD 15, 30). Popcorn cells.


MOPP, ABVD, or combo tx
CD 33, 34

t(8;21) + inv(16)->CBF1alpha/CBF1beta fusion protein, blocks differ. Favorable px

Inv(16)-MYH11, abnormal precursors block differ. Favorable

t(15;17): RARalpha-PML. Intermediate px, tx w/ ATRA

t(11q23; var)-histone/chromatin modifier. Iatrogenic, dismal px
CD34, low leuk alk phos

t(9;22): BCR-ABL fusion, constitutively active tyr-kinase

Adults in 50's. 3 stages: chronic, acclerated, blast crisis. Insidious onset, serendipitous dx.

Tx w/ imatinib in combo w/ hydroxyurea, kids get BMT
Clonal stem cell that may develop into AML. Ineffective hematopoiesis.

May be idiopathic or secondary to tx (t-MDS).

Dz of elderly (70's), hypercellular, dysplastic BM w/ ringed sideroblasts, megaloblastoid mutations, Pseudo-Pelger Huet cells.

BMT for younger pts