Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
61 Cards in this Set
- Front
- Back
|
RBC count in males (normal)
|
4.3-5.9 x 10^6/mm^3
(increased/normal in thalassemia) (decreased in iron deficiency) (both microcytic - good way to distinguish) |
|
|
RBC count in females (normal)
|
3.5-5.0 x 10^6/mm^3
|
|
|
HGB in males (normal)
|
13.6-17.2 gm/dl
|
|
|
HGB in females (normal)
|
12.0-15.0 gm/dl
|
|
|
HCT in males (normal)
|
39-49%
(RBC number X MCV) |
|
|
HCT in females (normal)
|
33-43%
(RBC number X MCV) |
|
|
MCV (normal)
|
76-100 fL
<70 microcytosis >100 macrocytosis |
|
|
MCH (normal)
|
27-33 pg
(HGB/RBC number) |
|
|
MCHC (normal)
|
33-37 gm/dl
(Hemoglobin Concentration/HCT X 100) (elevated in spherocytosis) (decreased in microcytic hypochromic anemias) |
|
|
RDW (normal)
|
11.5-14.5
|
|
|
t(9;22)
|
CML
(in anything else - poor prognosis) |
|
|
t(8;14)
|
Burkitt's Lymphoma
|
|
|
t(14;18)
|
Follicular Lymphoma
|
|
|
t(15;17)
|
AML - M3 (good prog)
|
|
|
t(1;14)
|
T-cell Lymphoblastic Lymphoma
|
|
|
t(11;22)
|
Ewing's Sarcoma
|
|
|
t(11;14)
|
Mantle Cell Lymphoma
|
|
|
t(11;18)
|
MALT Lymphoma
|
|
|
t(12;21)
|
ALL (good prognosis)
|
|
|
t(4;11)
|
ALL (poor prognosis)
|
|
|
PSA
|
Prostate Cancer
|
|
|
CEA
|
Colorectal
Pancreatic |
|
|
CA 19-9
|
Pancreatic
|
|
|
AFP
|
Hepatic
Yolk Sac |
|
|
BHCG
|
Choriocarcinoma
Molar Pregnancy (triploid fetus) |
|
|
CA 125
|
Ovarian Cancer
|
|
|
S-100
|
Melanoma
Astrocytoma |
|
|
Thyroglobulin
|
Thyroid Cancer
|
|
|
Calcitonin
|
Medullary Carcinoma of Thyroid
|
|
|
Catecholamines (blood)
Metanephrines (urine) |
Pheochromocytoma
Neuroblastoma |
|
|
TRAP stain
|
Hairy Cell Leukemia (acute)
(tartrate resistant acid phosphatase) |
|
|
Alkaline Phosphatase
|
Mets to bone
Paget's disease of bone |
|
|
Test for heriditary spherocytosis . . .
|
osmotic fragility
|
|
|
Difference between TTP and HUS . . .
|
HUS is similar but . . .
- no CNS problems - increased renal problems |
|
|
Drepanocytes
|
another term for sickle cells
(b/c "sickle cell" is too obvious) |
|
|
anisocytosis
|
size variation
|
|
|
poikliocytosis
|
shape variation
|
|
|
Leukemoid Reaction vs CML
|
LAP >100 - Leukemoid rxn
LAP <10 - CML |
|
|
What type of leukemia/lymphoma is:
PAS + MPO - |
ALL
|
|
|
What type of leukemia/lymphoma has auer rods?
|
AML (diagnostic)
- eosinophilic cytoplasmic deposit - made of azurophilic granules |
|
|
What are the two viruses associated with leuk/lymph?
|
EBV - Burkitts Lymphoma
EBV - PTLD (post transplant lymphoproliferative disorder) HTLV-1 - Tcell leuk/lymph (Also remember that H. Pylori is ac/w MALT Lymphoma) |
|
|
CD 5+ 23+
|
CLL/SLL
CD 5 - Tcell marker CD 23 - Bcell marker (shows neoplastic nature of cells) |
|
|
ALL vs CLL
|
acute versus indolent
acute process will respond to chemo acute has blastic, fine, delicate chromatin while chronic is condensed |
|
|
3 phases of CML
|
chronic <5%
accelerated 10-19% blast >20% |
|
|
4 main types of myeloproliferative disorders
|
Chronic myelogenous leukemia (myeloid)
Chronic idiopathic myelofibrosis (megakaryocytes) Essential thrombocytopenia (megakaryocytes) Polycythemia vera (RBCs) |
|
|
AML - M0
|
Minimally differentiated
(blasts lack myeloid features) |
|
|
AML - M1
|
Myeloid w/o maturation (20%)
- MPO+ |
|
|
AML - M2
|
Myeloid w/ maturation (30-40%)
- t(8;21) - good prognosis |
|
|
AML - M3
|
Promyelocytic
- complicated by DIC - t(15;17) - good prog |
|
|
AML - M4
|
Myelomonocytic
- NSE+ - inv 16 - good prog |
|
|
AML - M5
|
Monocytic
- t w/ 11q23 - bad prog |
|
|
AML - M6
|
Erythroid
|
|
|
AML - M7
|
Megakaryocytic
- ac/w Down synd. |
|
|
Leuk/lymph special stains
PAS MPO SBB NSE |
PAS - ALL
The rest are + in AMLs MPO - myeloblasts SSB - myelo + monoblasts NSE - monoblasts |
|
|
AML + Down Synd
|
AML - M7 (megakaryocytic)
|
|
|
AML complicated by DIC
|
AML - M3 (promyelocytic)
|
|
|
ALL vs AML
|
ALL - Childeren
AML - Adults Also in ALL MPO- PAS+ CD 10+ (aka CALLA) abrupt onset bone pain CNS involvement |
|
|
t(8;21)
|
AML - M2 (good prog)
|
|
|
inv 16
|
AML - M4 (good prog)
|
|
|
t w/ 11q23
|
AML - M5 (bad prog)
ALL - also bad prog (multilineage leukemia gene) |
|
|
Doehle bodies
|
dilated patches of ER
(what diseases) |
