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12 Cards in this Set
- Front
- Back
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what is the anticoagulant property of thrombin?
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- combines with thrombomodulin to activate protein C which is an inhibitor of thrombosis
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how does tissue factor pathway inhibitor (TFPI) work?
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- inhibits TF pathway - binds factor VII & FX to inhibit this pathway
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what factors do proteins C && S bind to?
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- FV & FVIII
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what are the 3 naturally occurring anti-coaggulants?
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1) TFPI
2) Anti-thrombin III 3) Protein C & S |
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what does thrombomodulin do?
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- inhibits thrombin, activates protein C & S
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what is virchows triad?
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- hypercoaguability (circulating blood coagulation factors & inhibitors)
- endothelial injury - hemostasis |
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what are some inherited reasons for thrombosis?
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- AT-III deficiency, factor V leiden deficiency, protein C & S deficiency, prothrombin deficiency
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what is factor V leiden deficiency?
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- most common --> activated protein C resistance (APC) --> changes FV ability to respond to protein C --> makes it prothrombotic
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what is antiphospholipid antibody syndrome?
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- acquired thrombophilia
- antibodies against proteins beta-glycoprotein & prothrombin - recurrent fetal loss because of arterial & venous thrombosis |
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what is livido retiruclaris and when does it occur?
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- looks like it's cold outside see all vessels
- occurs in antiphospholipid antibody syndrome |
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why is their prolongation of the assays in APLA syndrome?
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- because there is prothrombin in assay but it does not cause bleeding despite prolonged PTT!!!!
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how do you treat APLA?
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- if it is secondary to something (malignancy, lupus, etc) need to treat this!
- need to put patients on anti-coagulants |
