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85 Cards in this Set
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- Back
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Bendamustine
|
Treanda
|
ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. F:IV Indications: Lymphoma, CLL Toxicities: Myelosuppression GI toxicity (vomiting) |
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Busulfan
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Myleran
|
ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. F:IV, PO Indications: CML Toxicities: Myelosuppression GI toxicity (nausea, vomiting, diarrhea) Hepatotoxicity (veno-occlusive disease)-high dose CNS toxicity (seizure)-high dose Misc:rapid and complete oral absorption |
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Carboplatin
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Paraplatin
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ALKYLATING AGENT
Platinum Complex MOA: activated by aquation intracellularly (low Cl- concentration)-->react with DNA forming intrastand (favored) and interstrand cross-linked (adducts), N7 of guanine as the primary target, DNA adducts inhibit DNA replication and transcription leading to breaks and miscoding-->apoptosis Indications: lung, lymphoma, ovarian F: IV Toxicities: Myelosuppression- more severe Other toxicities less severe than cisplatin Misc: NOT cell cycle specific, NO aluminum needles or equipment preparing or administering all platinum-containing drugs, dose reduction for renal impairment |
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Chlorambucil
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Leukeran
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. Indications: CLL F: PO Toxicities: Myelosuppression Secondary malignancy (leukemia) |
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Cisplatin
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Platinol-AQ
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ALKYLATING AGENT
Platinum Complex MOA: activated by aquation intracellularly (low Cl- concentration)-->react with DNA forming intrastand (favored) and interstrand cross-linked (adducts), N7 of guanine as the primary target, DNA adducts inhibit DNA replication and transcription leading to breaks and miscoding-->apoptosis Indications:ovarian, testicular, lung, melanoma F:IV Toxicities: Nephrotoxicity, alleviated by chloride diuresis and amifostine (ETHYOL®) Neurotoxicity (peripheral neuropathy) Ototoxicity GI toxicity (severe vomiting and nausea), alleviated by aprepritant(EMEND®), dexamethasone and 5-HT3 antagonists Myelosuppression (mild to moderate)- mild compared to other agents and other toxicities Misc: NOT cell cycle specific, NO aluminum needles or equipment preparing or administering all platinum-containing drugs, mainly urine excretion |
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Cyclophosphamide
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Cytoxan, Neosar
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. Indications: Breast, ALL, CLL, Lung, Lymphoma F: PO, IV Toxicities: Myelosuppression (severe) GI toxicity (nausea, vomiting) Hemorrhagic cystitis-->due to accumulation of acrelein in the bladder , counteracted by mesna and diuresis (Mesna congregates w/acrelein--> reduce bladder toxicity) Cardiotoxicity (high doses) Secondary malignancy Misc: Phosphoramide mustard--> active metabolite--> anti-tumor effects |
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Dacarbazine
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DTIC-Dome
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. F:IV Indications: Lymphoma Toxicities: Myelosuppression GI toxicity (nausea, vomiting) |
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Ifosfamide
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Ifex
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. Indications: Lymphoma F: IV Toxicities: myelosuppression (more severe than CyPhos) hemorrhagic cystitis, alleviated by mesna and diuresis CNS toxicity (hallucination, coma) GI toxicity (nausea, vomiting) Misc: Much slower activation in the body, More lipophilic crosses BBB, metabolized by CYP3A4 to active form |
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Mechlorethamine
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Mustargen
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. Indications: Lymphoma F: IV Toxicities: Myelosuppression GI toxicity (nausea, vomiting) Misc: rapid iv injection (very unstable), chemical degradation (hydrolysis, deamination) in water and body fluids within minutes |
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Oxaliplatin
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Eloxatin
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ALKYLATING AGENT
Platinum Complex MOA: activated by aquation intracellularly (low Cl- concentration)-->react with DNA forming intrastand (favored) and interstrand cross-linked (adducts), N7 of guanine as the primary target, DNA adducts inhibit DNA replication and transcription leading to breaks and miscoding-->apoptosis Indications: colorectal, gastric F: IV Toxicities: Peripheral neuropathy- most severe GI toxicity (diarrhea, stomatitis, nausea, vomiting) myelosuppression (mild) Misc: NOT cell cycle specific, NO aluminum needles or equipment preparing or administering all platinum-containing drugs, DON’T use any chloride -containing solutions to reconstitute |
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Procarbazine
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Matulane
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ALKYLATING AGENT
Nitrogen Mustard MOA: Cytotoxic due to alkylation of DNA (neuclophilic attack of unstable aziridine ring by electron donor). N7 of guanine as the key target, causing interstrand cross-linkage of DNA chains. F: PO Indication: Lymphoma Toxicities: Myelosuppression GI toxicity (N/V) Secondary malignancy Misc: rapid and complete oral absorption |
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5-Fluorouracil
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5-FU, Adrucil, Efudex
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: incorporated into both DNA and RNA, blocks thymidylate synthesis (major) by inhibiting thymidylate synthase F:IV Indications: colorectal, breast Toxicities: Myelosuppression-major GI toxicity (nausea, vomiting, stomatitis, diarrhea) Hand-foot syndrome (palmar-plantar erythrodysesthesia) Misc: co-administration of leucovorin to enhance efficacy |
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Azacitidine
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Vidaza
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: Incorporates into DNA and inhibits methyltransferase, causing demethylation in DNA Indications: AML F: IV or SQ Toxicities: Myelosuppression Renal toxicity GI toxicity |
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6-Mercaptopurine
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Purinethol
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ANTI-METABOLITE AGENT
Purine Analog MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indication:ALL F: PO Toxicities: Myelosuppression- dose limiting Hepatotoxicity GI toxicity (nausea, vomiting, mucositis, stomatitis) Hyperuricemia, alleviated by allopurinol which inhibits xanthine oxidase to reduce the accumulation of uric acid , dose reduction by 75% Misc: first pass metabolism by xanthine oxidase (to uric acid), dose reduction for renal impairment |
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Capecitabine
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Xeloda
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: (Prodrug of 5-FU) incorporated into both DNA and RNA, blocks thymidylate synthesis (major) by inhibiting thymidylate synthase Indications: colorectal, breast F: PO Toxicities: GI toxicity (diarrhea, vomiting, nausea)- most severe b/c oral Hand-foot syndrome Myelosuppression Misc: dose reduction for renal impairment, Tumor specificity due to due high expression of thymidine phosphorylase in tumors and not in normal tissue= advantage over 5-FU |
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Cladribine
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Leustatin
|
ANTI-METABOLITE AGENT
Purine Analog MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indication: CLL, lymphoma F: IV Toxicities: Myelosuppression GI toxicity (nausea, vomiting) CNS toxicity (fever, chills) Renal toxicity |
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Clofarabine
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Clolar
|
ANTI-METABOLITE AGENT
Purine Analog MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indications: ALL F:IV Toxicities: Myelosuppression GI toxicity (nausea, vomiting, diarrhea) Capillary leak syndrome/systemic inflammatory response syndrome (SIRS) (vascular tone loss and extravasation of plasma fluids and proteins)=pain Hepatotoxicity |
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Cytarabine
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Ara-C, Cytosar-U
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: ara-CTP competes with dCTP for DNA incorporation, incorporated ara-CMP residues inhibit DNA polymerase, causes terminal differentiation of leukemic cells Indications: AML, ALL F: IV, IT Toxicities: Myelosuppression GI toxicity (diarrhea, mucositis, nausea, vomiting) CNS toxicity -high dose or intrathecal Misc: susceptible to cytidine deaminase(short t1/2), DEPOCYT: intrathecal liposomal formulation for sustained release in CSF (less CNS toxicity) |
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Decitabine
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Dacogen
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: incorporates into DNA and inhibits methyltransferase, causing demethylation in DNA Indication: AML F: IV Toxicities: Myelosuppression GI toxicity (nausea, vomiting, diarrhea) Misc: rapid deamination |
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Fludarabine
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Fludara
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ANTI-METABOLITE AGENT
Purine Analog (arabinoside, adenosine-analog) MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indication: AML, CLL F: IV, PO Toxicities: Autoimmune effects (hemolytic anemia) Myelosuppression GI toxicity (nausea, vomiting, diarrhea) CNS toxicity (chills, blindness, coma, seizure) Misc: dose reduction for renal impairment, adenosine deaminase- resistant due to presence of F at R1 |
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Gemcitabine
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Gemzar
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ANTI-METABOLITE AGENT
Pyrimidine Antagonists MOA: (tri-phosphorylated in vivo) dFdCTP competes with dCTP for DNA incorporation, inhibitor of DNA polymerase, dFdCDP inhibits ribonucleotide reductase Indications:breast, lung, pancreas, ovarian F: IV Toxicities(mild compared to others): Myelosuppression GI toxicity (nausea, vomiting, diarrhea) Hepatotoxicity Misc:extended infusion time increases dFdCTP formation |
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Hydroxyurea
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Hydrea
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ANTI-METABOLITE AGENT
MOA: inhibits ribonucleotide reductase--> block biosynthesis of DNA Indications: CML, Melanoma F: PO Toxicities: Myelosuppression Cutaneous vasculitic toxicity Secondary malignancy (leukemia) GI toxicity (stomatitis, diarrhea) Misc: majority eliminated in the urine= dose reduction for renal impairment |
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Methotrexate
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Folex, Rheumatrex
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ANTI-METABOLITE AGENT
Folic Acid analog MOA: dihydrofolate reductase ( DHFR ) inhibitor, MTX-PG is an inhibitor of DHFR, thymidylate synthase and de novo purine synthesis. Indications: ALL, breast, lymphoma F: IV Toxicities: Myelosuppression- dose limiting GI toxicity (nausea, vomiting, stomatitis) Nephrotoxicity (acute renal failure) Misc: dose reduction for renal impairment, toxicities rescued by leucovorin (folinic acid, N 5-formyl FH4), a reduced folate coenzyme. |
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Nelarabine
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Arranon
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ANTI-METABOLITE AGENT
Purine Analog MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indications: ALL, lymphoma F: IV Toxicities: Myelosuppression Neurotoxicity (seizure, peripheral neuropathy) GI toxicity (nausea, diarrhea, vomiting) Misc: hepatic metabolism to form ara-G (active form) |
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Pemetrexed
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Alimta
|
ANTI-METABOLITE AGENT
Folic Acid analog MOA: dihydrofolate reductase ( DHFR ) inhibitor, more potent inhibitor of de novo purine synthesis (main mech) Indications: lung, breast, pancreas, renal, head & neck F:IV Toxcities: myelosuppression GI toxicity (nausea, vomiting, stomatitis, diarrhea) nephrotoxicty dermotogical reactions Misc: dose reduction for renal impairment,better transported into tumor cells than MTX |
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Pentostatin
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Nipent
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ANTI-METABOLITE AGENT
Purine Analog MOA: inhibits de novo synthesis of purine bases and nucleotides, triphosphate derivatives incorporated into DNA Indications: CLL, lymphoma F: IV Toxicities: GI toxicity (N/V, diarrhea, stomatitis) myelosuppression |
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Irinotecan
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Camptosar, CPT-11
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TOPOISOMERASE I INHIBITOR
Camptothecin Analog MOA: The flat ring systems intercalate DNA at the site of cleavage, Bind and stabalize DNA-topoisomerase I “cleavable complex”, Inhibit the religation of single- stranded breaks in DNA, Cause irreversible DNA break during DNA replication, leading to apoptosis. Indication: lung, colorectal, cervical, ovarian, gastric, brain F:IV in polysorbate 80 Toxicities: Diarrhea- most sig Myelosuppression Hypersensitivity reactions- caused by polysorbate 80 (pretreat w/dexamethasone and antihistamines) Misc: metabolized by hepatic carboxylesterase to SN-38 (active), SN-38 is less hydrolyzed due to high plasma protein binding, dose reduction for hepatic impairment |
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Topotecan
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Hycamtin
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TOPOISOMERASE I INHIBITOR
Camptothecin Analog MOA: The flat ring systems intercalate DNA at the site of cleavage, Bind and stabalize DNA-topoisomerase I “cleavable complex”, Inhibit the religation of single- stranded breaks in DNA, Cause irreversible DNA break during DNA replication, leading to apoptosis. Indication: lung, ovarian F:IV Toxicities: Myelosuppression GI toxicity (diarrhea, nausea, vomiting) Misc: 5 fused ring structure is signature for these compounds,spontaneous hydrolysis in whole blood forms less active metabolite= main metabolic pathway, dose reduction for renal impairment |
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Daunorubicin
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Cerubidine
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TOPOISOMERASE II INHIBITOR
Anthracycline MOA: flat ring system intercalates directly with DNA, forms a complex with topoisomerase II and DNA, causing double-stranded DNA breaks, leading to apoptosis Indications: AML, ALL F:IV Toxicities: Myelosuppression Cardiotoxicity Vesicant GI toxicity (nausea, vomiting, stomatitis) Misc: hepatic metabolism (active metabolite), red-colored urine, dose reduction for renal impairment |
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Doxorubicin
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Adriamycin
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TOPOISOMERASE II INHIBITOR
Anthracycline MOA: flat ring system intercalates directly with DNA, forms a complex with topoisomerase II and DNA, causing double-stranded DNA breaks, leading to apoptosis Indications: breast, ALL, lung, lymphoma, ovarian F: IV Toxicities: Myelosuppression- dose limiting Cardiotoxicity (avoid combination with cyclophosphamide, other anthracyclines or herceptin) Counteracted by concomitant use of dexrazoxane Potent vesicant- causes pain in surrounding tissue GI toxicity (nausea, vomiting, ulceration) Secondary malignancy (AML) Misc: dose reduction for hepatic impairment, rapid uptake in heart, kidney, lung, liver and spleen |
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Epirubicin
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Ellence
|
TOPOISOMERASE II INHIBITOR
Anthracycline MOA: flat ring system intercalates directly with DNA, forms a complex with topoisomerase II and DNA, causing double-stranded DNA breaks, leading to apoptosis Indications: BREAST, cervical, gastric F: IV Toxicities: myelosuppression cardiotoxicity Vesicant GI toxicities (nausea, vomiting, diarrhea) Secondary malignancy (AML) Misc: dose reduction for hepatic impairment, dose reduction for renal impairment, can cause red urine |
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Etoposide
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VP-16, Vepesid
|
TOPOISOMERASE II INHIBITOR
Epipodophyllotoxin MOA: forms a ternary complex with topoisomerase II and DNA causes double-stranded DNA breaks, most sensitive in cells during S and G2 phases Indications: lung, lymphoma, testicular F: IV Toxicities: Myelosuppression GI toxicities (nausea, vomiting, diarrhea) Hepatotoxicity Hypersensitivity Misc: dose reduction for renal impairment, polysorbate 80 as vehicle |
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Idarubicin
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Idamycin PFS
|
TOPOISOMERASE II INHIBITOR
Anthracycline MOA: flat ring system intercalates directly with DNA, forms a complex with topoisomerase II and DNA, causing double-stranded DNA breaks, leading to apoptosis Indications: AML, ALL F: IV Toxicities: Myelosuppression Cardiotoxicity Vesicant GI toxicity (nausea, vomiting, diarrhea) Misc: dose reduction for hepatic impairment |
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Mitoxantrone
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Novantrone
|
TOPOISOMERASE II INHIBITOR
Anthracycline MOA: flat ring system intercalates directly with DNA, forms a complex with topoisomerase II and DNA, causing double-stranded DNA breaks, leading to apoptosis Indications: prostate, lymphoma F: IV Toxicities: Myelosuppression Less cardiotoxicity and other toxicities than true anthracyclines GI toxicity (nausea, vomiting, diarrhea) Vesicant secondary malignancy (AML) Misc: Doesn’t have glycoside like other anthracyclines |
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Teniposide
|
Vumon
|
TOPOISOMERASE II INHIBITOR
Epipodophyllotoxin MOA: forms a ternary complex with topoisomerase II and DNA causes double-stranded DNA breaks, most sensitive in cells during S and G2 phases Indications: lymphoma, lung, pediatric ALL F: IV Toxicities: Myelosuppression Hypersensitivity reactions GI toxicities (nausea, vomiting) Misc: Cremophor EL as vehicle |
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Cabazitaxel
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Jevtana
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MICROTUBULE TARGETING AGENT
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Docetaxel
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Taxotere
|
MICROTUBULE TARGETING AGENT
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Eribulin
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Halaven
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MICROTUBULE TARGETING AGENT
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Estramustine
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Emyct
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MICROTUBULE TARGETING AGENT
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Ixabepilone
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Ixempra
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MICROTUBULE TARGETING AGENT
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Paclitaxel
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Taxol
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MICROTUBULE TARGETING AGENT
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Paclitaxel-protein bound
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Abraxane
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MICROTUBULE TARGETING AGENT
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Vinblastine
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Velban
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MICROTUBULE TARGETING AGENT
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Vincristine
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Oncovin, Vincasar
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MICROTUBULE TARGETING AGENT
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Vindesine
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Eldisine
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MICROTUBULE TARGETING AGENT
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Vinorelbine
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Navelbine
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MICROTUBULE TARGETING AGENT
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Erlotinib
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Tarceva
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TYROSINE KINASE INHIBITOR
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Dasatinib
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Sprycel
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TYROSINE KINASE INHIBITOR
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Gefitinib
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Iressa
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TYROSINE KINASE INHIBITOR
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Imatinib
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Gleevec
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TYROSINE KINASE INHIBITOR
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Lapatinib
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Tykerb
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TYROSINE KINASE INHIBITOR
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Nilotinib
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Tasigna
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TYROSINE KINASE INHIBITOR
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Vemurafenib
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Zelboraf
|
TYROSINE KINASE INHIBITOR
|
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Crizotinib
|
Xalkori
|
TYROSINE KINASE INHIBITOR
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All-trans retinoic acid
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Vesanoid, ATRA
|
DIFFERENTIATION AGENT
MOA: promotes the degradation of PML-RAR-a fusion protein, displaces co-repressors of differentiation Indications: AML (APL) F: PO Toxicities: APL differentiation syndrome (retinoic acid-APL syndrome): fever, weight gain, pulmonary infiltrates, pleural or pericardial effusion, multi-organ failure Leukocytosis (opposite of myelosuppression) Hepatotoxicity Cardiovascular toxicity (edema, thrombosis) GI toxicity (nausea, vomiting, diarrhea, hemorrhage) |
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Arsenic trioxide
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Trisenox
|
DIFFERENTIATION AGENT
MOA: promotes the degradation of PML-RAR-a fusion protein, generates free radicals and inhibits angiogenesis Indications: AML (APL) F: IV Toxicities: APL differentiation syndrome Leukocytosis Cardiotoxicity (QT prolongation)- due to metal moiety Electrolyte imbalance GI toxicity (nausea, vomiting, diarrhea) |
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Bortezomib
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Velcade
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Misc Agent
MOA: 26S proteosome inhibitor, causing inactivation of NF-kB Indications: multiple myeloma, lymphoma F: IV or SQ Toxicities: Peripheral neuropathy Myelosuppression GI toxicity (nausea, vomiting, diarrhea, constipation) Misc: dose reduction for hepatic impairment |
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Thalidomide
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Thalomid
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Misc Agent
MOA: (unclear) G1 arrest, apoptosis, inhibits cell adhesion, decreases angiogenesis, increases NK cell activity Indications: multiple myeloma F:PO Toxicities: Severe birth defect, teratogen Myelosuppression Deep vein thrombosis and pulmonary embolism neurotoxicity (peripheral neuropathy , sedation, seizure) GI toxicity (constipation, nausea) |
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Lenalidomide
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Revlimid
|
Misc agent
MOA: (unclear) G1 arrest, apoptosis, inhibits cell adhesion, decreases angiogenesis, increases NK cell activity Indications: multiple myeloma F: PO Toxicities: Myelosuppression-serious Other toxicities less severe than thalidomide |
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L-asparaginase
|
Elpsar
|
Misc agent
MOA: deprives tumor cells that relay on exogenous L-asparagine, inhibits protein synthesis and causes cell death Indications: ALL F: IV or IM Toxicities: Hypersensitivity reactions Hepatotoxicity Inhibition of protein synthesis, leading to: hyperglycemia (dec insulin) clotting abnormalities (dec clotting factors) hypertrigleridemia (dec lipoprotein), pancreatitis |
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Bleomycin
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Blenoxane
|
Misc agent
MOA: cause single- and double-stranded DNA breaks Indications: lymphoma, melanoma, testicular F: IV, IM, or SQ Toxicities: Pulmonary fibrosis- dose dependant/limiting Cutaneous reactions (hyperpigmentation, erythema, ulceration) Hypersensitivity reactions Hepatotoxicity Misc: dose reduction for renal impairment, Maximum cumulative lifetime dose: 400 unit*** |
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Abarelix
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Plenaxis
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ANTI-HORMONAL AGENT
|
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Anastrazole
|
Arimidex
|
ANTI-HORMONAL AGENT
|
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Bicalutamide
|
Casodex
|
ANTI-HORMONAL AGENT
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Exemestane
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Aromasin
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ANTI-HORMONAL AGENT
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Flutamide
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Eulexin
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ANTI-HORMONAL AGENT
|
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Fulvestrant
|
Faslodex
|
ANTI-HORMONAL AGENT
Selective estrogen-receptor downregulator (SERD), pure anti-estrogen MOA: inhibit ER dimerization and increase its degradation Indications: ER-positive breast cancer, postmenopausal F: IM Toxicities: Hot flashes, nausea, vomiting, headache Misc: effective in tamoxifen-resistant cells |
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Goserelin
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Zoladex
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ANTI-HORMONAL AGENT
LHRH Agonist MOA: Suppression of ovarian due to decreased levels of LH and FSH with subsequent decrease in estrogen in women |
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Letrozole
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Femara
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ANTI-HORMONAL AGENT
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Leuprolide acetate
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Lupron Depot, Viadur, Eligard
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ANTI-HORMONAL AGENT
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Megestrol Acetate
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Megace
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ANTI-HORMONAL AGENT
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Nilutamide
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Nilandron
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ANTI-HORMONAL AGENT
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Raloxifene
|
Evista
|
ANTI-HORMONAL AGENT
Selective Estrogen Receptor Modulators (SERMs) MOA: downregulate ER (anti-estrogenic in breast cells, estrogenic in uterus (endometric cells)) Indications: ER+ breast cancer F: po Toxicities: Increased risk for stroke in patients with coronary heart disease Increased risk for thromboembolic disease Hot flashes, edema, vaginal bleeding, vomiting Misc: extensive first-pass effect |
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Tamoxifen
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Nolvadex
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ANTI-HORMONAL AGENT
Selective Estrogen Receptor Modulators (SERMs) MOA: downregulate ER (anti-estrogenic in breast cells, estrogenic in uterus (endometric cells)) Indications: ER+ breast cancer F: po Toxicities: Increased risk for uterine (endometric) cancer Thromboembolic events (stroke, pulmonary) Occular toxicity Hepatotoxicity Decreased bone mineral density in premanopausal patients Hot flashes, edema, vaginal bleeding, nausea |
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Toremifene
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Fareston
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ANTI-HORMONAL AGENT
Selective Estrogen Receptor Modulators (SERMs) MOA: downregulate ER (anti-estrogenic in breast cells, estrogenic in uterus (endometric cells)) Indications: ER+ breast cancer (postmenopausal) F: po Toxicities: Hot flashes, nausea, vaginal discharge |
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Degarelix
|
Firmagon
|
ANTI-HORMONAL AGENT
|
|
Alemtuzumab
|
Campath
|
MONOCLONAL ANTIBODY
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Bevacizumab
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Avastin
|
MONOCLONAL ANTIBODY
|
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Cetuximab
|
Erbitux
|
MONOCLONAL ANTIBODY
|
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Ipilimumab
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Yervoy
|
MONOCLONAL ANTIBODY
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Pantimumab
|
Vectibix
|
MONOCLONAL ANTIBODY
|
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Rituximab
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Rituxan
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MONOCLONAL ANTIBODY
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Trastuzumab
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Herceptin
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MONOCLONAL ANTIBODY
|
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Brentuximab Vedotin
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Adcetris
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MONOCLONAL ANTIBODY
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Ofatumumab
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Arzerra
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MONOCLONAL ANTIBODY
|