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CONGENITAL NEUTROPENIA

Cyclic neutropenia
21 day cycle - numbers of PMNs and monos drop every 21 days.
CONGENITAL NEUTROPENIA

Severe congenital neutropenia (SCN)
Multiple subtypes mostly with static neutropenia.

Can't make neutrophils
CONGENITAL NEUTROPENIA

Kostmann
Infantile agranulocytosis presenting with multiple severe infections

Very low neutrophil counts.
CONGENITAL NEUTROPENIA

Chediak-Higashi
Neutropenia, giant lysosomes, oculocutaneous albinism, lymphoma-like syndrome.
Most common causes of neutrophilia
>10000

smoking and obesity.
What is the first myeloid cell line seen after chemotherapy ablates BM?
Monocytes.