Hematology I

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Pelger-Huet Anomaly/Pince-Nez Cell

Benign congenital hypo segmentation of PMNs.

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Alder-Reilly Inclusions/Anomaly

Hematological manifestation of a group of inherited recessive disorders. Deficiency in enzymes to break down mucopolysaccharides. Hurlers syndrome.

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Toxic Granulation

Stimulation of granulocytic cells results in fewer mitotic divisions. Prevents normal dilution of nonspecific granules. Severe bacterial infection or toxicity.

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Chediak Higashi Syndrome

Rare autosomal recessive disorder, giant lysosomes in most cells of body. Abnormally formed lysosomal granules in WBC. Decreased platelets with abnormal large granules and defective function.

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Gaucher's Disease or Gaucher's Cell

Inability to degrade glucocerebroside. Deficient beta-glucocerebrosidase.

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Pyknotic Degeneration

Cells undergoing apoptosis. Nuclear material loses chromatin pattern.

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May-Hegglin Anomaly

Hematological manifestation. Rare autosomal dominant condition. Dohle like bodies not RNA.

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Flame Cell

Plasma cell producing IgA. Brilliant red staining cytoplasm from IgA.

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Septicemia

Bacteria in blood.

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Barr Bodies

Extra X-chromosome unnecessary for normal nuclear function.

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Toxic Vacuoles

Clear holes in cytoplasm of phagocytic cells. Toxic is increased vacuolization-more than normal. Severe bacterial infections or toxic states.

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Reactive Lymph

Activated T Lymph. Viral infections.

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Hyper-segmentation

Congenital or megaloblastic change.

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Dohle Bodies

Remnant RNA. Toxic granulation, toxic vacuoles, shift left.

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Foam Cell

Niemann Pick Disease. Inability to degrade sphingomyelin, accumulates in spleen, liver, lungs, brain, BM. Deficient enzyme, sphingomyelinase.

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Smudge Cell

Cells destroyed making peripheral smear. Increased cell fragility. Can add albumin.

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Russel Bodies/Mott Cell

Bright red or white globular inclusions of Ig in cytoplasm.

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Tay-Sachs Disease

Accumulation of un-metabolized ganglioside in almost all tissues. Deficient enzyme, hexosaminidase A.