Hematology Comp

Front 1

what are the structures seen highlighted by the arrows?

Back 1

Dohle bodies

Front 2

what are the structures seen in the WBC?

Back 2

Heinz Bodies

Front 3

What is the long light blue structure observed in the Seg neutrophil?

Back 3

May-Hegglin anomaly

Front 4

These two segmented neutrophils containing lysosomal granules are characteristic of what disease?

Back 4

Chediak Higashi syndrome

Front 5

In pseudogout, what actually are the crystals you observe in syndovial fluid?

Back 5

calcium pyrophosphate, NOT monosodium urate

Front 6

Which lab test will distinguish hemophilia A from B?

Back 6

APTT

Front 7

which anticoagulant is most commonly used for hemostasis testing?

Back 7

sodium citrate (light blue)

Front 8

which side is the cathode?

Back 8

negative (-) side

Front 9

which side is the anode ?

Back 9

positive (+) side

Front 10

define myelodysplasia

Back 10

a qualitative disorder of erythroid, myeloid, and or megakaryocytic lines. bone marrow is unable to produce these lines due to a qualitative or qualititative defect an can lead to AML

Front 11

these two neutrophils exhibit hyposegmentation. what is this disorder called?

Back 11

Pelger huet anomaly

Front 12

The cell above is in the myelogenous line. What is this cell according to maturation?

Back 12

Myeloblast

Front 13

the cell is in the myelogenous line. what is the cells maturation name?

Back 13

Promyelocyte

Front 14

this is in a myelogenous cell line. what is this cell according to maturation?

Back 14

myelocyte

Front 15

large platelets, adnormal screening tests for platelet function and moderate/severe thrombocytopenia are all characteristic of what disorder?

Back 15

Bernard Soulier syndrome

Front 16

the following was observed in synovial fluid. what are the foamy cells observed?

Back 16

synovial lining cells

Front 17

a dissolution of a clot using 5M urea indicates what deficiency?

Back 17

von Willebrand disease

Front 18

What factor is known as Stable Factor?

Back 18

factor VII

Front 19

What factor is known as Anti-hemophilic Factor?

Back 19

factor VIII

Front 20

What factor is known as Christmas Factor?

Back 20

factor IX

Front 21

What factor is known as Stuart Factor?

Back 21

factor X

Front 22

Other than a genetic sickle cell disease, what can cause a sickling event?

Back 22

temp influctuations

Front 23

fibrin clots are stablized by what two hematological necessities?

Back 23

cross linked fibrin strands and factor XIII (13)

Front 24

Hemoglobin begins to form in which stage of the erythroid line?

Back 24

polychromatic normoblast

Front 25

which beta thalassemia (minima, minor, intermedia, or major) are nRBCs likely to be seen?

Back 25

Beta Thalassemia Major

Front 26

What disease is the Philidelphia Chromosome related to?

Back 26

CLL

Front 27

in hemoglobin determination, Drakins solution is used to measure what type of hemoglobin?

Back 27

Cyanmethemoglobin

Front 28

what plasmodium species is noted if 15 paracites are observed in a single schizont with schauffners dots?

Back 28

P. vivax

Front 29

what plasmodium species is noted if only a max of 8 paracites are observed in a single schizont?

Back 29

P. malariae

Front 30

what plasmodium species is noted if only banana shaped gametocytes are observed

Back 30

P. falciparum

Front 31

what plasmodium species is noted if the slanted ring shape is observed in the RBC?

Back 31

P. ovale

Front 32

What is the unusual projection on the top end of the neutrophils nucleus?

Back 32

Barr body

Front 33

what lab findings are expected in a patient experiencing HH (hereditary hemochromatosis)?

Back 33

elevated transferrin sat
presence of HFE mutation
elevated serum ferriten

Front 34

What are the dark RBC inclusions in this photo?
what are they made of?

Back 34

Howell Jolly Bodies
erythrocyte nuclei, nuclear fragments and aggregates of chromosomes

Front 35

What is the best way to characterize syndovial fluid?

Back 35

polarized light

Front 36

A 5 month old child has over 50% lymphs in circulation. what is notable about this finding?

Back 36

Nothing, this is typically normal for a young child (under 6 months)

Front 37

which cells typically have the most scatter when analyzed using flow cytometry?

Back 37

granulocytes

Front 38

What is a synonym for Beta Thalassemia?

Back 38

Cooleys anemia!

Front 39

What chans make up hemoglobin H?

Back 39

4 beta chains!

Front 40

what kind of cells are associated with Hodgkin Lymphoma?

Back 40

Reed sternburg cells!

Front 41

Identify the very large, double nucleated cells in the middle of this asperate.

Back 41

Reed Sternburg cells

Front 42

Why is the presence of schistocytes justified in alpha Thalassemia patients?

Back 42

the hemoglobin tetrameres can cause damage to the RBC. the schistocyte represents that something is causing the RBC to be damaged

Front 43

what is the main function of the hexose monophosphate shunt in the RBC?

Back 43

to provide reduced glutathione to prevent oxydation of hemoglobin

Front 44

hypersegmentation of the granulocyte is generally a signal of what?

Back 44

Vit B12 or folate deficiency aka from a megaloblastic anemia

Front 45

in which thalassemia would you expect to see 100% heoglobin F?

Back 45

delta-beta thal major? wtf

Front 46

what cells are a give away that a hemolytic anemia may be in effect?

Back 46

spherocytes

Front 47

indicate which lab results one would expect in the case of beta thal minor?
RBC
Hgb
RBC morph

Back 47

RBC count- increased
Hgb- normal or slight decreased
RBC morph- codocytes, basophilic stippling, microcytes

Front 48

in the case of Rouleaux, what other abnormal finding would one expect?

Back 48

increased sed rate

Front 49

tear drop cells can be associated with these three diseases?

Back 49

myelofibrosis, thalassemia and myelophthisis

Front 50

what kind of RBC morphology is associated with abetalipoproteinemia?

Back 50

acanthocytes generally accompany lipid disorders

Front 51

alpha thalassemias can form which hemoglobins?

Back 51

Hgb Barts and Hgb H

Front 52

what does polikocytosis mean?

Back 52

differentiation in RBC shape

Front 53

the banded neutrophil is exhibiting what anomaly?

Back 53

cytotoxic granulation

Front 54

define anisocytosis

Back 54

variation of RBC size

Front 55

What is brilliant Cresyl blue stain used for?

Back 55

reticulocytes

Front 56

how do you determine the calculation on a hemocytometer?

Back 56

WBC count= (dilutionx # counted cells x 10) / [# mm^2]

Front 57

which conditions would you associate with a g6pd deficiency?

Back 57

precipitation of hemoglobin

Front 58

what is the coding for alpha hemoglobin chains?

Back 58

4 gene loci, two each on chromosome 16

Front 59

This giant multinucleated cell was seen in the cerebrospinal fluid. what is it?

Back 59

multinucleated histocyte

Front 60

How do you calculate MCV?

Back 60

[(HCT%)/ (rbc/L)] x 10

Front 61

How do you calculate MCH?

Back 61

(Hgb/RBC) x 10

Front 62

how do you calculate MCHC?

Back 62

(hgb/hct) x100

Front 63

What is the formula for correcting the WBC count?

Back 63

WBC count corrected= uncorrected count x (100/nRBCs +100

Front 64

What test can you run to determine if a fetus has Down syndrome or a Open Neural Tube defect?

Back 64

mothers alpha fetoprotein

Front 65

What is this cell? what are the dropelets made of? what is it suggestive of?

Back 65

Mott Cell
Droplets are Russel bodies aka mucopolysaccharides
suggestive of Multiple Myeloma

Front 66

What is a common RBC morphology finding in patients with Multiple Myeloma?

Back 66

Rouleaux

Front 67

Which B cell markers indicate that the B cell is fully matured?

Back 67

markers 19, 20 and K or L

Front 68

which test is used to monitory oral anticoagulation therapy?

Back 68

Prot

Front 69

What factors are in the intrinsic pathway?

Back 69

XII, XI, VIII, IX

Front 70

what factors are in the extrensic pathway?

Back 70

VII

Front 71

What factors are in the common pathway?

Back 71

X, II, V, XIII

Front 72

What happens to Erythrocytes during the staining process for flow cytometry?

Back 72

they are lysed

Front 73

When is a LAP stain necessary?

Back 73

to determine if the increase in myelogenous cells are infectious or cancerous (CML versus infection)

Front 74

what are the RBC inclusions shown and what are they made from?

Back 74

Pappenheimer bodies are siderotic granules

Front 75

What is the most common early abnormality observed in lymphnodes of AIDS patients?

Back 75

reactive lymphadenopathy

Front 76

Which two stains are routine for bone marrow slide preps?

Back 76

Prussian blue and Romanosky

Front 77

which virus is most often reported as the cause of infection leading to aplastic crisis in a patient with sickle cell disease?

Back 77

Parvovirus B19

Front 78

what is this cell?

Back 78

plasma cell

Front 79

what is the interpretation if cells stain positive with acid phosphate and are NOT inhibitied with tartrate?

Back 79

positive TRAP test
Hairy Cell Leukemia

Front 80

What causes are linked to basophilic stippling?

Back 80

reticulocytosis as a result from hemolytic anemia, megaloblastic anemia, lead poisoning and thalassemias

Front 81

What is the HFE genotype that is most common in patients with hereditatry hemochromatosis (HH)?

Back 81

homozygous for C282Y

Front 82

How do you monitor warfarin based oral anticoagulant therapy?

Back 82

PT/INR

Front 83

What is an FDA approved therapeutic angent for treating sickle cell patients?

Back 83

hydroxyurea

Front 84

associate three causes with RBC macrocytosis

Back 84

alcohol, hypothyroidism and b12 def

Front 85

what lab finding will mark the end of the initial phase of HH treatment?

Back 85

when serum ferritin decreases between 20-50 ng/ml

Front 86

is the tube on the left or the right positive for sickle?

Back 86

right- turbitity is a positive interpretation for sickle cell disease

Front 87

which CD marker is associated with stem cells?

Back 87

CD34

Front 88

If the patient has RBCs containing Hgb S what will induce the sickling phenomenon?

Back 88

a reducing agent will trigger the sickling phenomenon

Front 89

Protein C, Protein S and antithrombin III all cause (hyper or hypo) coagulability?

Back 89

Hypercoagulability or thrombitic tendencies

Front 90

the beta chain is on the same loci as which two other genes?

Back 90

delta and gamma

Front 91

what is the mechanism of heparin induced thrombocytopenia?

Back 91

Ab directed against platelet factor 4 (PF4) and heparin complex

Front 92

What radioactive method isotope is used to measure red cell survival?

Back 92

Cr51

Front 93

What two disease are associated with macrocytic anemias?

Back 93

pernicious anemia and folic acid def anemia

Front 94

which two diseases are associated wtih microcytic hypochromic anemias?

Back 94

Coolies anemia (Beta thalassemia) and iron def anemia

Front 95

which cells express CD 3 and CD4?

Back 95

Cd3- all T cells
CD4- only T helper cells

Front 96

What is the pathophysiology of the iron overload in hereditary hemochromatosis?

Back 96

absorption of excess amounts of iron in the small intestine

Front 97

In HH what is the most common early symptom?

Back 97

joint pain