• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/14

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

14 Cards in this Set

  • Front
  • Back
Describe the lineage of a mature RBC and discuss other paths hematopoietic stem cells can go. Also mention specific cytokines involved
Describe erythropoiesis
What does a reticulocyte look like?
Describe the regulation of erythropoiesis.
1. EPO is a glycoprotein in the kidney that is stimulated by low O2 saturation
2. EPO stimulates proliferation of BFU-E and CFU-E, also accelerates bone marrow erythroid proliferation, and Hb formation and Fe utilization
What are the 4 essential requirements of RBC production?
1. Fe
2. AAs
3. Folic Acid
4. B12 (cobalamin)
5. B6 (pyridoxine)
Describe Fe transport
What molecule acts as the storage form of insoluble iron?
1. Hemosiderin
Describe how Fe enters and leaves the duodenal cell.
Describe the synthesis of hemoglobin.

**include heme synthesis and globin synthesis in general**
Describe how Hepcidin acts as a negative iron regulator
Describe O2 dissociation curve and what effects it.
Describe the basic structure of the RBC cytoskeleton.
Contents
1. Ankyrin
2. Alpha and beta spectrin
3. Actin
4. Tropomyosin
5. Band 3
6. Adducin
What functions do ATP, NADH, 2,3-DPG, NADPH, and GSH contribute to RBC metabolism?
1. ATP - energy
2. NADH - maintain reduced form of Fe
3. 2,3-DPG - enhance O2 release under low O2 tension
4. NADPH and GSH - removal of toxic oxidants and prevent denaturation of globin
Describe the recycling process of RBC components
1. The protoporphyrin ring is broken releasing CO and FE (tetrapyrrole ring too)
2. Unconjugated bilirubin travels to the liver via albumin, then conjugated
3. conjugated bilirubin is converted to urobilinogen which is excreted in the stool or reabsorbed