Agacnp 2016 Review Hematologic Disorders

Front 1

Hgb value norm

Back 1

12-18

Front 2

Hct value norm

Back 2

% = 37-54

Front 3

TIBC norm

Back 3

250-450

Front 4

MCV norm

Back 4

80-100

Front 5

MCHC norm

Back 5

32-36%

Front 6

Low MCV indications.

Back 6

Iron deficiency anemia

Thalassemia

Front 7

High MCV indications

Back 7

B12 or Folate deficiency

ETOH

Liver failure

Drugs

Front 8

Normocytic anemia differentials

Back 8

Chronic disease

sickle cell

renal failure

blood loss

hemolysis

Front 9

Iron deficiency anemia blood size and color

Back 9

Microcytic hypochromic

Front 10

Most common cause of amemia?

Back 10

Iron deficiency

Front 11

S/s of IDA

Back 11

Pica

Dyspnea and mild fatigue

HA

Palpitations

Tachy

Pallor

Front 12

What does ferritin show?

Back 12

Iron stores (norm 18-270)

Front 13

In IDA what will IIBC be?

Back 13

High = more binding room

Front 14

Tx of IDA

Back 14

Oral iron (not with antacids)

Take with vitamin C to increase absorption

Front 15

Size & color in Thalassemia?

Back 15

Micro hypo

Front 16

Which populations see more Thalassemia?

Back 16

Mediterranean, African, Indian, Middle Eastern, Asian

Front 17

What will TIBC be in Thalassemia?

Back 17

Normal (250-450)

Front 18

What will ferritin be in Thalassemia?

Back 18

Normal

Front 19

Normal Serum Iron level

Back 19

50-150

Front 20

What happens in Thalassemia?

Back 20

Abnormal Hgb production

Front 21

Folic acid defeciency appearance?

Back 21

Macro Normo

Front 22

Cause of Folic Acid deficiency ?

Back 22

Poor intake ETOH

Front 23

Difference between folic acid and B 12 ?

Back 23

No neuro s/s in Folic Acid

Front 24

Pernicious Anemia appearance

Back 24

Macro Normo

Front 25

Cause of pernicious anemia?

Back 25

Malabsorption of B12

Front 26

s/s of Pernicious Anemia

Back 26

Weakness

Glossitis (red beefy)

Palpatations

Paresthesias

Loss of fine motor control

+ Romberg and Babinski

Front 27

Tx for pernicious Anemia

Back 27

B12 IM daily x1 week

Lifelong monthly tx

Front 28

Anemia of chronic disease appearance

Back 28

Normo normo

Front 29

Differentials for ACD

Back 29

Chronic inflammation

Infection

Renal failure

Malignancy

Front 30

TIBC in ACD

Back 30

Low

Front 31

Serum Iron in ACD

Back 31

Low

Front 32

Serum Ferritin in ACD

Back 32

High

Front 33

Tx ACD

Back 33

Nutrition

Tx underlying disease

Epopoeitin

Front 34

Supplement Iron in ACD?

Back 34

No, ferritin is high

Front 35

Idiopathic Thrombocytopenia Purpura (ITP) description

Back 35

Autoammore destruction of platelets

Front 36

Idiopathic Thrombocytopenia Purpura (ITP) labs and signs

Back 36

Bleeding gums, easy bruising, kidney bleeding

Bone marrow analysis

low platelets with all other causes R/0

Front 37

Idiopathic Thrombocytopenia Purpura (ITP) TX

Back 37

High dose corticosteroids

IV gamma globulin

platelet transfusion

Front 38

Heparin-induced Thrombocytopenia TX

Back 38

Give Argatroban or Lepiratin

Need bone marrow aspiration to distinguish from ITP

Front 39

DIC patho

Back 39

Coagulation factors are used in clotting the thrombin also activates the fibrinolytic system and dissolves clots into fibrin degredation products (FDP)

Results in clotting and diffuse bleeding High mortality

Front 40

DIC Labs

Back 40

Platetet <150

Fibrinogen < 170

Low RBC

*Increased FDP > 45

PT >19

PTT >42

D-Dimer elevated

Front 41

DIC transfusion products and rationale

Back 41

Platelet = thrombocytopenia

FFP= replace clotting factors

Cryoppt = replace fibrinogen

Front 42

Sideroblastic anemia

Back 42

Microcytic

normal TIBC