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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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As early as ___ of gestation in the blood islands of the _____ of the human embryo. Confined to erythropoiesis (_______ ________). Production of primitive cells containing embryonic hemoglobins |
19th, yolk sac, primitive hematopoiesis |
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Portland: 2 zeta + 2 gamma Gower 1: 2 zeta + 2 epsilon Gower 2: 2 alpha + 2 epsilon |
Primitive cells containing embryonic hgbs |
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Hepatic phase |
Start of Definitive Hematopoiesis @ 3rd month, fetal liver becomes active Production of erythrocytes AND granulocytes |
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Hgb F (2 alpha + 2 gamma) Hgb A (2 alpha + 2 beta) Hgb A1 (2 alpha + 2 delta) |
Definitive erythroblasts containing fetal hgbs |
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Components (Direct Plt Determination Rees-Ecker: Guy & Leake: Brecker-Cronkite: Unopette: |
RE: sodium citrate, formalin, brilliant cresyl blue GL: sodium oxalate, formalin, crystal violet BC: EDTA, 1% ammonium oxalate (to lyse rbc); use phase contrast microscopy U: 1% ammonium oxalate |
Unopette: Diluent - 1.98mL Blood - 0.02mL Total Volume: 2mL Dilution (1:100) |
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Between ___ & ___ month gestation, BM becomes the primary site of hematopoiesis sources at birth: adult: bones: |
5th and 6th month at birth: BMadult: Sternumbones: Flat bones of sternum, ribs, vertebrae, skull, pelvis |
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chromatin pattern |
Most reliable indicator of maturity |
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Hypoxia |
Primary stimulus of erythropoiesis. |
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Retics stay in __ for ___ days and ___ day in ___ |
Retics stay in BM for 1-2 days and 1 day in PB |
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(3) Polychromatophilic Normoblast/Polychromatic Erythroblast |
Last stage capable of mitosis start of hgb synthesis Murky blue-gray to pink-gray |
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(4) Orthochromic Normoblast/Erythroblast/Metarubricyte |
small pyknotic nucleus Last nucleated stage |
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Direct Plt Determination Reese-Ecker: Guy & Leake: Brecker-Cronkite: Unopette |
RE: sodium citrate, formalin, brilliant cresyl blue GL: sodium oxalate, formalin, crystal violet BC: EDTA, 1% ammonium oxalate (to lyse rbcs); Phase contrast microscopy (IDEAL) Unopette: 1% ammonium oxalate |
UNOPETTE Diluent: 1.98mL Blood: 0.02mL TV: 2mL Dilution (1:100) |
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Indirect Plt Determination 1. 2. 3. |
Dameshek Fonio Olef |
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Imatinib mesylate |
Used to block tyrosine kinase signaling |
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