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28 Cards in this Set
- Front
- Back
role of alcohol & tobacco in head/neck cancers
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both are risk factors, together they are synergistic
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HPV status in head/neck
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improved outcomes in HPV positive
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surgery is the treatment of choice in all head/neck except
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laryngeal- chemo + rad is equivalent to surgery and no organ damage
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cetuximab + cisplatin effectiveness in head/neck
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improved OR, no benefit in PFS or OS
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cetuximab + RT effectiveness in head/neck
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cetuximab is radiosensitizer --> improved PFS & OS vs RT alone
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head/neck treatment of early stage disease
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surgery or RT
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head/neck treatment of locally advanced disease
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surgery, then RT or chemo +RT if unresectable
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std chemo induction regimen for head/neck
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DCF- docetaxel improves OS
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radiosensitizing chemo agents in head/neck
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*cisplatin, also: 5FU, cetuximab, carbo, MMC, bleo, and paclitaxel
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head/neck treatment for metastatic
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single agent equivalent to combination for OS. Cisplatin + 5FU has higher response rate than single agent
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metastatic head/neck use of cetuximab
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cetuximab + combined chemo has survival benefits over combined chemo alone
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most common cancers that metastisize to brain (2)
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breast & lung
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brain tumor more common in men & tumor more common in women
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men= gliomas
women= meningiomas |
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age glioblastomas occur
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age 15 and increase above age 45
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medulloblastoma and embryonal tumors rarely occur after age
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20 yrs
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intratumor chemical that predicts responsiveness to alkylating agents in CNS tumors
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MGMT: increased levels result in resistance.
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higher incidence of meningiomas in women with
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breast cancer
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chemo in meningioma
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no benefit w/chemo. Surgical resection is curable if completely resected. DVT rate up to 72% post-op
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most aggressive type of astrocytoma
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glioblastoma multiforme
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chemo is astrocytoma
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no role. Surgery if possible, or RT
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chemo role in anaplastic astrocytoma
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adjuvant chemo has benefit with cytoreductive surgery or RT
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chemo regimen in anaplastic astrocytoma
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carmustine 200mg/m2 Q6wk or procarbazine, CCNU, vincristine
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salvage treatment for anaplastic astrocytoma
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temozolamide 150mg/m2/d for 5 days in 1st cycle followed by 200mg/m2/d for subsequent cycles. Cycle =28 days
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addition of ___ to rad improves OS in GBM
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temozolomide
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temozolomide doses in GBM
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75mg/m2 QD during RT and 150-200mg/m2/d x 5 days every 28 days x 6 cycles
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add to temozolomide therapy with daily use + RT
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PCP prophylaxis (Septra DS)
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chemo for recurrent disease in GBM
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irinotecan + bevacizumab
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most active chemo agent in Primary Central Nervous System Lymphomas (PCNSL)
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HD-MTX 3.5-8 g/m2 Q14d
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