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44 Cards in this Set
- Front
- Back
This agent is a cofactor for activation of antithrombin. |
Heparin |
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Clinical use of heparin? |
Used for PE, ACS, MI, DVT, can be used during pregnancy |
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Used for PE, ACS, MI, DVT, can be used during pregnancy. |
Heparin |
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Argatrobam, bivalirudin clinical use? |
Inhibits thrombin, used for heparin-induced thrombocytopenia |
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Inhibits thrombin, used for heparin-induced thrombocytopenia |
Argatrobam, bivalirudin |
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Warfarin (coumadin) clinical use? |
Chronic anticoag.; STEMI, venous thromboembolism prophylaxis |
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Warfarin (coumadin) side effects? |
Bleeding, teratogenic, skin/tissue necrosis, drug-drug interactions |
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Name direct factor Xa inhibitors. |
Apixaban, rivaroxaban
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Apixaban, rivaroxaban are what type of agents? |
Direct factor Xa inhibitors. |
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Apixaban clinical use? |
Rx/prophylaxis of PE and DVT. |
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Rx/prophylaxis of PE and DVT. |
Apixaban, rivaroxaban |
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Examples of thrombolytics? |
Alteplase (tPA), tenecteplase (TNK-tPA) |
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Alteplase (tPA), tenecteplase (TNK-tPA), are examples of what type of agents? |
Thrombolytics |
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Alteplase clinical use? |
Early MI, early ischemic stroke, severe PE |
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Reteplase clinical use? |
Early MI, early ischemic stroke, severe PE |
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Examples of ADP receptor inhibitors? |
Clopidogrel, ticlopidine, prasugrel |
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Clopidogrel, ticlopidine, prasugrel are examples of what type of agents? |
ADP receptor inhibitors |
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ADP receptor inhibitors clinical usage? |
ACS; coronary stenting-decrease thrombotic stroke occurrences |
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Cilostazol, dipyridamole function? |
Inhibit phosphodiesterase III causing increase cAMP in platelets>inhibits platelet aggregation |
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Cilostazol, dipyridamole clinical use? |
Intermittent claudication, coronary vasodialtion, prevent stroke/TIAs, angina prophylaxis |
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Examples of GPIIb/IIIa inhibitors? |
Abciximab, eptifibatide, tirofiban |
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Clinical use of abciximab? S/E? |
Unstable angina. Bleeding, thrombocytopenia |
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Dactinomycin is used for? |
Wilms tumour, Ewing sarcoma, rhabdomyosarcoma, childhood tumours |
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Used forWilms tumour, Ewing sarcoma, rhabdomyosarcoma, childhood tumours. |
Dactinomycin |
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Doxorubicin clinical use? |
Solid tumours, leukaemias, lymphomas |
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Used forsolid tumours, leukaemias, lymphomas |
Doxorubicin |
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Bleomycin clinical use? |
Testicular cancer, Hodgkin lymphoma |
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Used fortesticular cancer, Hodgkin lymphoma |
Bleomycin |
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Clinical use of cyclophosphamide? |
Solid tumours, leukemia, lymphomas |
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Clinical use of nitrosureas? |
Brain tumours |
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Clinical use of Busulfan? |
CML, bone marrow ablation before transplant |
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Vincristine mechanism? |
Bind beta-tubulin; inhibits polymerization into microtubules causing M-phase arrest |
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Vincristine clinical use? |
Solid tumours, leukemias, lymphomas |
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Paclitaxel clinical use? S/Es? |
Ovarian and breast carcinomas. Myelosuppression, alopecia, HS |
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Cisplatin/carboplatin mechanism? Clinical use? |
Cross-link DNA. Testicular, bladder, ovary, and lung carcinomas |
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Etoposide mechanism and clinical use? |
Inhibits topoisomerase II>inc. DNA degradation. Solid tumours, leukemias, lymphomas |
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Irinotecon clinical use? S/Es? |
Colon cancer. Severe myelosuppression, diarrhea |
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Hyrdoxyurea clinical use? |
Melanoma, CML, sickle cell disease |
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Prednisone clinical use in oncology? |
CLL, non-hodgkins |
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What is tamoxifen? |
Selective estrogen receptor modulator; antagonist in breast and agonist in bone |
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What is rituximab? |
Monoclonal Ab against CD20 |
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Clinical use of vemurafenib? |
Metastatic melanoma |
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What is bevacizumab? |
Monoclonal antibody against VEGF; inhibits angiogenesis |
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Clinical use of bevacizumab? |
Solid tumours, ex. colorectal cancer, renal cell carcinoma |