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16 Cards in this Set
- Front
- Back
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T / F ? Glycolysis is a fasted state cytosolic process in all cells?
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False, it is a fed state cytosolic in all cells
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A few starting materials include?
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Glucose, NAD+, ADP(ATP)
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Products are ...
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pyruvate, NADH, ATP (ADP)
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Where does this occur?
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cytosol of all cells
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When does this occur?
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all cells in fed state, RBCs & brain in fasted state
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The process includes a few general "subprocesses"
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oxidation of carbons, reduction of NAD+ . NADH
production of ATP from ADP |
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What is the main regulated enzyme ?
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Phosphofructose kinase
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What do kinases do?
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add phosphate from ATP to molecules hydroxyl group
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Isomerases do?
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relocate functional groups w/in molecule to produce diff isomers
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Dehydrogenases ...
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catalyze diff oxidate/red rxns using nucleotide cofactors
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PFK is allosterically feedback inhibited/activated by AMP?
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Activated
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PFK is allosterically feedback inhibited/activated by ATP?
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Inhibited
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Why AMP - not ADP - that activates PFK?
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Myokinase (a cytosolic enzyme) is the specific enzyme that uses 2ADP <-> 1 ATP + 1 AMP. Being in cytosol this is faster than using ox.phos ETC process
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PFK has diff sites 2 bind ATP as substrate or inhibitor ... click for more info
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The active site binds ATP w much lower Km than inhibitor site
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NAD+ is reduced to NADH via whom?
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glyceraldehyde-3-phosphate dehydrogenase. NADH must be reoxidized for glyco to continue
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Kinase rxns are irreversible under biological conditions...
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true fact
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