Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
Does chemotherapy cross the placenta?
|
Yes
|
|
What are fetal risks for chemotherapy in pregnancy if given after the first trimester?
|
still birth
intra-uterine growth restriction fetal toxicities |
|
what are the most common cancers for women aged 20-44?
|
Breast cancer - 34%
Cervical Cancer - 10% Thyroid cancer- 9% |
|
what is the percentage of cancer in pregnancy?
|
0.02% - 0.1%
|
|
what is the definition of teratogenicity
|
the structural or functional dysgenesis of fetal organs
|
|
what is the baseline rate of congenital malformations?
|
1-3%
|
|
what the molecular weight through which molecules can pass through the placenta?
|
500 daltons
if >1000 daltons- then cannot pass |
|
what is the all -or-none period?
|
from conception to 8-14 days
an insult at this time leads to miscarriage or intact survival |
|
what is the most sensitive time for drug exposure?
|
2-8 weeks post-conceptin
esp. week 3-5 |
|
what impact can drugs have during the fetal phase?
|
Can lead to IUGR, low birth weight
|
|
What is the type of malformations that thalidomide use lead to?
|
Phocomelia - under-developed limbs and absent pelvic bones
CNS abnormality |
|
what is thalidomide and lenalidomide currently used for?
|
the treatment of multiple myeloma
|
|
Most fetuses with exposure to chemotherapy in the second trimester are born___________
|
healthy
|
|
what do the platinum chemotherapeutic agents do?
|
impairs DNA cross-linking
|
|
what do the taxanes and plant alkaloids do?
|
inhibit mitosis
|
|
In general chemotherapeutic agents in the 2nd trimester do not lead to specific harm? T or F
|
True
there were abnormalities, but not a specific collection |
|
When should you usually deliver women who have been on chemo?
|
usually want to wait 2-3 weeks until the myelosuppression improves
and fetal drug excretion from the placenta has occurred |
|
should you breast feed while on chemo?
|
NO
except with azathioprine |
|
what is another concern for women who get chemo while pregnant?
|
there is an increased risk for secondary malignancy in the children born to the mothers who got chemo
|