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25 Cards in this Set
- Front
- Back
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Neoplasms in the stomach
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AdenoCA
lymphoma leiomyoma |
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2 epithelial tumors of stomach
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polyps
adenoCA (90-95%) |
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3 types of non-epithelial tumors of stomach
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leiomyoma
lymphoma (4-5%) GI stromal tumors (2%) |
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Leiomyoma basics
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smooth muscule, benign tumor, well circumscribed
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Complications of leiomyomas
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ulceration, hemorrhage
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Where do gastric leiomyomas develop?
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below surface epithelium
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Definition of polyp.
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focal protrusion of mucosa into lumen
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When do non-neoplastic polyps occur?
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following injury
made of aggregates of mucosal and inflammatory cells |
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additional types of infiltrating gastric malignancies
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diffuse
linitis plastica |
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Differentiate between peptic ulcers and ulcerating malignancy.
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PUD: flat margins, vertical sides, smooth base
UM: heaped up margins, irregular sides, shaggy base |
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2 special lymph nodes for gastric malignancy
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L supraclavicular node (Virchow node)
periumbilical node |
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3 general places for gastric malignancies to metastasize
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lymph nodes
local invasion (peritoneal seeding) distant sites via hematogenous spread (ovary, Krukenberg tumor) |
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Pathogenesis of gastric adenoCA
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pre-existing dz, intestinal metaplasia, dysplasia, adenoCA
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2 ex of pre-existing dz of gastric adenoCA
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H.pylori
chronic atrophic gastritis |
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Tumor thickness along length of wall of stomach
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linitis plastica
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Path of intestinal type of gastric adenoCA
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chronic gastritis w/ intestinal metaplasia->dysplasia->adenoCA
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Path of diffuse type of gastric adenoCA
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arises from gastric mucous cells
see dis-cohesive mucous cells= single ring cells +desmoplasia |
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Growth of diffuse type of gastric adenoCA
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single cells, cell clustrs, or sheets
desmoplasia can lead to linitis plastica |
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What can both types of adenoCA make?
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lakes of extracellular mucus
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2 general differences with histopath of adenoCA
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early (mucosa/submucosa)
advanced (muscularis +/- serosa) |
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What makes up a majority of the diffuse type of adenoCA?
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desmoplasia
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significant prognostic features for gastric adenoCA
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depth of invasion
extent of nodal and distant metastases |
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What type of cx is MALT?
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low grade B cell lymphoma
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Pathogenesis for MALToma
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H.pylori infection, chronic inflammation expands MALT
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Histopath of gastric lymphoma MALToma
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small malignant lymphocytes infiltrate mucosa and destroy gastric glands
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