Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
H2 blockers (end in "tidine")
cimetidine ranitidine famtidine nizatidine |
- reversible block of H2 receptors leads to decreased H+ production by parietal cells
-used for peptic ulcer, gastritis, esophageal reflux -tox: cimetidine inhibits P450, and also has antiandrogenic effects (prolactin release, gynecomastia), it can also cross BBB to cause confusion, headaches, dizziness. can also cross placenta -both cimetidine and ranitidine decreased renal excretion of creatinine |
|
|
proton pump inhibitors
omeprazole lansoprazole |
- irreversibly inhibit H/K ATPase in parietal cells
-used for peptic ulcer, gastritis, reflux, zollinger ellision syndrome |
|
|
bismuth, sucralfate
|
- bind to ulcer base providing physical protection and allows HCO3 secretion to reestablish pH gradient in mucous layer
- used for ulcer healing, traveler's diarrhea |
|
|
triple therapy for H.pylori ulcers
|
amoxicillin
metronidazole (or tetracycline) bismuth also use PPI |
|
|
misoprostol
|
- a prostaglandin (PGE) analog
-increases secretion of mucous barrier and decreases acid production - used for prevention of NSAID induced peptic ulcer, maintenance of patent ductus arteriosus tox: diarrhea |
|
|
muscurinic antagonists
pirenzepine propantheline atropine |
- block M1 receptors on ECL cells thereby decreasing histamine production
-block M3 receptors on parietal cells therby decreasing H production -used for peptic ulcer tox: tachycardia, dry mouth, difficulty focusing eyes |
|
|
anatcids
aluminum OH magnesium OH calcium carbonate |
- AlOH- constipation, hypophosphatemia, proximal muscle weakness, seizures
- MgOH- diarrhea, hyporeflexia, hypotension, cardiac arrest - CaCO3- hypercalcemia, rebound acid increase |
|
|
infliximab
|
- monoclonal Ab to TNF. anti inflammatory
-used for Chron's disease, RA - tox: resp infection, fever, hypotension, reactivation of latent TB |
|
|
sulfasalazine
|
- a combo of sulfapyridine and mesalamine. activated by colonic bacteria
- used for ulcerative collitis, chrons - tox: malaise, nausea, oligospermia, bone marrow suppression |
|
|
ondansetron
|
- serotonin antagonist. powerful central acting anti-emetic
- control vomiting postop and in pts undergoing chemo - tox: headache, constipation |
|
|
metoclopramide
|
- D2 receptor antagonist. increase resting tone, contractility, LES tone, motility
- used for diabetic & post surgery gastroparesis - tox: increase parkinsonian like effects, restlessness, nausea, diarrhea. DRUG INTERACTION WITH DIGOXIN & DIABETIC AGENTS. contraindicated in patients with small bowel obstruction |
