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33 Cards in this Set
- Front
- Back
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CTZ has what receptors
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D2
5-HT H1 Opiod - Mu NK-1 (neurokinin) M1 (muscarinic) |
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Vestibular vomiting center has what receptors
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H1
M1 |
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Acepromazine as GI drug
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Primarily a phenothiazine - dopamine antagonist but also acts at H1
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Phenothiazine
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Acepromazine
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Antiserotonin as GI drug
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Blocks 5HT 3 (antagonist)
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5HT3 antagonist
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Ondansetron
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Ondansetron
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5HT antagonist
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Moropitant
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NK-1 antagonist
Approved for dogs acts centrally/peripherally Substance P inhibitor |
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NK-1 receptor blocker
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Moropitant
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Metaclopramide
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D2 antagonist, but also prokinetic
5HT-3 antagonist - vomiting 5HT-4 agonist |
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Drugs that increase GI motility
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Metoclopramide
Cisapride Bethanechol Lidocaine Domperidone |
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Metoclopramide as prokinetic
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Increases Ach release to increase smooth muscle contraction
early GI tract |
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Bethanecol
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Cholinergic agonist
Entire GI works elsewhere in body with many effects |
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Cisapride
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5HT 4 agonist
5HT3 antagonist |
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Domperidone
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Dopamine antagonist
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Lidocaine
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Na channel blocker
unknown MOA |
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Acid suppressant drugs
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H2 blockers
Cimetidine < Ranitidine < Famotidine |
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Proton pump inhibitors
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Omeprazole
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Omeprazole
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Proton pump inhibitor
continues working after blood levels have declined |
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Magnesium hydroxide
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neutralizes acidic pH
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Protective GI drugs
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Misoprosotol
Sucralfate |
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PGE-1 analogue
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Misoprosotol
Used with chronic NSAID use ADE: abortion |
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Sucralfate
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attaches to stomach
Need acidic environment to work so give before H2 suppressant |
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Cimetidine side effect
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inhibits cytP450
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Cimetidine and Misoprotol don't _______ just _____.
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treat ulcer
prevent it |
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Decreases GImotility
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Antimuscarinics
Atropine Glycopyrolate |
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Anti-diarrheal drugs
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Mu receptor
Opioid Loperamide Diphenoxylate |
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Diphenoxylate
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mu receptor agonist
Can cross to CNS, |
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Diphenoxylate also has _______ to _____
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atropine
prevent abuse |
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Loperamide and Dipehnoxylate MOA
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decreases motility
increases digestion Must also treat viral/baterial problems |
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Loperamide is also called
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immodium
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Diphenoxylate
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Lomatil
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If you give too much atropine, glyco, or N-butyl what can you do
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Bethanechol
But be aware of heart effects as well |
