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10 Cards in this Set
- Front
- Back
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function of GPs
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sugar is activation site
affects protein folding protein targeting (carb = address) blood groups cancer renal filtration coagulation |
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characteristic of glycoprotein
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protein w/sugar attached
via covalent bond N linked or O linked glycosylation sugar added at rough ER |
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location of glycosylation for glycoproteins
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rough ER forms
-n acetylglucosamine, mannose & glucose processed in golgi -remove mannose -may add gal or NANA (sialic acid) high mannose becomes complex |
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N linked glycoprotein
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asparagine
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O linked glycoprotein
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serine to galactosine
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protein folding
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calnexin & calreticulin are chaperones
glucosidase -allows ok prot to be secreted UDP glucose -returns for refold Ubiquitin -to proteosome for destruction |
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tissue targeting
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leukocyte surveillence
-p selectin -sialyl lewis X activates fucosyl transferase high endothelial venules -addressins lysosmal targeting -neuraminidase- prevents degredation of GPs |
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blood groups
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B has N galactose
A has N acetylgalactosamine O has neither AB has both |
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proteoglycans function
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renal filtration
coagulation- hep sulfate & thrombin /AT co receptor- VEGF lipoprotein lipase -hep sulfate holds near endothel, (allows viral entrance) hepatocytes- chylo remnants held near hepatic lipase |
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renal filtration
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podocalyxin- charge repulsion
argin, perlecan & collagen- selective size |
