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13 Cards in this Set
- Front
- Back
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Pharmacogenomics is the study of genetic contribution to response to drugs, both in terms of ___________ and ______________ |
drug efficacy; adverse drug effects |
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What is PGP |
Drug transporter proteins. Transports drugs out of cell. |
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Is metabolism part of pharmacodynamics or pharmacokinetics? |
Kinetics |
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What is the enzyme that metabolizes mercaptopurine? |
TPMT |
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Primary metabolizing enzyme for warfarin |
2C9 |
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Is 2C9 involved in pharmacodynamics or pharmacokinetics? |
Pharmacokinetics |
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What enzyme is associated with the drug target for warfarin? |
VKOR |
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Is VKOR associated with pharmacokinetics or pharmacodynamics? |
Pharmacodynamics |
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People with a *3 polymorphism of CYP2C9 have a _____% reduced warfarin metabolism |
90% |
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People with a 2*3* genotype for CYP2C9 are _________ metabolizers of warfarin, while people with a 1*2* genotype are _________ metabolizers. |
Poor; good |
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What is associated with the warfarin drug target |
VKORC1 |
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VKOR variation accounts for _____% of variation in warfarin response |
20-25 |
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Someone with an AA genotype for their VKOR gene is ________ sensitive to warfarin |
more |
