Fungal Infections

Front 1

Fungi are what kind of organisms?

Back 1

Eukaryotic

Front 2

Generally fungi hit which group of patients?

Back 2

The immunocompromised

Front 3

Dermatophytosis causes infections where and is caused by which group of fungi?

Back 3

Hair

Skin

Nails

Dermatophytes or ringworm fungi

Front 4

Give examples of dermatophytosis?

Back 4

Tinea pedis

Tinea capitis

Tinea corporis

Front 5

Name the three genera of dermatophytes?

Back 5

Trichophyton

Microsporum

Epidermophyton

Front 6

Which dermatophytoses are most common and by which causative organisms?

Back 6

Foot and nail infections

by:

T.interdigitale

T.rubrum

Front 7

Dermatophytosis responds to what treatment?

Back 7

Topical therapy

Scalp or nail infections require oral therapy

Front 8

Traumatic implantation of fungal spores results in what?

Back 8

Subcutaneous mycoses

Front 9

What is mycetoma?

Back 9

A chronic, subcutaneous, localised destructive infection of the skin to the bone on the hands and feet

Front 10

Where is subcutaneous mycoses most common in terms of world region?

Back 10

Tropical or sub-tropical climates

Front 11

What treatment may be indicated?

Back 11

Amputation

Front 12

Which subcutaneous mycosis spreads via the lymph?

Back 12

Sporotrichosis caused by S.schenckii

See nodules and ulceration along the lymphatics

Front 13

Candida are commensals where in 30-50%?

Back 13

Mouth and GI tract

Front 14

Most common areas of candida infection?

Back 14

Mucosal (thrush)

Cutaneous

Nail

Front 15

Candidosis causes deep seated infection in which group of patients?

Back 15

Immunocompromised (>80% of AIDS patients get oral candidosis)

Front 16

Other than AIDS sufferers who is oral candidosis most common in?

Back 16

The extremes of age

Front 17

Name two pre-disposing factors for infection by candida other than being immunocompromised?

Back 17

Diabetes mellitus

Antibiotic therapy

Front 18

Deep seated candidosis is common in neutropenic patients and is best treated how?

Back 18

Fluconazole and/or amphotericin

Front 19

Cryptococcus is caused by which fungi?

Back 19

Cryptococcus neoformans

Front 20

Comes from which source?

Back 20

Soil and old bird droppings

Front 21

Infected how with cryptococcus?

Back 21

Inhalation

Front 22

Most common presentation of cryptococcus?

Back 22

Cryptococcal meningitis

Front 23

How is cryptococcus diagnosed?

Back 23

Via cryptococcal antigen

Front 24

Rx for cryptococcus?

Back 24

Amphotericin B and flucytosine

Front 25

Aspergillosis caused by

Back 25

Aspergillus and A.fumigatus

Front 26

Mode of infection with aspergillus?

Back 26

Inhalation

Front 27

What may occur in patients residual lung cavities?

Back 27

Fungus ball

Front 28

What can occur with aspergillus in the immunocompromised?

Back 28

Dissemination to other organs

Front 29

Mortality associated with invasive aspergillosis?

Back 29

90%

Front 30

Treatment of choice for aspergillosis?

Back 30

Voriconazole if invasive

Itraconazole for prophylaxis against invasion

Front 31

Zygomycosis is caused by what?

Back 31

Thermophilic fungi such as Rhizopus, Lichtheimia and Mucor

Cutaneous infection of wounds

Front 32

Zygomycosis occurs in which group of patients?

Back 32

Diabetes mellitus uncontrolled and Neutropenia

Front 33

It is rapidly progressing and what is usually the only method of treatment for zygomycosis?

Back 33

Amputation

Front 34

Treatment for zygomycosis?

Back 34

Aggressive lipid therapy with amphotericin and posaconazole