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19 Cards in this Set
- Front
- Back
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What are the 2 categories of Indirect-Acting Antiadrenergic Agents?
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1. Adrenergic Neuron-Blocking Agents 2. Centrally Acting Alpha2 Agonists
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Which group acts within the CNS to reduce the outflow of impulses along sympathetic neurons?
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Centrally Acting Alpha2 Agonists
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Adrenergic Neuron-Blocking agents act in the terminals of sympathetic neurons and decrease the release of _________.
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Norepinephrine
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Reserpine is an andregergic neuron-blocking agent and its primarily indicated to treat ________. Its main side effect is ________.
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Hypertension, Depression
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Reserpine is classified as an "Rauwolfia Alkaloid" b/c it comes from the root of a shrub (Rauwolfia serpentina) indigenous to what country?
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India
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Reserpine stimulates Alpha receptors in the CNS to inhibit vasoconstriction, thereby ______ peripheral resistance and ______ blood pressure.
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Reducing, Reducing
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How long does it take for Reserpine's antihypertensive response to develop?
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1 week
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An abrupt stop to a Reserpine regiment could result in _____ _____.
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Rebound Hypertension
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In what 2 ways does Reserpine deplete norepinephrine?
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1. It acts on vesicles in nerve terminal and displaces stored NE, exposing it to destructive monoamine oxidase. 2. It blocks uptake of dopamine (the precursor to NE) into presynaptic vesicles.
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A common side effect of Reserpine is
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Edema, resulting from sodium and water retention
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Common adverse effects of Reserpine include
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Depression, bradycardia, orthostatic hypotention, nasal congestion, GI problems
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Guanadrel and Guanethidine are also adrenergic neuron-blocking agents but, unlike Reserpine, cannot cross the BB barrier and therefore don't cause adverse effects in the ______
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CNS
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Clonidine and Methyldopa are examples of ____ ____ ____ ____
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centrally acting alpha2 agonists
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Clonidine and Methyldopa treat hypertension by _____ the firing of sympathetic neurons.
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Reducing
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Clonidine causes "selective" activation of alpha2 receptors in the CNS that are associated with autonomic control of the _________ system.
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Cardiovascular
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Because Clonidine is lipid-soluble, it is ______ absorbed after oral administration.
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Quickly: hypotensive response occurs within 1 hour and peaks at 4 hours
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Clonidine is used to treat hypertension but also sever pain associated with _____
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Cancer
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Hemolytic Anemia and hepatic necrosis (liver damage) are two side effects to what drug?
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Methyldopa
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A _____ test detects the presence of antibodies that cause hemolysis which leads to hemolytic anemia.
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Coombs'
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