Folinic Acid

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Folinic acid

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leucovorin

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administered as calcium or sodium folinate

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is an adjuvant used in cancer chemotherapy involving the drug methotrexate

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may also be useful in the treatment of acute methotrexate overdose

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also used in synergistic combination with the chemotherapy agent 5-fluorouracil in colon cancer

it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase

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folinic acid is a vitamer for folic acid (B9 ), and has the full vitamin activity of this vitamin

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contraindications

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pregnancy

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it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. This is the classical view of Folinic acid rescue therapy.