Fm1 Exam I Pharm Drugs

Front 1

what is the mechanism of action for all steroids (for now)

Back 1

nuclear receptors that regulate gene expression
antiinflammatory inhibits COX2
decreases cytokines
decreased endogenous mediators of inflammation
apoptosis of eosinophils

Front 2

cortizone 10

Back 2

hydrocortisone

Front 3

prednisone

Back 3

sterapred

Front 4

cultivate, flovent

Back 4

fluticasone

Front 5

betamethasone

Back 5

cerestone

Front 6

name five steroid drugs

Back 6

betamethasone
dexamethasone
prednisone
hydrocortison
fluticasone

Front 7

what do u use hydrocortisone for

Back 7

asthma

Front 8

what is salmeterol

Back 8

advair
formulation of fluticasone

Front 9

TX using hydrocortisone

Back 9

anaphylaxis, ashtma, COPD, IBD, rheumatic disorders, dermatoses, replacement

Front 10

TX using prednisone

Back 10

autoimmune
allograft refjection
asthma
IBD
RA

Front 11

uses of fluticasone

Back 11

dermatoses
allergic and non allergic rhinitis

Front 12

can you use fluticasone for dermatoses?

Back 12

yes

Front 13

which steroids work for IBD and RA?

Back 13

hydrocortisone
prednisone

Front 14

what are side effects common to all steroids we know

Back 14

cataracts
glaucoma
opportunitstic or pre existing infections

Front 15

which steroid uses cyp3A4

Back 15

fluticasone and prednisone

Front 16

list the side effects of prednisone

Back 16

CNS: headaches, insomnia, vertigo, depression, anxiety, personality chagnes, psychosis
GI: NVD, anorexia, gastritis, cataracts

Front 17

what is special about prednisone metabolism

Back 17

must be metabolized by 3A4 to active metabolite prednisolone

Front 18

what are the indications for NSAIDs

Back 18

analgesia
antipyretic
inflammatory pain

Front 19

how do NSAIDS work

Back 19

inhibit COX to decreas PG and TXA

Front 20

what are the effects of PG and TXA that NSAIDS hope to block

Back 20

pain
platelet aggregation

Front 21

what is asiprin an example of?

Back 21

ion trapping
aero order kinetics

Front 22

whta are side effects of NSAIDs in nearly 40% of pts

Back 22

nausea
heartburn
dyspepsia
abdominal pain

Front 23

what increases risks of side effects of NSAIDS

Back 23

age
GI history
antigoagulatnts
SSRIs

Front 24

what two diseases are associated with aspirin

Back 24

reyes
hypersensitivy

Front 25

which NSAID is irreversible? what are the rest?

Back 25

aspirin
reversible inhibitors

Front 26

T or F. all nsaids may be given orally

Back 26

true

Front 27

what NSAIDS are avail OTC

Back 27

ketoprofen
ibuprofen
aspirin
naproxen

Front 28

what is the only NSAID not implcated for serious CV risks?

Back 28

naproxen

Front 29

what is the most prescribe NSAID in the world

Back 29

diclofenac

Front 30

what are indications for diclofenac

Back 30

osteoarthritis pain

Front 31

what is sprix

Back 31

ketorolac nasal formulation

Front 32

what NSAIDS do you need to know

Back 32

aspirin
nonacetylated salicylates
ibuprofen
keotprofen
naproxen
diclofenac
ketorolac
celecoxib

Front 33

which NSAID is selective inhibitor of COX2 only

Back 33

celecoxib

Front 34

which NSAID could you Rx pre-op

Back 34

celecoxib

Front 35

what is a risk of celecoxib

Back 35

stevens johnson

Front 36

which COX do platelets have

Back 36

COX1 so selective COX2 will have no effect

Front 37

alprostadil =

Back 37

caverject

Front 38

what prostanoids do you need to know

Back 38

alprostadil
latanoprost
midoprostol

Front 39

what are indicatios for alprostadil

Back 39

ED or surgery needed in neonates

Front 40

what is alprostadil a syntehtic of?

Back 40

PGE1 agonist at EP

Front 41

T or F. all the prostanoid we talked about are antagonists.

Back 41

FALSE agonist

Front 42

what do you tx glaucoma with

Back 42

latanoprost

Front 43

latanoprost -

Back 43

xalatan

Front 44

what receptor works in latanoprost

Back 44

FP

Front 45

what are indications for misoprostol

Back 45

stomach ulcers
unwanted pregnancy

Front 46

what do you follow mifepristone with

Back 46

misoprostol for early PG termination

Front 47

what preg X risk drug do you know

Back 47

misoprostol

Front 48

what are indications for zileuton

Back 48

asthma

Front 49

how does zileuton work

Back 49

5LOX inhibitor

Front 50

what metabolizes zileuton

Back 50

1A2
2C9
3A4

Front 51

what do you need to monitor with zileuton

Back 51

LFTS every 2-3 months

Front 52

T or F. all the leukotriene agents are protein bound

Back 52

true

Front 53

what is the difference between zafirlukas and montelukast

Back 53

feces
bile

Front 54

what are indications for montelukast and zafirlukast

Back 54

asthma
allergic rhinitis

Front 55

what metabolizes both zafirlukast and montelukast

Back 55

3A4
2C9

Front 56

add ______ if you have to prescribe celecoxib for extended periods or to persons with increased risk of thrombotic events

Back 56

low dose aspirin

Front 57

avoid ____ to benefit from the protective effect of celecoxib on the gut

Back 57

aspirin

Front 58

____ intereferes with the cadioprotectic effect of low dose aspirin

Back 58

ibuprofen

Front 59

what leuko agents do you need to know

Back 59

montelukast
zafirlukast
zileuton

Front 60

singulair =

Back 60

montelukast

Front 61

accolade =

Back 61

zafirlukast

Front 62

zyflow =

Back 62

zileuton