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91 Cards in this Set

  • Front
  • Back
Anticentromere antibodies
Scleroderma (CREST)
Antidesmoglein (epithelial) antibodies
Pemphigus vulgaris (blistering)
Anti-glomerular basement membrane antibodies
Goodpasture's syndrome (glomerulonephritis and lung hemorrhage)
Antihistone antibodies
DRUG-induced SLE
Anti-IgG antibodies
Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity)
Antimitochondrial antibodies (AMAs)
1° biliary cirrhosis (female, cholestasis, portal HTN)
Antineutrophil cytoplasmic antibodies (ANCAs)
Vasculitis (Wegener's, microscopic polyangiitis, glomerulonephritis)
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
SLE (type III hypersensitivity)
Antiplatelet antibodies
Idiopathic thrombocytopenia purpura (ITP) (bleeding diathesis)
Anti-topoisomerase antibodies
Diffuse systemic scleroderma
Anti-transglutaminase/antigliadin antibodies
Celiac disease (diarrhea, distension, weight loss)
Azurophilic granular needles in leukemic blasts
Auer rods (Acute myelogenous leukemia: especially the promyelocytic type)
"Bamboo spine" on x-rays
Anklosing spondylitis (chronic inflammatory arthritis: HLA-B27)
Basophilic nuclear remnants in RBCs
Lead poisoning or sideroblastic anemia
Bloody tap on LP
Subarachnoid hemorrhage
"Boot-shaped" heart on X-ray
Tetralogy of Fallot, RVH
Branching gram-positive rods with sulfur granules
Actinomyces israelii
Bronchogenic apical lung tumor
Pancoast's tumor (can compress sympathetic ganglion and cause Horner's syndrome)
"Brown" tumor of bone
Hemorrhage (hemosiderin) causes brown color of osteolytic cysts. Due to:
1. Hyperparathyroidism
2. Osteitis fibrosa cystica (von Recklinghausen's disease of bone)
Cardiomegaly with apical atrophy
Chagas' disease (Trypanosoma cruzi)
Cellular crescents in Bowman's capsule
Rapidly progressive crsecentic glomerulonephritis
"Chocolate cyst" of ovary
Endometriosis (frequently involves both ovaries)
Circular grouping of dark tumor cell surrounding pale neurofibrils
Homer Wright rosettes (neuroblastoma, medulloblastoma, retinoblastoma)
Colonies of mucoid Psuedomonas in lungs
Cystic fibrosis (CFTR mutation in Caucasians resulting in fat-soluble vitamin deficiency and mucous plugs)
Degeneration of dorsal column nerves
Tabes dorsalis (3° syphilius)
Depigmentation of neurons in substania nigra
Parkinson's disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)
Desquamated epithelium casts in sputum
Curschmann's spiral (bronchial asthma; can result in whorled mucous plugs)
Disarrayed granulosa cells in eosinophilic fluid
Call-Exner bodies (granulosa-theca cell tumor of the ovary)
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia
Koilocytes (HPV: predisposes to cervical cancer)
Enlarged cells with intranuclear inclusion bodies
"Owl's eye" appearance of CMV
Enlarged thyroid cells with ground glass nuclei
"Orphan Annie" eye nuclei (papillary carcinoma of the thyroid)
Eosinophillic cytoplasmic inclusion in liver cell
Mallory bodies (alcoholic liver disease)
Eosinophilic cytoplasmic inclusion in nerve cell
Lewy body (Parkinson's disease)
Eosinophilic globule in liver
Councilman body (toxic or viral hepatitis, often yellow fever)
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Rabies virus (Lyssavirus)
Extracellular amyloid deposition in gray matter of brain
Senile plaques (Alzheimer's disease)
Giant B cells with bilobed nuclei with prominent inclusions ("owl's eye")
Reed-Sternberg cells (Hodgkin's lymphoma)
Glomerulus-like structure surronding vessel in germ cells
Schiller-Duval bodies (yolk sac tumor)
"Hair-on-end" (crew-cut) appearance on x-ray
β-thalassemia, sickle cell anemia (extramedullary hematopoiesis)
hCG elevated
Choriocarcinoma, hydatidiform mole (occurs with and without embryo)
Heart nodules (inflammatory)
Aschoff bodies (rheumatic fever)
Heterophile antibodies
Infectious mononucleosis (EBV)
Hexagonal, double-pointed, needle-like crystals in broncial secretions
Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)
High levels of D-Dimers
DVT, PE, DIC
"Honeycomb lung" on x-ray
Interstitial fibrosis
Hypersegment neutrophils
Megaloblastic anemia (B12, folate deficiency)
Hypochromin, microcytic anemia
Iron deficiency anemia, lead poisoning, thalassemia (HbF sometimes present)
Increased α-fetoprotein in amniotic fluid/maternal serum
Anencephaly, spina bifida (neural tube defect)
Increased uric acid levels
Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics
Intranuclear eosinophilic droplet-like bodies
Cowdry type A bodies (HSV or yellow fever)
Iron-containing nodules in alveolar septum
Ferruginous bodies (asbestosis: ↑chance of mesothelioma
Large lysosomal vesicle in phagocytes, immunocompromised
Chediak-Higashi disease (failure of phagolysosome formation)
Low serum ceruloplasmin
Wilson disease (hepatolenticular degeneration)
"Lumpy-bumpy" appearance on glomeruli on immunofluorescence
Poststreptococcal glomerulonephritis
Lytic ("hole-punched") bone lesions on x-ray
Multiple myeloma
Mammary gland ("blue-domed") cyst
Fibrocystic change of the breast
Monoclonal antibody spike
1. Multiple myeloma (called the M protein; usually IgG or IgA
2. Monoclonal gammopathy of undetermined significance (MGUS)
3. Waldenstrom's (M protein =IgM) macroglobulinemia
Monoclonal globulin protein in blood/urine
Bence Jones protein (multiple myeloma [kappa or lambda Ig light chains in urine]), Waldenstrom's (macroglobulinemia (IgM)
Mucin-filled cell with peripheral nucleus
Signet ring (gastric carcinoma)
Narrowing of bowel lumen on barium radiograph
"String-sign" (Crohn's disease)
Needle-shaped, negatively bifringent crystals
Gout (hyperuricemia)
Nodular hyaline deposits in glomeruli
Kimmelstiel-Wilson nodules (diabetic nephropathy)
"Nutmeg" appearance of liver
Chronic passive congestion of liver due to right heart failure
"Onion-skin" periosteal reaction
Ewing's sarcoma (malignant round-cell tumor)
Periosteum raised from bone, creating triangular area
Codman's triangle on x-ray (osterosarcoma, Ewing's sarcoma, pyogenic osteomyelitis)
Podocyte fusion on EM
Minimal change disease (child with nephrotic syndrome)
Polished, "ivory-like" appearance of bone at cartilage erosion
Eburnation (osteoarthritis resulting in bony sclerosis)
Protein aggregates in neurons from hyperphosphorylation of protein tau
Neurofibrillary tangles (Alzheimer's dosease and CJD)
Pseudopalisade tumor cell arrangement
Glioblastoma multiforme
RBC casts in urine
Acute glomerulonephritis
Rectangular, crystal-like inclusions in Leydig cells
Reinke crystals (Leydig cell tumor)
Renal epithelial casts in urine
Acute toxic/viral nephrosis
Rhomboid crystals, positively birefringent
Pseudogout (calcium pyrophosphate dihydrate)
Rib notching
Coarctation of the aorta
Sheets of medium-sized lymphoid cells ("starry sky" appearance on histology)
Burkitt's lymphoma (t[8:14] c-myc activation, associated with EBV)
Silver-staining spherical aggregation of tau proteins in neurons
Pick bodies (Pick's disease: progressive dementia. Similar to Alzheimer's)
Small granulomatous lesion in lungs (can calcify)
Ghon focus (1° TB: Mycobacterium bacilli)
Small, round RBC inclusions
Heinz bodies (G6PD deficiency, α-thalassemia, chronic liver disease
"Soap bubble" on X-ray
Giant cell tumor of bone (generally benign)
"Spikes" on basement membrane, "dome-like" endothelial deposits
Membranous glomerulonephritis (may progress to nephrotic syndrome)
Stacks of RBC
Rouleaux formation (high ESR: multiple myeloma)
Stippled vaginal epithelial cells
"Clue cells" (Gardnerella vaginalis)
"Tennis-racket" shaped cytoplasmic organelles (EM) in Langerhans cells
Birbeck granules (histiocytosis X: eosinophilic granuloma)
Thrombi made of white-red layers
Lines of Zahn (arterial thrombus, layers of platelets/RBCs)
"Thumb sign" on lateral x-ray
Epiglottitis (Haemophilus influenzae)
Thyroid-like appearance of kidney
Chronic bacteria pyelonephritis
"Tram-tracks" appearance on LM
Membranoproliferative glomerulonephritis
Triglyceride accumulation in liver cell vacuoles
Fatty liver disease (alcoholic or metabolic syndrome)
WBCs that look "smudged"
CLL (almost always B cell; affects the elderly)
"Wire loop" glomerular appearance on LM
Lupus nephropathy
Yellow CSF
Xanthochromia (subarachnoid hemorrhage)