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37 Cards in this Set
- Front
- Back
MOA of action of penicillin and cephalosporins
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inhibit cell wall synthesis by inhibition of peptidoglycan cross-linking
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Bacitracin and Vancomycin MOA
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block peptidoglycan synthesis
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What drugs block nucldeotide synthesis
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Sulfonamides, Trimethoprim
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MOA of fluroquinilones
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DNA topisomerase inhibitor
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MOA of Rifampin
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inhibits mRNA synthesis
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MOA of metronidazole
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Damages DNA
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50s ribosomal protein inhibitors
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Chloramphenicol
Linezolid Erythromycin (macrolides) streptogramins(quinupristin) |
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Penicillin MOA, Use and ADRs
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blocks transpeptidase cross linking of peptidoglycan
gram positives (strep pneumo and pyogenes, syphilis, actinomyces) ADRs- hemolytic anemia, hypersensitivity |
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Why is nafcillin penicillinase resistant
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bulkier R group
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MOA of action of penicillin and cephalosporins
|
inhibit cell wall synthesis by inhibition of peptidoglycan cross-linking
|
|
Bacitracin and Vancomycin MOA
|
block peptidoglycan synthesis
|
|
What drugs block nucldeotide synthesis
|
Sulfonamides, Trimethoprim
|
|
MOA of fluroquinilones
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DNA topisomerase inhibitor
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MOA of Rifampin
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inhibits mRNA synthesis
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MOA of metronidazole
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Damages DNA
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50s ribosomal protein inhibitors
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Chloramphenicol
Linezolid Erythromycin (macrolides) streptogramins(quinupristin) |
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30s ribosomal protein synthesis inhibitors
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Tetracyclines, Aminoglycosides
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Penicillin MOA, Use and ADRs
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blocks transpeptidase cross linking of peptidoglycan
gram positives (strep pneumo and pyogenes, syphilis, actinomyces) ADRs- hemolytic anemia, hypersensitivity |
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Why is nafcillin penicillinase resistant
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bulkier R group
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Main use for methicillin and nafcillin
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Staph
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ADRs for methicillin
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interstitial nephritis
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Clinical Use of Ampicillin/amoxicillin
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HELPSS
H. influ E. Coli Listeria Proteus Salmonella Shigella HELPSS kill enterococci |
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What is use for ticarcillin, carbenicillin, piperacillin
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pseudomonas
TCP- takes care of pseudomonas |
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What can you add to penicillins to make more resistant to penicillinase
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CAST
Clavinulic Acid Azobactam Tazobactam |
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ADRs for ampicillin
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ampicillin rash
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What organisms are not covered by cephalosporins
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Listeria, Atypicals (Chlamydia, Mycoplasma) MRSA, Entercocci
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1st Generation cephalosporins
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cefazolin
cephalexin |
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2nd Generation cephalosporins
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Cefoxitin
Cefuroxine Cefaclor |
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3rd generation cephalosporins
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Ceftriaxone
cefotaxime ceftazidime |
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4th generation cephalosporins
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Cefepime
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What is Cefepime used for?
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increased activity against pseudomonas and gram-positive organisms
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What is Ceftazidime used for?
Ceftriaxone? |
Pseudomonas
Ceftriaxone-meningitis and gonorrhea both are 3rd gen |
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Use for 2nd gen cephalosporins
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H. influe
Enterbacter aerogenes Neisseria Proteus mirabilis E. Coli Klebsiella Serratia |
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Use for 1st Gen Cephalosporins
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Proteus mirabilis
E. Coli Klebsiella |
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Toxicities with cephalosporins
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nephrotoxicty esp with aminoglycosides
vitamin K defiency disulfram reactions (cefamandole) |
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Monobactam MOA, use, toxicities (Aztreonam)
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binds to PB3, resistnat to beta lactames, disrupts cell wall synthesis
Use: gram negative rods only Useful in PENICILLIN ALLERGY PATIETNS, or those with renal failure or cannot take AMGS |
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Carbapenems
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(impinem, meropenem)
impinem always given with cilastatin(inhibits renal dehydropeptidase I) Use: life threatening gram positve cocci or gram negative rods CNS toxicity, GI distress |