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13 Cards in this Set
- Front
- Back
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Secreted by:
-Macrophages -all T-cells -Th1 -Th2 |
Secreted by:
-Macrophages **IL-1 **IL-6 **IL-8 **IL-12 **TNF-alpha -all T-cells **IL-3 -Th1 **IL-2 **IFN-gamma -Th2 **IL-4 **IL-5 **IL-6 **IL-10 ***HOT T-Bone stEAk (IL-1 fever, 2 Tcells, 3 bone marrow, 4 IgE, 5 IgA) ***clean up on aIsLe 8 (IL-8 recruits neutrophils to clear infections) |
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IL-1
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IL-1
Secreted by: **Macrophages Effects: **endogenous pyogen - fever, inflammation **activate endothelium express adhesion molecules **induce chemokine secretion recruiting leukocytes |
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IL-6
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IL-6
Secreted by: **macrophages **also Th cells Effects: **fever & stimulates acute-phase prtns **endogenous pyogen |
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IL-8
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IL-8
Secreted by: **macrophages Effects: **major chemotactic factor for neutrophils |
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IL-12
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IL-12
Secreted by: **macrophages **B-cells Effects: **differentiation Tcell --> Th1 **activates NK cell |
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TNF-alpha
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TNF-alpha
Secreted by: **macrophages Effects: **mediates septic shock **activates endothelium **leukocyte recruitment, vascular leak |
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IL-3
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IL-3
Secreted by: **all T-cells Effects: **like GM-CSF **supports growth & differentiation of bone marrow stem cells |
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IL-2
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IL-2
Secreted by: **Th1 cells Effects: **stimulate growth of helper & cytotoxic T-cells |
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IFN-gamma
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IFN-gamma
Secreted by: **Th1 **NK cells Effects: **activate macrophages **activate Th1 **inhibit Th2 **increase MHC I & II expression **increase antigen presentation in all cells |
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IL-4
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IL-4
Secreted by: **Th2 Effects: **differentiation Th --> Th2 **promote B-cell growth **enhance class switching to IgE & IgG |
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IL-5
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IL-5
Secreted by: **Th2 Effects: **differentiation of B-cells **enhance class switching to IgA **stimulate growth & diff of eosinophils |
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IL-10
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IL-10
Secreted by: **Th2 **Tregulatory Effects: **modulate inflammatory response **inhibit activated Tcells & Th1 **activate Th2 ***TGF-beta has similar actions to IL-10 --> inhibiting inflammation |
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IFN-alpha & beta
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IFN-alpha & beta
Secreted by: **wide range of eukaryotic cells Effects: **inhibit viral protein synthesis |
