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63 Cards in this Set
- Front
- Back
>???
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neutrophil (normal)
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What disease or condition?
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b12 or folate (hypersegmented neutrophil)
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what CD is necessary for t-cell activation?
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CD28 (costimulatory signal)
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hemophilia A deficiency
HEMOPHILIA B |
factor 8- A
factor 9- B |
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antithrombin inhibits what
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thrombin and factors 7a, 9a, 10a, 11a, 12a
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what are the microcytic anemias
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IDA
ACD(progresses from normocytic) Thalassemais Lead poisoning Sideroblastic |
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what is plummer-vinson syndrome triad?
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IDA, esophageal web, and atrophic glossitis
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alpha thalassemia present in what populations normally
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asian or african
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Hb barts gamma 4 is also known as
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hydrops fetalis
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what condition or disease
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liver disease, abetalipoproteinemia
acanthocytes |
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What disorder(s)
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thalassemias, anemia of chronic disease, Lead poisoning!
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What disorder or disease?
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G6PD def
bite cells |
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What disorder or disease
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DIC, TTP/HUS, traumatic hemolysis
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What disorder or diseases
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HbC disease, Asplenia, Liver disease, Thalassemia
target cells |
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What disorder or disease
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howell jolly bodies
functional hyposplenia, or asplenia |
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treatment for Pb poisoning in kids
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succimer
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Lead poisoning: what does lead inhibit?
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ferrocheletase and ALA dehydratase
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treatment for sideroblastic anemia
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pyridoxine b6
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defect in sideroblastic anemia
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gamma aminolevulinic acid synthase gene
x-linked |
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methylmalonic acid levels in b12 vs folate deficiency
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normal in folate deficiency...increased in b12
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decreased levels of what in g6pd deficiency
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glutathione (x-linked)
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labs for paroxysmal nocturnal hemoglobinuria
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increased urine hemosiderin
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tx for sickle cell anemia
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hydroxyurea, and BM transplantation
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hereditary spherocytosis tx
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splenectomy
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macroangiopathic hemolytic anemia causes
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prosthetic heart valves and aoritc stenosis
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you see a really high % transferrin saturation level, you should think
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hemochromatosis, moreso than lead
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rate-limiting step in heme synthesis
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gamma-aminolevulinic acid synthase (sideroblastic anemia)
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bernard soulier disease defect
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GPIb
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glanzmann's thrombasthenia defect
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GPIIB/IIIA
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defect in TTP
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ADAMTS13 (decreases the degradation of vWF multimers)
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list the different types of hodgkins lymphoma from best prognosis to worst
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nodular sclerosing
mixed cellularity Lymphocyte predominant lymphocyte deplted |
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you see a really high % transferrin saturation level, you should think
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hemochromatosis, moreso than lead
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rate-limiting step in heme synthesis
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gamma-aminolevulinic acid synthase (sideroblastic anemia)
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bernard soulier disease defect
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GPIb
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glanzmann's thrombasthenia defect
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GPIIB/IIIA
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defect in TTP
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ADAMTS13 (decreases the degradation of vWF multimers)
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list the different types of hodgkins lymphoma from best prognosis to worst
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Lymphocyte predominant
nodular sclerosing mixed cellularity lymphocyte deplted |
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CD origin for reed sternberg cells
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CD30+ and CD15+
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protein C or S defiency leads to inability to inactivate what factors
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V and VIII
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treatment for vWF disease
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DDAVP (desmopressin)
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???
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burkitts lymphoma (starry sky...sure)
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translocation in burkitts
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8;14)
c-myc moves next to heavy chain Ig gene |
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most common non-hodkins lymphoma in adults
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diffuse large b-cell lymphoma
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mantle cell lymphoma translocation
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t(11;14), leads to overexpression of cyclin D
also CD5+ |
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follicular lymphoma translocation
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t(14;18) bcl-2 underexpression
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findings in multiple myeloma
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hyperCalcemia. Renal insufficiency, Anemia, Bone lytic lesions/back pain
CRAB |
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M spike on electrophoresis
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multiple myeloma or waldenstroms syndrome(hyperviscosity, no bone lesions)
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treat toxicity of tPA or urokinase with
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aminocraproic acid (inhibits fibrinolysis)
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clopidogrel MOA
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blocks ADP receptors. inhibits fibrinogen binding by preventing expression of GpIIb/IIIa
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cilostazol MOA
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PDE III inhibitor...increase cAMP in platelets, decrease aggregation. vasodilator
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Abciximab MOA
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antibody that binds to IIb/IIIa
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bleomycin works at what stage of cell
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G2
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etoposide works at what stage of cell cycle
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G2 and S
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Antimetabolites (MTX, 5-FU) work at what stage of cell cycle
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S
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Vincristine and Vinblastine work at what stage of cell cycle
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M phase
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how do you reverse MTX
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leucovorin(folinic acid)
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MTX MOA
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folic acid inhibitor
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what antimetabolite can't be given with allopurinol
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6-MP...metabolized by xanthine oxidase
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what antimetabolite is a purine analog
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6-MP
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5-FU MOA
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pyrimidine analog, covalently complexes folic acid...inhibits thymidylate synthase
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what do you use in 5-FU overdose
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thymidine
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Cytarabine MOA
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pyrimidine analog... inhibits DNA polymerase
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MTX MOA
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folic acid analog...inhibits dihydrofolate reductase
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