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57 Cards in this Set

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Xolair

omalizumab (Anti IGE)




monoclonal antibody that targets Fc portion on IGE (prevent binding to mast cell)




severe asthma

What portion of IGE does Xolair bind?

constant portion

Zyflo

Zileuton


5-lipoxygenase inhibitor


inhibit leukotriene formation leading to a decrease in smooth muscle contraction (decrease inflammation, edema, mucous secretion)

Accolate

zafirlukast


leukotriene receptor antagonist


inhibits receptor and decrease inflammatory process



How does accolate come? Is it the most effective option?

it is an oral formulation. it is not as effective as albuterol

Pulmicort

budesonide


allows translocation into nucleus leading to suppression of inflammatory mediators and increase in B2 receptors

Foradil

Formoterol


LABA (long acting beta agonist)


stimulates B2 receptors activates cAMP which decreases Calcium and leads to bronchodilation

Why is LABA longer acting than SABA?

partition effect in the membrane of the lungs leading to a long duration of action (more lipophillic)

Proventil

Albuterol (SABA)


Stimulates B2 receptors increasing cAMP activity leading to a decrease in calcium-->relaxation

Parlodel

Bromocriptine


Dopamine agonist


hyperprolactinemia


suppress prolactin production supress HPA axis

Avodart

Dutasteride


5 alpha reductase inhibitor


BPH


decrease size of gland by blocking testosterone to its active metabolite. target glandular tissue in prostate gland



What drug may give you low levels of PSA thus decreasing proper prostate cancer diagnosis

5 alpha reductase inhibitors


(finasteride-proscar & dutasteride/avodart)

amitiza

Lubiprostone


chloride channel activator


acts locally in gut and triggers bowel movement within 48 hours

aqualax

docusate salt


emollient laxative


interacts with hyrophobic and hydrophillic molecules in lumen. prevent constipation

Ortho Evra

combined contraceptive


Do not use in patients over 198 pounds d/t hormonal sequestration of fatty tissue



Nuvaring

combined contraceptive


no precise placement


insert vaginally

Nexplanon

progestin only subdermal implant

depoprovera

progestin only shot


IM/SUB-Q




return of fertility can be delayed for 12 months

Lysodren

Mitotane


Cushing's syndrome


blocks cortisol production


adrenolytic

Cushing's syndrome

"cushion" of cortisol


too much!!

Korlym

mifepristone


glucocorticoid blocker


antagonist and progesterone antagonist

periactin



cyproheptadine


modulator of ACTH


down regulates ACTH


doesnt treat primary



Metopirone

Metyrapone


steridogenesis inhibitors


inhibits the production of cortisol. reduces the production of aldosterone (cushings syndrome)

kalydeco

ivacaftor


used for cystic fibrosis


G551D mutation.


Binds to CFTR protein and allows opening to increase Cl concentration

Mirena

Progestin only

uses of Mirena

dysmenorrhea, endometriosis, contraception

sandostatin

somatostatin (octreotide)


inhibits GI secretion


mimics somato prevents secretion of gastrin and pancreatic polypeptide

danocrine

Danazol (androgen)


blocks gonadotrophin which inhibits menstruation and endometriosis


menopause like


No LH surge, no follicular growth

What are common SE of danazol

hirsutism


harm in pregnancy

What is MOA of emergency contraception?

thickens cervical mucus, inhibits ovulation, and decrease FSH and LH surge

Florinef

Fludrocortisone


mineralcorticoid


potent mineralcorticoid with high effects (can induce cushings syndrome)



Cataflam

Diclofenac


NSAID inhibits COX 1 & 2 decrease prostaglandin formation

Lactaid

Lactase



how does aspirin worsen asthma?

increases production if arachadonic acid eventually leading to an increase in leukotriene formation-->inflammation

Diamox

Acetazolamide


Carbonic anhydrase inhibitor


used for metabolic alkalosis


reduction of H secretion, increase renal excretion of Na, K, bicarb and water

dramamine

Dimenhydrinate

Antihistamine/anticholinergic


competes with histamine in the GI tract. Blocks chemoreceptor trigger zone




Thorazine

Chlorpromazine


Dopamine receptor antagonist


depresses reticular activating system thus decreasing emesis



Lupron

leuprolide


GnRH Supra agonist


Desensitizes GnRH leading to decrease in LH, FSH, estrogen, and progesterone




mimics menopause

What do we have to give if we give a patient lupron?

add back therapy of estrogen + progesterone so they will not have bone resorption

What will bone resorption increase risk of?

osteoporosis

Tracleer

Bosentan


endothelin receptor antagonist


inhibits vasoconstriction and smooth muscle proliferation by antagonizing both EtA and EtB receptors




manages pulmonary hypertension

Revatio

Sildenafil


PDE-5 inhibitor


inhibits PDE5 which converts cGMP->GMP leaving more cGMP thus decreasing Ca (increase dilation)

Name the alpha-1 antagonist

flomax-tamsulosin


rapaflo-silodisin

What does the alpha antagonist do?

relax the stroma of the prostate and intrinsic urethral sphincter leading. UROSELECTIVE.

Does alpha-antagonists change the size of the prostate?

No!! they only relax stroma

Flolan

Epoprostenol


Prostacyclin analog


Acts as a vasodilator and inhibitor of platelet activation. very short half life


IV

Zyban

Bupropion


Nicotinic acetylcholine receptor antagonist


antagonizes NAchr making

Tolvaptan

samsca


selective vasopressin receptor V2 antagonist


increases fluid removal from body




nonemergent euvolemic/ hyervolemic hypotonic

vaprisol

canivaptan


euvolemic/hypervolemic hyponatremia


nonselective vasopressin antagonist


increase excretion of fluid

Name the only non-selective vaspressin antagonist

conivaptan/vaprisol

Name the selective vasopressin antagonists

lixivaptan


mozavaptan


satavaptan


tolvaptan

Olestra

Fat substitute


used for obesity



chantix

varenicline


partial nicotinic agonist


Binds to NAchr decreasing release of dopamine leading to less pleasure when smoking

Mybetriq

mirabegron


B3 agonist.


Activating B3 receptor in the detrusor muscle causing relaxation.


used for urge incontinence

Ditropan

oxybutynin


antimuscarinic (anticholinergic)


inhibits mAchr in the detrusor muscle causing relaxtion

sympathetic nervous --> NE--> ?? the detrusor-->??the internal urethral sphincter-->?? urination

relaxes the detrusor muscle


contracts the internal urethral sphincter


prevention of urination

Parasympathetic nervous-->mACHr-->?? of the detrusor muscle-->?? of the internal urethral sphincter--> ?? urination

contracts the detrusor muscle and relaxes the internal urethral sphincter leading to a increase in urination