Female Sex Hormones

Front 1

FEMALE SEX HORMONESESTROGEN
l Produced in ?(3)
l Regulated by ?
l Stimulates ?
l Stops growth - closes ?
l Menstrual Cycle - growth of ?

Back 1

ESTROGEN
l Produced in ovaries, adrenal gland and testes
l Regulated by FSH
l Stimulates growth & development of sexual organs
l Stops growth - closes epiphyseal plate
l Menstrual Cycle - growth of endometrium and blood supply

Front 2

FEMALE SEX HORMONES
ESTROGEN METABOLIC EFFECTS
4

Back 2

ESTROGEN METABOLIC EFFECTS
l Retention of sodium and water
l Alter glucose tolerance
l Prevent negative calcium balance
l Carcinogenic
• Uterine
• DES babies with cervical cancer
• Breast

Front 3

FEMALE SEX HORMONES
ESTROGEN THERAPEUTIC USE
6

Back 3

ESTROGEN THERAPEUTIC USE
l Oral/patch contraception with a progesterone
l Menopausal symptoms
l Increase bone density (no longer approved for this use)
l Atrophic vaginitis
l Dysmenorrhea
l Cancer - prostate

Front 4

FEMALE SEX HORMONES
ESTROGEN SIDE EFFECTS

Back 4

ESTROGEN SIDE EFFECTS
l Nausea - tolerance develops
l Mid cycle bleeding
l Breast tenderness
l Increased blood clotting
• avoid in smokers
• avoid BCP over age of 45

Front 5

FEMALE SEX HORMONES
SPECIFIC ESTROGEN RECEPTOR MODULATOR
3
1 ex?

Back 5

l Non-estrogen that stimulates estrogen receptor
l Indicated for increased bone density for those that cannot tolerate estrogens
l example: Raloxifene (Evista®)

Front 6

FEMALE SEX HORMONES
PROGESTERONE
5?

Back 6

PROGESTERONE
l Produced in corpus luteum after ovulation
l Regulated by LH
l Corpus luteum regresses after 14 days if ovum is not fertilized
l Prepares endometrium for implantation
l Increases basal body temp 1°C

Front 7

FEMALE SEX HORMONES
PROGESTERONE THERAPEUTIC USE
5?

Back 7

PROGESTERONE THERAPEUTIC USE
l Uterine Bleed due to ovulatory failure
l Dysmenorrhea
l Contraception with or without estrogens
l Protect uterus from estrogen induced cancer
l Endometrial cancer

Front 8

FEMALE SEX HORMONES
ORAL/PATCH CONTRACEPTIVES
4

Back 8

l 99% effective
l Stops Ovulation
l Cervical gland produces mucous so sperm cannot pass
l Progesterone alone administered daily
l Progesterone with an estrogen administered for 21 days

Front 9

FEMALE SEX HORMONES
GENERAL INFORMATION
3

Back 9

l Not effective during the first month of therapy
l If one dose is missed then double the next dose, if two doses is missed then double for two days
l Discontinue for three months prior to pregnancy

Front 10

FEMALE SEX HORMONES
Side Effects for bc
5

Back 10

Side Effects
l Nausea/vomiting
l Headache
l Weight gain
• Tolerance develops to all above
l Acne
• Lower incidence with tri-phasic birth control pills
l Melasma