Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
reverse methotrexate with?
|
leucovorin (folic acid)
|
|
|
methotrexate weird toxicity
|
macrovascular fatty changes in liver, mucositis
|
|
|
recombinant GM-CSF used for myelorecovery / post transplant
|
sagramostin
|
|
|
G-CSF used to prevent/rx chemo-febrile neutropenia & promote myeloid recovery
|
filgratin
|
|
|
Oprelvekin
|
recombinant IL-11, increases hematopoietic stem cells & megakaryocyte progenitor, used in thrombocytopenia
|
|
|
5-FU moa and reversibility
|
pyrimidine analogue (stops formation of t from u) blocks thymidylate synthase, reverse with thymidine
|
|
|
6 mercaptopurine - moa, toxicity
|
prodrug act by HGPRTase, block de novo syn, metabolized by xanthine oxidase so toxicity with allopurinol
|
|
|
cytarabine - moa, use and weird SE
|
inhibits DNA pol (crosses BBB), AML, megaloblastic anemia
|
|
|
cyclophosphamide/ifosfamide: moa, weird side effect
|
alkylating / cross linking at guanine N-7, needs liver activation; hemorrhagic cystitis (part prev w mesna)
|
|
|
nitrosureas - name them, mechanism of action, special use, toxicity
|
carmustine, lomustine, semustine, streptozocin
alkylate DNA, needs to be activated, crosses bbb RX brain tumors SE: pulmonary toxic, CNS tox |
|
|
cisplatin, carboplatin - MOA, weird SE
|
act like alkylating agents, nephrotoxic and acoustic nerve damage (drink more h20)
|
|
|
busulfan - moa, use, weird se
|
alkylates DNA, CML, pulmonary fibrosis, hyperpigmentation, cataracts
|
|
|
mitomycin - moa
|
ss breaks, hypoxic activation in tumor cells
|
|
|
doxorubicin, daunorubicin - moa, weird SE, reversibility of SE
|
free radicals + noncovalent interaclation in DNA
SE: cardiotoxic (use dexrazoxane), toxic extravastion |
|
|
dexrazoxane - moa, purpose
|
Fe chelator, decreases cardiomyopathy from doxorubicin
|
|
|
dactinomycin - moa, use
|
intercalate, act out > childhood tumors (wilm's, ewings, rhabdo)
|
|
|
bleomycin - moa, unique use, weird SE
|
free radicals / dna break, radiomimetic
use: skin / lung pulmonary fibrosis, skin changes |
|
|
what's awesome about bleomycin?
|
minimal myelosuppression
|
|
|
hydroxyurea - moa
|
inhbits ribonucleotide reductase/decreases DNA syn (s phase)
|
|
|
noncancer use for hydroxyurea
|
sickle cell
|
|
|
etoposide: moa, use, weird SE
|
G2 phase inhibits topoII / increases DNA degradation
use: SCLC, prostate, testicular carcinogen |
|
|
Dacarbazine - moa, use, SE
|
DNA methylation
met melanoma, osteosarcoma SE - carcinogenic, p450 |
|
|
benefit of raloxifene over tamoxifene
|
doesn't cause endometrial cancer - not an endometrial antagonist
|
|
|
trastuzumab / herceptin SE
|
cardiotoxic
|
|
|
imatinib / gleevac - other uses, SE
|
GI stromal tumor
fluid retention |
|
|
imatibib - bind active or inactive site on Abl? what binds the other form?
|
inactive ATP!
dastainib binds active form / more potent |
|
|
whats awesome about vincristine
|
less bone marrow suppression
|
|
|
vincristine/vinblastine moa, se
|
block polymerization of mt
vincristine - neurotoxic, paralytic ileus vinblastine - bone marrow suppression |
|
|
taxols moa
|
not soluble - G2/M phase prevent breakdown of mt spindles
|
|
|
bevacizumab - moa, use
|
VegFmab
colorectal, NSCLC met |
