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10 Cards in this Set
- Front
- Back
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What part of vitamin K’s chemical structure makes it fat-soluble?
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The methy tail
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What are the two forms of vitamin K and how are they absorbed? How is Vit K's absorption and its storage in the body different or the same as the other fat-soluble vitamins?
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K1 (from plants) - absrobed into enterocytes actively
K2 (from bacteria) - absorbed into enterocytes passive All other fat soluble vitamins are absorbed into enterocytes passively only. Both K1 and K2 are then transported to the liver by chylomicrons like all other fat-soluble vitamins. |
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Besides the diet, what is one other source of vitamin K?
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Enteric flora
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Describe the role of vitamin K in blood clotting.
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Vitamin K is a cofactor that helps clotting factors prothrombin convert to thrombin which then acts on fibrinogen --> fibrin to create blood clotting. Without vitamin K, blood favors bleeding over clotting.
Specifically it turns Glu --> Gly |
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What is the mechanism of action of warfarin, and what is the therapeutic use of this drug?
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Warfarin interferes with the recycling of vitamin K, thus interfering with the production of bioactive clotting factors. The therapeutic use is to thin the blood for patients at risk for heart attack or stroke.
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What food groups contain foods with a high density of vitamin K?
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Dark leafy vegetables and other green vegetables, oils are good dietary sources
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What is PT?
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PT is prothrombin time; measures the time it takes for a patients blood to clot. More vit. K = lower PT. Normal results = 10-13 seconds
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What is INR, and what is its relationship to PT?
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INR is international normalized ratio. Ideal range is 0.8 – 1.2. This compensates for differences in tissue factor source and instrumentation used.
If PT goes up, iNR goes up |
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What is an easily recognizable symptom of vitamin K deficiency?
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Bleeding
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Describe at least three ways in which diet, medical condition and current medications can lead to vitamin K deficiency
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Lack of vitamin K in the diet (newborns), fat malabsorption or biliary cobstruction (medical condition) or chronic antibiotic use resulting in a loss of bacterial vitamin K absorbed in colon can all lead to vit. K deficiency.
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