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61 Cards in this Set

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Anxiety-related Disorders: Anxiety Disorders



Specific Phobias, Panic Disorder, Agoraphobia, Social Anxiety Disorder, Generalized Anxiety Disorder

Anxiety-related Disorders: Obsessive-Compulsive and Related Disorders

Obsessive - Compulsive Disorder

Anxiety-related Disorders: Trauma- and Stressor- related Disorders

Post Traumatic Stress Disorder, Acute Stress Disorder

Mood-related Disorders: Depressive Disorders

Major Depressive Disorder, Persistent Depressive Disorder

Mood- related Disorders: Bipolar Disorders

Bipolar I Disorder, Bipolar II Disorder, Cyclothymic Disorder

Anxiety Disorders - Specific Phobia: Clinical Picture

- Disruptive fear of particular OBJECT or SITUATION


- FEAR > actual threat


- Aware fear is excessive


- Must cause distress or impairment


-MORE MORE MORE





Anxiety Disorders - Specific Phobias: Categories

- Animal: snakes, insects


- Natural environment: storms, water


- Blood, injection, injury: needles


- Situational: Elevators, flying


- Other: if fall under none of the 4

Anxiety Disorders - Specific Phobias: Facts and Stats

- Women > Men (4:1)


- Seen worldwide (objects of fear vary)


- Treatment seeking is low


- Age of onset:


----- Situational --> older (20s)


-----The rest --> childhood- adolescence

Anxiety Disorders - Panic Disorder: Clinical Picture

- Frequent uncued panic attacks unrelated to specific situations


- Uncued attacks: expected


- Cued attacks: triggered (e.g., phobia)


- Anxiety


- The panic cycle: Bodily sensation --> Panic attack --> High anxiety --> fear of fear

Anxiety Disorders - Panic Disorder: Facts and Sats

- 4.7% lifetime prevalence (US)


- Exists worldwide


- 8-12% - occasional panic attacks


- Women > men


- Onset late adolescence - early adult


- 60% have nocturnal attacks

Anxiety Disorders - Agoraphobia: Clinical Picture

Anxiety about certain public situations (crowds, malls) -- inability to flee or obtain help

Anxiety Disorders- Agoraphobia: Facts and Stats

1.7% lifetime prevalence

Anxiety Disorders - Social Anxiety Disorder

- Intense fear of social situations


-----Fear of negative evaluation, embarassment, blushing, sweating.


- Situation- specific (public speaking or broad)

Anxiety Disorders - Social Anxiety Disorder: Facts and Stats

- 12.1% lifetime prevalence (US)


- Women = men


- Onset in childhood adolescence


- Culturally - specific presentations (ex. fear of offending in Japan)

Anxiety Disorder - Generalized Anxiety Disorder: Clinical Picture

- Excessive, uncontrollable worry - unproductive, chronic, minor, daily events (health, finances)


- Other symptoms: irritability, restlessness, fatigue, tension

Anxiety Disorder - Generalized Anxiety Disorder: Facts and Stats

- 5.7% Prevalence (US) - similar rates around the world


-2/3 women


- Adult onset - gradual, common in older adults

Obsessive-Compulsive Disorder: Clinical Picture

- Repetitive thought and urges (obsessions)- intrusive, persistent, and uncontrollable




-Repetitive behaviors/mental acts (compulsions) - extremely difficult to resist, may not be logically linked to obsession

Obsessive- Compulsive Disorder: Common Obsession and Compulsion links

- symmetry --> ordering, arranging, repeating


- cleaning & contamination --> Washing, cleaning


- Hoarding --> collecting, saving


-Forbidden thoughts or actions --> checking



Obsessive - Compulsive Disorders: Worries can FEEL real

- Imagine you were truly fearful you would accidently set a fire in your room?


- What would you do to minimize this fear? - Get rid of all flammable objects and firestarters, constantly check on stove, outlets, etc. (or completely stay away from using them)


-Say prayers, and perform rituals to keep safe

Obsessive- Compulsive Disorder: Facts and Stats

- 1.8% lifetime prevalence (US) 10-15% normal college students "checks"


- Looks similar across cultures


- Women = Men


- Boys > girls


- 50% seek treatment


- Onset late adolescence - adult


- 1/3 develops in children

Trauma and stress related disorders - Post- traumatic Stress Disorder: Clinical Picture

- Severe stressor - traumatic event that involves actual or threatened death or injury (learning about trauma, repeated exposure to details)


- Extreme reponse


- Symptoms presents for more than a month

Post- Traumatic Stress Disorders: PTSD Symptoms Categories

- Re-experinecing the traumatic events


----- Nightmares, intrusive thoughts




- Avoidance of stimuli (association)




- Other mood and cognitive changes


----other mood and cognitive changes




- Increased arousal and reactivity


------E.g., irritability, aggressiveness, startle response



Post - Traumatic Stress Disorders: Facts and Stats

- 6.8% lifetime prevalence (US)


- Most common traumas - combat, sexual assault




- Trauma is necessary, not sufficient


-------50-60% of adults will experience trauma


------- 4.7% of those experiencing combat


- Onset any age

Acute Stress Disorder: Clinical Picture

- Symptoms similar to PTSD


----- 3 days - 1 month after trauma




- 50% go on to develop PTSD


- Allows insurance coverage --> prevention


- SOCIAL SUPPORT

Acute Stress Disorder: Prevalence rates

- Any anxiety-related disorders --> very common (US)


- 18% of adults in past year


- ~30% in lifetime


- Symptoms can range from mild-severe




Comorbiditieis common


- Other anxiety disoderes (50%)


- Other mental disorders (75%) - depression, substance use disorders


- Health disorders (migranes, cardiovascular disease)





Course of Illness



- Varied (some improve, some get worse, some flutuate) - OCD, PTSD, Panic Disorder,




- Persistent: Specific phobias, GAD (develops gradually), agoraphobia, social anxiety disorder

Anxiety- related Risk Factors: Biological

- Genetic


---- ~0.5 heritability - specific anxiety-related disorders


----- Tendency to be uptight, tense, anxious




- Evolutionary preparedness,


----- Phobias, social anxiety



Anxiety- related Risk Factors: Biological(Brain Features)

- Impairment in limbic system?


------ Brain stem: monitors change in body function


------Limbic system: mediates btw brain stem and cortex


--- Amygdala (threat reponse, learning, memory)


---- Hippocampus (threat response, learning, memory)


Cortex: regulating limbic system





Anxiety- related Risk Factors: Biological (brain features - Neurochemical Features)

- Chronic increased cortisol - lowers ability to turn off stress response (cell death in hippocampus


- Stress response system impacts other systems (limbic system, brain stem, prefrontal cortex, and neurotransmitter systems) - seratonin (mood, impulsive), GABA (anxiety inhibition, motor control), Norepinephrine (fight or flight),

Anxiety - related Risk Factors: Psychobiological Risk Factors

- Temperament (inherited?): - Behavioral inhibition (shy, cautious, anxious)


----- Anxiety infants --> anxious children/adolescents




Neuroticism (negative emotional reactions)


----- More negative emotions --> more emotional disorders

Anxiety -related Rik Factors: Psychological- Cognitions

- Perceived lack of control


- Negative beliefs about future


- Anxiety sensitivity

Anxiety -related Rik Factors: Psychological- Learning Factors

Two-factor model


--- Event: scary experience/observation/ warning


1. Response to threat (classical conditioning) - dogs / parks / anxiety symptoms are scary




2. Anticipatory anxiety --> avoidance (operant conditioning)




3rd factor: Stressor activates biological vulnerability

Anxiety -related Rik Factors: Sociocultural

- Family Factors: teaching caution, fear, typvial response to stress


- Stressful life events: interpersonal stressors in particular



Major Depressive Episode: Clinical Picture

Sad/empty mood and/or loss of interest/pleasure (anhedonia)


PLUS


- Cognitive symptoms: worthlessness, guilt, decreased concentration, thoughts of death)


- Physcal symptoms (appetitie/weight change, sleep changes, psychomotor changes, fatigue)




--> 2+ week period


--> Not a "normal" response to loss/stressor


--> Typical episode: 2-9 months (untreated) --> NOT chronic course




- 1+ major depressive episode




- Additional ratings: Episode/ recurrence (35-85% 1+ episode), Severity (dimensional rating), Features (psychosis? Postpartum? Season? Anxious?), "unipolar depression"




PREVALENCE 16.6%

Persistent Depressive Disorder: Clinical Picture

- Chronic low mood for at least 2 years (no break of 2+ mons)


- Lower intensity symptoms (typically) not more "severe" - chronic


- May or may not have ALSO had major depressive episode - "double depression" ~ 20%


- Used to be called "dysthymia"


- Prevalence: 2.5%

Manic episode: Clinical picture

- Elevated or irritable mood


- AND persistently increased goal - directed activity or energy - lasting 1 week (< if severe)





Manic episode: Clinical picture - Cognitive symptoms

Flight of ideas/ racing thoughts, grandiosity

Manic episode: Clinical picture- Physical symptoms

Hyperactivity, decreased sleep, rapid speech)

Manic episode: Clinical picture- Behavioral symptoms

increase in pleasurable high-risk activities

Hypomanic episode: clinical picture

-


- No marked impairnment in functioing


- Shorter tie period (at least 4 days)

Bipolar Disorders: Bipolar I Disorder

1. +/- depressive episodes


2. >= manic episode


3. +/- hypomanic episodes

Bipolar Disorders: Bipolar II Disorder

1. >= major depressive episode


2. 0 full manic episode


3. >= 1 hypomanic episode

Bipolar Other facts

- 10-15% Bipolar II --> Bipolar


- Specifiers ( psychosis, rapid cycling)


- Chronic course (overall pattern, not each episode)


- PREVALENCE: 3.9%

Cyclothymic Disorder: Cilinical Picture

- Hypomania AND lower-intensity symptoms of depression


- 2-year duration


- 15-50% will go on to develop Bipolar I or II disorder


- Chronic Course


-Prevalenece ~ 1.5%

Cyclothymic Disorder: Facts and Stats

- Common: Any mood disorder: 20.8%


- Lots of Comorbidity


- Suicide'


- Not actually as "polar" as we think


------- 70% in depressive episode also had some manic symptoms

Other influential factors: Gender

- Depressive disorders: Women > Men (70% women, wordwide)


- Bipolar disorders: Women = Men



Other influential factors: Culture

- Depressive disorders: cultural variability (prevalence; symptoms)


- Bipolar: nor as much culturally variability

Other infuential factors: Typical age onset

- Depressive disorders: adulthood (variable, more than 50% over 65)


- Bipolar: late adolescence, acute onset not usually after 40

Mood Disorders: RISK FACTORS

Heritability estimates: .37 - .5 depressive disorders ---> higher in women; enviorment --> men




.75 - .80 for Bipolar Disorders


- Genetics of mania - distinct


- Maina - schizophernia


-Depressive = anxiety disorders

MD Risk Factors: Biological - Prefrontal cortex and limbic system

· E.g., anterior cingulate cortex – goal pursuit, motivation


· E.g., hippocampus and emotional learning

MD Risk Factors: Biological: Seratonin

· Low serotonin? (absolute levels of NTs)· More nuanced: Serotonin à regulates mood ANDother NT systems (dopamine, norepinephrine)

MD Risk Factors: Biological: Dopamine

· Drugs that increase dopamine --> hypomania


· Sensitive reward circuits? (also a cognitivefactor!) some people have this

MD Risk Factors: Biological:Neurohormones

· WTF is exactly going on with NTs?
· More attention on stress hypothesis
o Stresshormones also regulate basic functions (e.g., sleep, appetite)
o Endocrinediseases (disease (e.g., hypothyroidism) àdepression
o Over-activestress response --> cortisol --> depression
---- Celldeath in the limbic system – NTs can’t do their job
-----Similarto anxiety disorders?

MD Risk Factors: psycobiological

- Temperment: Neuroticism (reacting with negative emotion) --> predicts onset of depression




- Sleep and bipolar disorders:


-----Sleep deprivation, circadian rhythm disruption as triggers?

MD Risk Factors: Psychological

- Cognitive theories of depression: - Depressive Triad: Self, world, future - Hopelessness Theory ("learned helplessness")


---- Negative event --> stress --> helplessness and out of control --> anxiety --> hopeless about coping --> depression


----Attributions are : internal: my fault, stable: never going to change, global: will always be true

MD Risk Factors: Sociocultural

- Stress and life events --> Onset


---- Interpersonal (social rejection) --> depression


---- Behavioral (goal achievment) --> mania


----But 50-80% of people who experience severe stress are fine!




- Marginalized group status (discrimination, poverty, etc)


- Social support (risk of depression if living alone, pets help)

Worry:

Cognitive; concern about future threat - potential threat

Anxiety

Emotional state; physical, cognitive, behavioral parts - approaching threat

Fear

Specific threat response; physical arousal, imminent threat

What is mood?

- temporary state of mind or feeling


- Normal reactions to events (sadness, joy)

Mood disorders?

- Extreme poles


-Extremely happy or sad


- Much more than just happy or sad