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18 Cards in this Set
- Front
- Back
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Understand strengths and weaknesses of psychoneuroimmunology research
-Strength: ... and ... applications are being developed -Weakness: most are ..., human research has ... focus Understand that psychoneuroimmunology suggest a integrative clinical approach -... -system contribution to a single diagnosis -addressing ... systems involved provides better recovery and overall health |
research and clinical
correlational limited multi all |
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Like the name suggests, psychoneuroimmunology is the experimental and clinical idea that three components mutually affect each other
1) ... - emotion, experiences, mood, personality, thought, and more 2) The ... system - central and peripheral, sympathetic and parasympathetic 3) The ... system - microglia, mast cells, interleukins, histamines, and more |
Psychology
nervous immunological |
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... is the most common neurodegenerative movement disorder.
- The classical form of the disease is characterized clinically by rigidity, resting tremor, bradykinesia and postural instability. -Its pathological hallmarks are the preferential loss of ... neurons of the substantia nigra pars ... and formation of ... bodies; intracytoplasmic inclusion bodies that are mainly composed of fibrillar a-synuclein. -The clinical symptoms of PD arise by a ... effect. |
Parkinson's disease (PD)
dopaminergic compacta Lewy threshold |
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... is produced in all mammalian tissues.
It is produced in the pathway involving AcylCoA which also synthesizes cholesterol. One of the first steps in this pathway involves HMGCoA which requires HMGCoA reductase for conversion. ... are HMGCoA reductase inhibitors. Therefore persons on ... are at risk for problems with Coenzyme Q10 levels. |
Coenzyme Q10
STATINS STATINS |
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Chronic levodopa administration alters cerebral ... respiratory chain activity
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mitochondrial
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... disease is a fatal genetic lipid storage disorder
it is autosomal ... |
Tay-Sachs
recessive |
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Tay-Sachs is a genetic deficiency of the lysosomal enzyme ...
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beta-hexosaminidase
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Biochemistry of Tay Sachs:
Fatty acids called gangliosides (a ...) are made and biodegraded rapidly in early life as the brain develops -... catalyzes the biodegradation of gangliosides -With beta-hexoaminidase absent, harmful quantities of ganglioside GM2 build up in tissues and nerve cells -These cells stop functioning normally |
sphingolipid
Beta-hexosaminidase A |
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Tay Sachs – take home message:
Faulty ... (potential treatment) --> faulty ... (potential treatment) --> intracellular ... storage error --> neuron damage and death --> ... nervous system failure (current pallative treatments) --> disability and ... |
gene
enzyme lipid central death |
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Sporadic or late onset AD:
No direct causal genetic link found Related to the ... gene found on chromosome 19 |
apolipoprotein E (APOE)
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The APOE gene comes in several different forms, or alleles, three of which occur most frequently:
APOE e2 (which ... the risk) APOE e3 APOE e4 (which ... the risk) |
decreases
increases |
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Unlike Tay-Sachs, late onset Alzheimer’s Disease ... directly linked to any autosomal dominant or autosomal recessive gene
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is not
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... factors must contribute to the development of AD
-Age is the greatest risk factor -Traumatic brain injury increases risk -Use of non-steroidal anti-inflammatories, statins, and estrogen are associated with reduced risk |
Environmental
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ApoE binds to ...
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beta amyloid
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Beta-amyloid is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients
-Aggregates ... the cell |
outside
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Abnormal tau inhibits:
Cellular ... early in AD -Intracellular transport of metabolic products, neurotransmitters, critical chemicals |
communication
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Early stage AD chain of events:
Beta-secretase increases beta amyloid generation APOE e4 gene promotes beta amyloid aggregation Tau damages intracellular microtubule structures -Neurons cease to ... Beta amyloid aggregates outside the neurons & glia -Cortical atrophy is not evident Early AD –... changes with little or no gross ... changes measurable in vivo -Mild cognitive impairment (MCI) -Extensive insight |
communicate
functional structural |
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look at slide 26 on lecture 63/64
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ok
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