Exam 1, Immunology & Serology

Front 1

Example of naturally required immunity?

Back 1

Maternally derived antibody in a newborn infant

Front 2

Resistance to infection following recovery from viral infection is known as

Back 2

Naturally acquired active immunity

Front 3

The major cellular component of adaptive immunity is

Back 3

Lymphoctye

Front 4

The major humoral component of adaptive immunity is

Back 4

Antibody

Front 5

In which organ do T lymphocytes mature?

Back 5

Thymus

Front 6

A hapten is

Back 6

An antigenic determinant capable of stimulating an immune response only when bound to a carrier molecule

Front 7

Immunogenic refers to

Back 7

The ability of a substance to cause an immune response

Front 8

The hypervariable regions of an immunoglobulin are:
1. All important parts of the Ag bind site of an Ab
2. Found in both heavy chains
3. The same in IgG and IgM produced by plasma cell after it switches from IgM synthesis to IgG synthesis
4. All of the above

Back 8

All of the above

Front 9

Which immunoglobulin class(es) has/have a J chain?

Back 9

IgA & IgM

Front 10

Which immunoglobulin help initiate the complement pathway?

Back 10

IgG & IgM

Front 11

The 5 immunoglobulin classes in order of decreasing concentration

Back 11

IgG > IgA > IgM > IgD > IgE

Front 12

How many potential antigen binding sites does an IgG molecule have?

Back 12

Two

Front 13

The normal ratio of helper:cytotoxic cells

Back 13

2:1

Front 14

T cells are incapable of

Back 14

Secretions of immunoglobulins

Front 15

The immunoglobulin class that associates with allergic reactions is

Back 15

IgE

Front 16

T helper cells have which kind of surface markers ?

Back 16

CD4

Front 17

Humoral antibody are produced by which cell line ?

Back 17

B lymphocytes

Front 18

Which immunoglobulin is a pentamer ?

Back 18

IgM

Front 19

The proper term for the cell surface markers referred to as "self antigen" is

Back 19

Major histocompatibility complex

Front 20

Which is most actively phagocytic leukocyte and antigen processing cell originating in the blood?

Back 20

Monocyte

Front 21

Which immunoglobulin is considered part of the nonspecific immune system ?

Back 21

IgA

Front 22

The most defense functions of monocytes/macrophages include:
1. antigen presentation
2. phagocytosis
3. induction of the immune response
4. secretion of biologically active substances
5. all of the above

Back 22

All of the above

Front 23

Which complement component is present in the greatest concentration in normal patient serum ?

Back 23

C3

Front 24

Which complement component is not part of the Lectin pathway ?

Back 24

C1

Front 25

Thymus is primary or secondary lymphoid tissue ?

Back 25

Thymus

Front 26

Which lymphocytes are considered part of nonspecific immune response because they destroy ay infected cell regardless of the antigen causing the infection ?

Back 26

Natural killer cells

Front 27

Which tissue cell does not originate in the blood and is capable of phagocytosis and presentation of an antigen ?

Back 27

Neutrophil

Front 28

Which complement component is not part of the MAC:
a. C5
b. C9
c. C6
d. C4

Back 28

C4

Front 29

Which complement component is exclusive to the alternative pathway ?

Back 29

Factor B

Front 30

Actively involved in parasitic infection

Back 30

Eosinophil

Front 31

Actively involved in bacterial infections

Back 31

Neutrophils

Front 32

Referred to as MAST cell when present in tissue

Back 32

Basophil

Front 33

Referred to as a macrophages when present in tissue

Back 33

Monocyte

Front 34

Main cellular component of cell mediated immunity

Back 34

T lymphocytes

Front 35

Main component of humoral immunity

Back 35

B lymphocytes

Front 36

Mediates inflammation by causing MAST cells to release histamine

Back 36

Anaphylatoxin

Front 37

Enhance phagocytosis by coating the surface of foreign particles

Back 37

Opsonin

Front 38

Disrupt cell membrane resulting in destruction of cell

Back 38

Cytolysis

Front 39

Stimulate the migration of phagocytic cells to the damaged area

Back 39

Chemotaxins