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12 Cards in this Set
- Front
- Back
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Ethosuximide works by what mechanism in CAE? |
Blocks T-type calcium channels. FYI: GAERS rat model of absence has increased expression of T-type calcium channels |
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Atypical absence seizures clinical and EEG characteristics? |
15 sec to minutes. Postictal confusion. 2-2.5 Hz spike and slow waves |
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ILAE revised etiology classification |
Genetic, structural/metabolic, unknown |
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Benign familial neonatal convulsions: presentation and genetics? |
Frequent, brief, first days of life, 15% risk for seizures later in life. AD 85% penetrance. KCNQ2, KCNQ3. Voltage-gated K channel |
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KCMQ2 and 3 mutation drug of choice? |
Ezogabine. Stabilized the affected K channels |
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Enzyme inhibitors |
VPA Felbamate |
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Enzyme inducers |
PHB Primidone PHT CBZ |
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Oral contraceptives do what to LTG clearance? |
Enhance/speed up clearance of LTG |
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Oral contraceptive clearance is increased by which ASMs? |
CBZ PHB PHT Primidone OXC Esliscarbazepine Perampanel TPM (over 200mg/day) |
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VPA plus LTG causes what interaction? |
VPA markedly increases LTG (but the two can be synergistic together) |
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VPA added to CBZ gives what effect? |
VPA decreases clearance of the CBZ breakdown product 10-11 epoxide (effect not the same with OXC) |
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Hepatically metabolized drugs? |
CBZ PHT PHB VPA LTG OXC ZNS TPM ETX Tiagabine |
