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55 Cards in this Set

  • Front
  • Back
inflammation of the brain parenchyma, presents as diffuse and focal neurophysiological deficits
Encephalitis
Etiologies of encephalitis
- 2 MC
-exculsive- neonates
- Arboviruses
- Herpes simplex I, II
General viral prodrome- encephalitis
fever, headache, nausea, vommtiing, lethargy, myalgias- several days long
Classic Presentation of Encephalitis
AMS, stiff neck, photophobia, seizures, flaccid
Physical findings- encephalitis
AMS, Movement disorders, ataxia, dysphagia, unilateral sensorimotor dysfunction
Diagnostic evaluations- encephalitis
CBC w/ diff- normal, UA- normal, Serum electolytes (SIADH-25%), BMP, CSF- i,ncreased mononuclear cells, normal gulcose, elevated protein, oligoclonal bands observed
CT before or after LP- encephalitis
before
How to tx
HSV encephalitis
- acyclovir
- w/ or without antibotics/steriods
Should you collect samples and blood cultures before or after therapy?
before
Emergency Managment of Encephalitis?
manage fever and pain
give fluids- for hypotension
early diuresis- lasix, manitol
dexamethasone
hyperventilation
AN inflammation of the archnoid , the pia matter, CSF, eventually extending throughout the CNS.
Meningitis
Populations more exposed to meningitis?
infants, young children, > 60 yrs
Common Bacteria-neonates for meningitis
s. agalactaiae
E. Coli
L. Monocytogenes
Common bacteria in older children, teenagers, adults < 50- -menningitis
N. Meningitis, S. Pneumoniae, H. Influenzae
Common bacteria in> 50- menningitis
- L. Monocytogenes, N. Meningitis, S. Pneumoniae
What is the most common syndrome affecting the CNS?
Aseptic meningitis syndrome
The classic presentation of meningitis?
fever, headache, neck stiffness, photophobia, nausea, vomiting
Meningitis Triad
fever, nuchal rigidity, AMS
Physical Exam Findings- meningitis
Kernig's, Brudinski's signs
headache, fever, nuchal rigidity AMS
petechial, purpuric, ecchymotic rash w/ meningeal findings?
Meningococcal infection
Diagnostic evaluations- meningitis
CBC w/ diff ( left shift- bacterial), blood cultures, CSF: chemistry, opening pressure, cell count, gram stain and culture
Imaging for meningitis
CT- before LP
CSF results : bacterial meningitis
: opening pressure 200-300, WBC 100-5000> 80% PMNs, glucose< 40, Protein >100, + culture
CSF results: viral meningitis
opening pressure- 90-200, WBC- 10-300 lymphs, Glucose- normal/reduced, Protein- slighlty elvated, neg- culture
Medical Management - meningitis
Initial tx as bacterial if cannot be r/o
In older children & adults- cefotaxime or ceftriaxone, vancomycin
in adults > 50 years ampilcillin is added to vanco and 3rd gen cephalosporins
dexamethasone in children before 3rd gen cephalosporin
How long should meningitis infection of L. monocytogenes be treated for?
21 days
prompt prophylaxis is warranted for contacts of a meningococcal patient? T or F
True
a nuerological deficit that lasting more then 24 hours that is caused by reduced blood flow in an artery supplying part of the brain- leads to infarction
Stroke
2 types of strokes
hemorrhagic
ischemic
ischemic strokes counts for % of strokes
85%
Most common disorder that leads to stroke
Athersclerosis
Athersclerosis can cause stroke in three different ways:
*mural thrombosis- obstructs artery
*ulceration or rupture of the the plaque- leads to clot
*hemorrhage into a plaque obstructs artery
Risk factors for Stroke:
hypertension, smoking, heart disease, hypercholesterolemia, disease associated increased viscosity of the blood, OCPs
What is the most important risk factor for a stroke?
HTN
If stroke symptoms reslove within 1-2 hours patient had a ?
TIA
Sings and symptoms of stroke
drooping of facial muscles- can wrinkle forehead, paresis, visual loss, diplopia, dysarthria, aphasia, decreased level of consiousness
Stroke of what artery produces: contralateral hemiparesis, contralateral hyperhesia, ipsilateral hemianopsia, gaze preferenace toward lesion, weakness of upper extremities > lower exremities
MCA
What artery stroke causes: producing primary reflexes, AMS, imparied judgement, contralateral weakness, contralateral cortical sensory deficits, apraxia, urinary incontinence
ACA
what artery stroke causes: homonymous hemianopsia, cortical blindness, visual agnosia, AMS, impaired mental status
PCA
Infarct of what artery causes: nystagmus, vertigo, diplopia, visul fields deficits, dysphagia, dysarthria, syncope, ataxia
Vertebrobasilar artery
Hallmark of posterior circulation loss?
ipsilateral cranial nerve deficit and contralateral motor deficits
Diagnostic evaluations of stroke?
CBC, ESR- giant cell arteritis, blood gulcose, prothrombin time and partial thrombin time, EKG
Imaging for stroke
CT scan- standard initial imaging study, MRI- most sensitive
What is the gold standard imaging study for a cerebral stroke?
cerebral angiography
Emergent management for a Cerebral Stroke?
Thrombolytic therapy- only safe and effective way for acute managment of stroke: t-pa- start within 3 hours- if hypertensive (185/110) give labetol m(BB) before starting t-PA
a prolonged seizure that last > 30 min
Status Epilepticus
physical exam findings- status epilepticus
complusive: generalized/focal seizure activity
non-convulsive: confusion, delirium, bizzare behavior, memory loss catatonia
changes in respiration, temp, bp
Emergency management - status epilepticus?
ABCs, IV, ECG, Thiamine, D50- unless glucose known, Lorazepam, Diazepam, phenytoin, phenobarb, propofol
Diagnostic evaluations- status eplilepticus
antiepileptic drug levels, CBC, CMP, CT, ECG, LP, UA tox
when are the peak incidences of epilepsy?
childhood and elderly
Partial seizure -def
involve localized region or collection of cells in a specific area that display a bursting behavior
Generalized seizures
diffuse clinical and EEg changes that involve many areas of the brain
do simple partial seizures have altered consciousness?
no
When is a partial seizure become complex?
when consciousness is altered
Generalized clonic-tonic seizure- physical findings
patient becomes stiff, clonic, rhythmic jerking of all four extremities, diaphoretic, urinary incontinence, cyanosis