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55 Cards in this Set
- Front
- Back
inflammation of the brain parenchyma, presents as diffuse and focal neurophysiological deficits
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Encephalitis
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Etiologies of encephalitis
- 2 MC -exculsive- neonates |
- Arboviruses
- Herpes simplex I, II |
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General viral prodrome- encephalitis
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fever, headache, nausea, vommtiing, lethargy, myalgias- several days long
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Classic Presentation of Encephalitis
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AMS, stiff neck, photophobia, seizures, flaccid
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Physical findings- encephalitis
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AMS, Movement disorders, ataxia, dysphagia, unilateral sensorimotor dysfunction
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Diagnostic evaluations- encephalitis
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CBC w/ diff- normal, UA- normal, Serum electolytes (SIADH-25%), BMP, CSF- i,ncreased mononuclear cells, normal gulcose, elevated protein, oligoclonal bands observed
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CT before or after LP- encephalitis
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before
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How to tx
HSV encephalitis |
- acyclovir
- w/ or without antibotics/steriods |
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Should you collect samples and blood cultures before or after therapy?
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before
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Emergency Managment of Encephalitis?
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manage fever and pain
give fluids- for hypotension early diuresis- lasix, manitol dexamethasone hyperventilation |
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AN inflammation of the archnoid , the pia matter, CSF, eventually extending throughout the CNS.
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Meningitis
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Populations more exposed to meningitis?
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infants, young children, > 60 yrs
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Common Bacteria-neonates for meningitis
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s. agalactaiae
E. Coli L. Monocytogenes |
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Common bacteria in older children, teenagers, adults < 50- -menningitis
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N. Meningitis, S. Pneumoniae, H. Influenzae
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Common bacteria in> 50- menningitis
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- L. Monocytogenes, N. Meningitis, S. Pneumoniae
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What is the most common syndrome affecting the CNS?
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Aseptic meningitis syndrome
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The classic presentation of meningitis?
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fever, headache, neck stiffness, photophobia, nausea, vomiting
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Meningitis Triad
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fever, nuchal rigidity, AMS
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Physical Exam Findings- meningitis
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Kernig's, Brudinski's signs
headache, fever, nuchal rigidity AMS |
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petechial, purpuric, ecchymotic rash w/ meningeal findings?
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Meningococcal infection
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Diagnostic evaluations- meningitis
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CBC w/ diff ( left shift- bacterial), blood cultures, CSF: chemistry, opening pressure, cell count, gram stain and culture
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Imaging for meningitis
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CT- before LP
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CSF results : bacterial meningitis
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: opening pressure 200-300, WBC 100-5000> 80% PMNs, glucose< 40, Protein >100, + culture
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CSF results: viral meningitis
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opening pressure- 90-200, WBC- 10-300 lymphs, Glucose- normal/reduced, Protein- slighlty elvated, neg- culture
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Medical Management - meningitis
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Initial tx as bacterial if cannot be r/o
In older children & adults- cefotaxime or ceftriaxone, vancomycin in adults > 50 years ampilcillin is added to vanco and 3rd gen cephalosporins dexamethasone in children before 3rd gen cephalosporin |
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How long should meningitis infection of L. monocytogenes be treated for?
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21 days
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prompt prophylaxis is warranted for contacts of a meningococcal patient? T or F
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True
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a nuerological deficit that lasting more then 24 hours that is caused by reduced blood flow in an artery supplying part of the brain- leads to infarction
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Stroke
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2 types of strokes
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hemorrhagic
ischemic |
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ischemic strokes counts for % of strokes
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85%
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Most common disorder that leads to stroke
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Athersclerosis
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Athersclerosis can cause stroke in three different ways:
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*mural thrombosis- obstructs artery
*ulceration or rupture of the the plaque- leads to clot *hemorrhage into a plaque obstructs artery |
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Risk factors for Stroke:
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hypertension, smoking, heart disease, hypercholesterolemia, disease associated increased viscosity of the blood, OCPs
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What is the most important risk factor for a stroke?
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HTN
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If stroke symptoms reslove within 1-2 hours patient had a ?
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TIA
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Sings and symptoms of stroke
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drooping of facial muscles- can wrinkle forehead, paresis, visual loss, diplopia, dysarthria, aphasia, decreased level of consiousness
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Stroke of what artery produces: contralateral hemiparesis, contralateral hyperhesia, ipsilateral hemianopsia, gaze preferenace toward lesion, weakness of upper extremities > lower exremities
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MCA
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What artery stroke causes: producing primary reflexes, AMS, imparied judgement, contralateral weakness, contralateral cortical sensory deficits, apraxia, urinary incontinence
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ACA
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what artery stroke causes: homonymous hemianopsia, cortical blindness, visual agnosia, AMS, impaired mental status
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PCA
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Infarct of what artery causes: nystagmus, vertigo, diplopia, visul fields deficits, dysphagia, dysarthria, syncope, ataxia
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Vertebrobasilar artery
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Hallmark of posterior circulation loss?
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ipsilateral cranial nerve deficit and contralateral motor deficits
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Diagnostic evaluations of stroke?
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CBC, ESR- giant cell arteritis, blood gulcose, prothrombin time and partial thrombin time, EKG
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Imaging for stroke
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CT scan- standard initial imaging study, MRI- most sensitive
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What is the gold standard imaging study for a cerebral stroke?
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cerebral angiography
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Emergent management for a Cerebral Stroke?
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Thrombolytic therapy- only safe and effective way for acute managment of stroke: t-pa- start within 3 hours- if hypertensive (185/110) give labetol m(BB) before starting t-PA
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a prolonged seizure that last > 30 min
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Status Epilepticus
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physical exam findings- status epilepticus
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complusive: generalized/focal seizure activity
non-convulsive: confusion, delirium, bizzare behavior, memory loss catatonia changes in respiration, temp, bp |
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Emergency management - status epilepticus?
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ABCs, IV, ECG, Thiamine, D50- unless glucose known, Lorazepam, Diazepam, phenytoin, phenobarb, propofol
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Diagnostic evaluations- status eplilepticus
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antiepileptic drug levels, CBC, CMP, CT, ECG, LP, UA tox
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when are the peak incidences of epilepsy?
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childhood and elderly
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Partial seizure -def
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involve localized region or collection of cells in a specific area that display a bursting behavior
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Generalized seizures
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diffuse clinical and EEg changes that involve many areas of the brain
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do simple partial seizures have altered consciousness?
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no
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When is a partial seizure become complex?
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when consciousness is altered
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Generalized clonic-tonic seizure- physical findings
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patient becomes stiff, clonic, rhythmic jerking of all four extremities, diaphoretic, urinary incontinence, cyanosis
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