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55 Cards in this Set
- Front
- Back
Gonadal Steroid Biosynthesis
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Cholesterol > Progesterone > Testosterone ----> aromatase > estradiol
Cholesterol > Progesterone > Testosterone -----> alpha reductase > DHT |
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The biosynthesis of the gonadal steroid begins with the precursor ________.
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Cholesterol
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Testosterone is acted upon by the enzyme _________ and is converted into __________.
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Aromatase
Estradiol |
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Testosterone acted upon by _________ is converted into __________.
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Alpha Reductase
Dihydrotestosterone (DHT) |
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Is DHT more potent than testosterone?
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Yes
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GnRH receptors are tied to a _______.
(Gq/Gs/Gi/None Metabotropic) |
Gq
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FSH receptors are tied to a ________.
(Gq/Gs/Gi/None Metabotropic) |
Gs
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LH receptors are tied to a ________.
(Gq/Gs/Gi/None Metabotropic) |
Gs
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Cytokine receptors are tied to a ________.
(Gq/Gs/Gi/None Metabotropic) |
None Metabotropic
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GnRH, FSH, and LH receptors are metabotropic. They contain _________ transmembrane segments.
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Seven
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True or False:
Cytokine receptors are not metabotropic receptors. |
True
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Is Estrogen a Gonadal Steroid or an Adrenal Steroid?
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Gonadal Steroid
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is Progesterone a Gonadal Steroid or an Adrenal Steroid?
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Gonadal Steroid
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Is Mineralcorticoid a Gonadal Steroid or an Adrenal Steroid?
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Adrenal Steroid
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Is Androgen a Gonadal Steroid or an Adrenal Steroid?
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Gonadal Steroid
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Is Glucocorticoid a Gonadal Steroid or an Adrenal Steroid?
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Adrenal Steroid
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Estrogen receptors are tied to a _________.
(Gq/Gs/Gi) |
Gq
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Progesterone receptors are tied to a _______.
(Gq/Gs/Gi) |
Gq
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Androgen receptors are tied to a _______.
(Gq/Gs/Gi) |
Gs
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Glucocorticoid receptors are tied to a ______.
(Gq/Gs/Gi) |
Gs
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Mineralocorticoid receptors are tied to a _____.
(Gq/Gs/Gi) |
Gq
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Name all of the Estrogen receptors.
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Estradiol, Estriol, Clomiphene, Estrone, Tamoxifen
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Name all of the Androgen receptors.
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DHT, Flutamide, Testosterone.
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Name all of the Progesterone receptors.
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Mifepristone, Progesterone
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Name all of the Glucocorticoid receptors.
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Mifepristone, Cortisol, Corticosterone
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Name all of the Mineralocortocoid receptors.
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Aldosterone, Spironolactone
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What intracellular steroid hormone receptor does Estradiol belong to?
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Estrogen Receptors
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What intracellular steroid hormone receptor does DHT belong to?
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Androgen Receptors
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What intracellular steroid hormone receptor does Estriol belong to?
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Estrogen Receptors
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What intracellular steroid hormone receptor does Mifepristone belong to?
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Progesterone Receptors
Glucocorticoid Receptors |
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What intracellular steroid hormone receptor does Cortisol belong to?
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Glucocorticoid Receptors
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What intracellular steroid hormone receptor does Aldosterone belong to?
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Mineralocorticoid Receptors
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What intracellular steroid hormone receptor does Clomiphene belong to?
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Estrogen Receptors
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What intracellular steroid hormone receptor does Flutamide belong to?
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Androgen Receptors
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What intracellular steroid hormone receptor does Corticosterone belong to?
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Glucocorticoid Receptors
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What intracellular steroid hormone receptor does Testosterone belong to?
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Androgen Receptors
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What intracellular steroid hormone receptor does Estrone belong to?
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Estrogen Receptors
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What intracellular steroid hormone receptor does Progesterone belong to?
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Progesterone Receptors
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What intracellular steroid hormone receptor does Tamixifen belong to?
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Estrogen Receptors
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What intracellular steroid hormone receptor does Spironolactone belong to?
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MIneralocorticoid Receptors
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Estrogen receptors are _________, they consist of alpha and beta receptors.
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Heterodimeric
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Estrogen receptor antagonists are used for the treatment of _________.
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Breast Cancer
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Anatrozole is an aromatase inhibitor which blocks the enzyme that produces _______.
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Estrogen
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What drug changes the lining of the uterus so that it is incompatible with implantation of a fertilized egg?
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Mifepristone
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Androgen receptors are _________, they consist of an ARA and an ARB receptor.
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Heterodimeric
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Name a ligand that is an alpha-reductase inhibitor.
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Finasteride
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Hormonal regulation of Estrus
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Arcuate N ; PVN ---->GnRH > Posterior Pituitary > Anterior Pituitary ------>FHS/LH > Ovaries
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Prolactin signals to ______.
(Gq/Gs/Gi/JAK/STAT) |
JAK (Janus Kinase)
STAT (Signal Transduction And Transcription Factor) |
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Estrogen Antagonists
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Clomiphene
Tamoxifen |
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Androgen Antagonist
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Flutamide
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Progesterone Antagonist
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Mifepristone
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Glucocortico Antagonist
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Mifepristone
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Mineralocorticoid Antagonist
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Spironolactone
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Minoxidil
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K ATP activator
Used to treat male-pattern baldness |
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Receptors for ACTH are found in the _____.
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Adrenals
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