Drugs Used To Treat Angina Pectoris

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Angina Pectoris types

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Stable Angina

Unstable Angina

Variant Angina

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Angina Pectoris meaning

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Chest discomfort arising from the heart due to lack of oxygen to the heart muscle

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discomfort that are usually predictable and manageable.
relieved with rest, nitroglycerin or both.

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Chronic stable angina

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heart doesn't get enough blood flow and oxygen. It may lead to a heart attack

chest discomfort caused by poor blood flow through the blood vessels (coronary vessels) of the heart muscle (myocardium)

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Unstable angina

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usually at rest and often between midnight and early morning

Prinzmetal or vasospastic angina

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variant angina

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Nitrates actions

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Decreases oxygen demand on heart; dilates arteries and veins; reduces blood volume; decreases preload on heart

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Nitrates adverse affect

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Excessive hypotension, prolonged headache, tolerance (with longer-acting nitrates)

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ED drugs [sildenafil (Viagra)] can potentially lower blood pressure

Drug interaction with?

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Nitrates

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Nitrates are?!

causes headaches because of it

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VASODILATORS - dilates vessel

iE heart and head

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Sublingual is where?

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under the tongue

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placing drugs there is placing them where?

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sublingual
Used in emergency

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Sublingual guidelines

nitrates

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store dark and not warm
replace every 6months
if not relieve within 5min call ambulance nd give every 5min while waiting

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Nitrates Transdermal guidelines

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on dry, hairless, intact skin as on upper arm or chest

remove for 8-12h

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Nitrates intravenous nitroglycerin guidelines

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used in acute areas, CHECK ON VITALS

infusion pump for accuracy, titrate

Can't be mixed with other meds

use special tubes so it won't be absorbed

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DRUG CLASSES

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-Beta-Adrenergic Blocking Agents
-Nitrates

-Calcium Channel Blockers

-ACE Inhibitors

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Beta-Adrenergic Blocking Agents actions

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Block beta-adrenergic receptors in heart

Reduce myocardial oxygen demand

Reduce blood pressure

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Beta-Adrenergic Blocking Agents

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Reduce the number of anginal attacks

Reduce nitroglycerin use

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Beta-Adrenergic Blocking Agents shouldn't be used on people with

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diabetic and asthma

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beta-adrenergic blocking agents can cause what with diabetics

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hypoglycemia

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Beta-Blockers end with?

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OLOL

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Beta-Blockers causes what what to the heart?

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Drop of HR

Drop of force of concentration

drop of rate of A-V conduction

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Beta-Blockers side effects

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Bradycadria

lethargy

GI Disturbance

congestive heart failure (CHF)

drop of BP

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Calcium Channel Blockers actions

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Inhibit flow of calcium ions across cell membrane

Reduce peripheral vascular resistance

Improve coronary blood flow

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Calcium Channel Blockers uses

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Reduce incidence of MI, secondary prevention for patients with known coronary artery disease

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Calcium Chanel Blockers
Very
Nice
Drugs

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Verapamil Ve-Ra-Pa-Mil

Nifedipine Ni-Fed-Ip-ine

Diltiazem Dil-Ti-Az-Em

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Calcium Chanel Blockers actions :

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Drops Contractility,

Drops Conductivity of the heart and

Drops demand for oxygen

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Calcium Chanel Blockers side effects:

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drops BP,

Bradycardia

May precipiate AV block,

Headache,

Abdominal pain (nausea, constipation),

Peripheral edema

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ACE Inhibitors actions

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Promote vasodilation, minimize cellular aggregation, prevent thrombus formation

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ACE Inhibitors uses

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Reduce incidence of MI; secondary prevention for patients with known coronary artery disease (CAD)

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ACE Inhibtiors end in

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"-pril"