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24 Cards in this Set
- Front
- Back
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MOA sulfasalazine in inflammatory bowel disease
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inhibits 5-lipoxygenase (mainly) to decrease production of leukotrienes - anti-inflammatory effect
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sulfasalazine contains which 2 compounds?
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5-ASA and sulfapyridine
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Why is sulfapyridine a component of sulfasalazine?
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enables delivery of 5-ASA to colon
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Sulfasalazine would treat crohn's disease involving which part of the intestine?
duodenum jejunum ileum colon |
colon
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Olsalazine will induce remission, maintain remission or both in a patient with inflammatory bowel disease
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both
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Clinical use of sulfasalazine - mild and/or severe inflammatory bowel disease
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mild
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Side effects of sulfasalazine
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GI problems and hypersensitivity reactions (Fever, Skin rash, Hemolytic anemia, Agranulocytosis, Pancreatitis, Pulmonary complications, Hepatitis)
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prednisone - will it induce remission, maintain remission or both in a patient with inflammatory bowel disease
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induce remission
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Clinical use of prednisone - mild, moderate, and/or severe inflammatory bowel disease
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moderate and severe (can use 5-ASAs for mild disease)
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what is steroid dependent inflammatory bowel disease?
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A patient is on a steroid for their IBD. When they start to be weaned from the steroid, thier symptoms return.
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Will azathioprine induce remission, maintain remission or both in a patient with inflammatory bowel disease
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both
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Will methotrexate induce remission, maintain remission or both in a patient with inflammatory bowel disease
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both
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Will cyclosporine induce remission, maintain remission or both in a patient with inflammatory bowel disease
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induce remission
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Will azathioprine be used to maintain remission in mild and/or severe inflammatory bowel disease
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severe
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Will methotrexate be used to maintain remission in mild and/or severe inflammatory bowel disease
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severe
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Which drug(s) would you use to induce remission in a patient with inflammatory bowel disease who is unresponsive to steroids?
budesonide sulfasalazine 6-mercaptopurine methotrexate infliximab |
6-mercaptopurine
methotrexate infliximab |
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How long does it take for azathioprine to induce remission in a patient with inflammatory bowel disease
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months
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How long does it take for infliximab to induce remission in a patient with inflammatory bowel disease
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couple of weeks
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MOA of infliximab in inflammatory bowel disease
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blocks TNF-alpha's role in inflammation
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Is infliximab used for inducing remission, maintianing remission or both in a patient with inflammatory bowel disease?
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both
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Is infliximab used in mild and/or severe inflammatory bowel disease
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severe
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Are all TNF antagonists effective in treating inflammatory bowel disease
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No
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Where does sulfasalazine work?
in gut lumen or systemically |
gut lumen
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what is the difference between prednisone and budesonide?
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budesonide has high first pass metabolism by the liver
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