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5 Cards in this Set
- Front
- Back
- 3rd side (hint)
Hydroxyurea mechanism
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Inhibits ribonucleotide reductase (down deoxyribunleotides)
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Sickle cell (increase HbF), melanoma, CML (bone marrow suppression)
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6-MP mechanism
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Blocks de novo purine synthesis (down dAMP and dGMP)
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Leukemia, lymphomas (non-CLL or Hodgkins), bone marrow, GI liver tox
Metab by xanthine oxidase (increase tox w/ allopurinol) |
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5-FU mechanism
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Blocks thymidylate synthase (down dTMP)
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Colon cancer, solid tumors, basal cell carcinoma (topical), used w/ MTX
Rescue w/ thymidine |
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Methotrexate
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Blocks DHF reductase (down dTMP)
Folic acid analogue |
Leukemia, lymphoma, sarcoma, abortion, ectopic pregnancy, RA, psoriasis
Myelosupresssion, reversible w/ leucovorin (folinic acid) rescue |
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Trimethoprim mechanism
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Blocks Bacterial DHF reductase (down dTMP)
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UTIs, Enterics (Shigella, salmonella, pneumosystis jirovei pneumonia)
Megaloblastic anemia, leukopenia, granulocytopenia, can rescue w/ folinic acid (leukovorin) |