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55 Cards in this Set
- Front
- Back
Methotrexate |
Anti metabolite - purine and thymidylate |
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Leflunomide |
Inhibit dihydrooroatw dehydrogenase - pyrimidine |
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Sulfasazine |
Reducw IL 2/1 and chemokines |
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Hydroxy chloroquine |
Inhibits tlr9 - inhibits inflammation |
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Infliximab |
Inhibit tnf alpha |
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Tocilizumab |
Inhibition of IL 6 |
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Rituximab |
Inhibits b cells, binds to cd20 |
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Abatacept |
Inhibits cd80/86 on APC |
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Irinotecan |
Sn-38 prodrug |
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Doxorubicin |
Topii intercalators breaks more dsdna |
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5fu |
Anti metabolite fdump fdutp futp DNA and RNA damage |
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Carpectibane |
Metabolised to 5fu |
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Gemcitabine |
Analogue of cytidine |
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Pacli/docetaxel |
Prevents microtubule disassembly |
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Gefinitib |
Egfr tyrosine kinase inhibitor lung cancer need mutation |
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Cetuximab |
Egfr her1/erbb1 |
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Bevacizumab |
Vegf |
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Vemurafenib |
Inhibits atp site of active braf kinase |
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Ipilimumab |
Clta4 inhib/blocks cd28 |
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Nivolumab/pembrolizumab |
Pd1 inhibitor |
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Tamoxifen |
Estrogen antagonist |
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Trastuzumab |
Her2 inhibition of dimerisation |
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Abirateron |
Cyp17 inhib adt |
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Finasteride |
5alpha reductase inhib adt |
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Bicalutamide |
Androgen receptor antagonist adt |
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Afibercept |
Vegf rcpetor, decoy crpc |
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Cabozantinib |
Blocks met pathway crpc kin inhib |
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Dasatinib |
SRC tyrosine kinase inhibitor |
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Zoledronic acid |
Decrease bone metastasis |
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Erlontinib |
Anti egfr tki mutation needed |
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Aspirin |
Inhibits co mi |
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Clopidogrel |
Glycoprotein inhib iib/a - ADP p2y12 antagonist - anti coagulation mi |
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Tirofiban/eptifibatide |
Glycoprotein iib/a receptor antagonist - prevent fibrinogen bind - anti coagulation mi |
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Epoprostenol |
Synthetic pg12 |
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Streptokinase, alteplase |
Lead to activation of plasminogen to form plasmin, plasmin digests the fibrin of clot MI |
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Lisinopril |
Achei - reduce BP and cardiac hypertrophy, get cough cough, HF |
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Metoprolol |
B-blocker, slow HR, increase myocardial relaxation, greater filling in diastole, HF |
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Thiazide loop and k+ HF? |
Reduce fluid and achieve euvolaemia, combine with acheis and b blocker |
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Digoxin |
Inotropic agent, decreases na+/CA++ exchange HF, increases cardiac contractility, inhibits na k ATPase |
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Frusemide/bumetanide |
Inhibit na/k/2cl transporter decrease water reabsorption |
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Hydrochlorothiazide, inapamide |
Inhibit na cl co transporter |
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Spironolactone |
Blocks aldosterone |
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Amiloride |
Blocks na channels |
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Pril drugs - enalapril, perindopril, ramipril |
Ace inhibitors |
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Sartans- iosartan, valsartan |
Angiotensin II receptor antagonists HT |
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Dihydropyridines- amlopidine, nifedipine |
Hypertension and angina - amlopidine indirect allosteric blocker, ccbs |
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Verapamil/diltiazem - non dihydropyridines |
Ccbs Vera is a phenylalkylamine acts on heart, HT angina and cardiac arrhythmias |
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Statins - atorva, prava |
Hmg coa reductase, prevents coversion to cholesterol and increases LDL receptors on hepatocytes in liver |
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Cholestyramine, colestipol and colesevelam |
Bile salts sequestrants, inhibit the reabsorption of bile acids from the intestine |
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Ezetimibe |
Inhibits bpc1l1 to inhibit intestinal absorption of dietary and biliary cholesterol |
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Nicotinic acid |
Inhibits hepatic VLDL secretion |
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Fenofibrate/gemfibrozil |
Reduce VLDL and TG levels by stimulating peroxisome proliferator activated receptor type alpha ppar |
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Dalcetrib/anacetrapib |
Cholesterol lowering - cholesterylester transfer protein inhibitors |
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PCSK9 inhibitor - alirocumab |
Promotes degradation of ldlr by preventing recycling of ldlr to cell membrane |
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Valsartan |
AT II receptor antagonist, alternative to acheis HF |