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20 Cards in this Set
- Front
- Back
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Name 12 immunosuppresants?
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azathioprine
bailiximab chlorambucil cyclophosphamide cyclosporine daclizumab methotrexate muromonab-CD3 mycophenolate sirolimus tacrolimus thalidomide |
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Azathioprine, basiliximab, cyclosporine, daclizumab, mycophenolate, sirolimus, and tacrolimus are used with _____ in the prevention of transplantation rejection reactions.
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corticosteroids
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Which agent is used to manage rejection reactions not controlled by other agents?
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Muromonab-CD3
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Which 3 agents are used in the management of selected autoimmune diseases (nephrotic syndrome of childhood and severe rheumatoid arthritis).
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azathioprine
cyclophosphamide methotrexate |
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Immunosuppressants inhibit ____-_____ immune responses by different mechanisms.
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cell-mediated
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In addition to azathioprine and cyclosporine, which are used primarily for their immunomodulating properties, cyclophosphamide and methotrexate are used to suppress the ______ _______ in certain disease states (nephrotic syndrome of childhood and severe rheumatoid arthritis).
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immune responses
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Muromonab-CD3 is a recombinant _______ antibody that alters T-cell function.
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immunoglobulin
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Basiliximab and daclizumab are ______ antibodies.
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monoclonal
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Contraindications?
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hypersensitivity to drug or vehicle
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Precautions?
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use cautiously in patients with infections...
safety in pregnancy and lactation not established |
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Allopurinol inhibits the _____ of azathioprine.
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metabolism
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Drugs that alter liver-metabolizing processes may change the effect of ______.
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cyclosporine
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The risk to toxicity of ______ may be increased by other nephrotoxic drugs, large doses of aspirin, or NSAIDs.
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methotrexate
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________ has additive immunosuppressive properties; concurrent immunosuppressive doses should be decreased or eliminated.
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Muromonab-CD3
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What should the nurse assess for when patient is taking immunosuppressants?
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infection (VS, sputum, urine, stool, WBCs); notify hcp immediately if symptoms occur...
organ rejection... CBC differential |
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List 2 potential nursing diagnoses?
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Infection, risk for....
Knowledge, deficient, related to disease processes and medication regimen |
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IMPLEMENTATION:
Protect _______ patients from staff and visitors who may carry infection. Maintain protective isolation as indicated. |
transplant
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Reinforce the need for lifelong therapy to prevent 1______ _____. Review symptoms of 2_______ for transplanted organ and stress need to notify hcp immediately if they occur.
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1 transplant rejection
2 rejection |
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Advise patient to avoid contact with _____ persons and those who have recently taken oral ____ virus vaccine. Patients should not receive vaccinations without first consulting with hcp. Emphasize the importance of follow-up exams and lab tests.
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contagious
polio |
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EVALUATION:
Effectiveness of therapy can be demonstrated by? Prevention or reversal of rejection of ___ ____ or decrease in symptoms of autoimmune disorders. |
organ transplants
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