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14 Cards in this Set

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Hypercholesterolemia
Causes:
Primary: genetic predisposition

Secondary: high caloric intake, obesity, hypothyroidism, DM2, hepatic disease, HIV drugs, beta blockers, & hypercortisolism
Manifestations:
Increase in smooth muscles
Influx of macrophages
Atherosclerosis
Atherosclerosis
Causes:
Hypercholesteremia
Increasing age
Family history
Smoking
Obesity
Manifestations:
Fatty Streaks (foam cells)
Atheromatous Plaques (calcification)
Complicated Lesions (scar)

Angina in any tissue or organ
Small Vessel Vasculitis
Causes:
Type 3 immune complex reaction

Drugs, infections, autoimmune diseases
Manifestations:
Fever
Purpura
Myalgia
Medium Vessel Vasculitis
Causes:
Infections, drugs, neoplasias
Manifestations:
Myalgia, low grade fever, arthralgia, & integument cyanosis
Large Vessel Vasculitis
Causes:
Granulomatous (chronic inflammtion)
Manifestations:
Headache, swelling and redness, blurred vision, facial pain
Acute Arteriole Occlusion
Causes:
Embolus: free moving particle

Thrombus: particle attached to surface
Manifestations:
Pallor, pain, polar (cold), pulseless, paresthesia (pins and needles), paralysis, pistol shot onset
Atherosclerotic Occlusive Disease
Causes:
Smoking
Diabetes
Manifestations:
Intermittent claudication
Pain associated with walking
Atrophic changes(light & shiny skin)
Loss of hair follicles (alopecia)
Ischemia
Ulcerations
Gangrene
Thromboangiitis Obliterans (Buerger Disease)
Cause:
Tobacco Use (smoking & chewing)
Manifestations:
Intermittent claudication
Pain associated with walking
Cold sensitivity
Atrophic changes
Raynaud's Disease
Causes:

Disease: set off by cold or strong emotion (associated with women)

Phenomenon: previous damage
Manifestations:
Pallor, cyanosis, numbness, tingling, hyperemia, paresthesia, atrophic changes, ulcerations
Aneurysm
Causes:
Congenital defects
Trauma
Infections
Atherosclerosis
Hypertension
Manifestations:
Pain
Hoarseness
Dyspnea
Difficulty swallowing
Aortic Dissection
Causes:
Hypertension
Medial layer degeneration of vessel
Congenital defects to aorta
Manifestations:
Excruciating pain
Hypertension (early)
Unobtainable pulse (later)
Paralysis of lower extremities
Vericose Veins
Causes:
Increased hydrostatic pressure(standing)
Increased intra-abdominal pressure
Obesity

Primary: small superficial veins

Secondary: great saphenous vein (deep)
Manifestations:
Stasis dermatitis
Raised vein appearance
Aching, heavy legs
Chronic Venous Insufficiency
Causes:
Deep vein thrombosis
Valve failure
Manifestations:
Edema
Skin atrophy
Necrosis of fat deposits
Brown pigmentation (hemosiderin)
Stasis dermatitis
Venous Thrombosis
Causes:
Hypercoagulability
Inherited risk factors
Contraceptive & hormone replacement
Cancer
Infection
Vessel injury
Manifestations:
Asymptomatic
Pain
Swelling
Deep muscle tenderness
Fever
General malaise
Increased WBC count
Increased erythrocyte sedimentation